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Quantitative multidimensional optical spectroscopy: revealing dynamics and structure in complex condensed matter systems. Understanding how quantum mechanics affects photosynthesis and how it can cause interactions between distant nanostructures are intriguing problems that may be of great significance for future smart technologies. This project will gain unprecedented insight into these processes using a novel technique to identify and resolve the mechanisms responsible.
Maximizing solid state Nuclear Magnetic Resonance (NMR) with maximum entropy. Nuclear magnetic resonance is an essential technology for the characterisation of important industrial and biomedical molecules, molecular chains and complexes. This project aims to considerably expand the fundamental capability of experimental techniques for the study of materials in the solid state, in particular for a new class of biological nanoparticle. These advances will have important global implications for re ....Maximizing solid state Nuclear Magnetic Resonance (NMR) with maximum entropy. Nuclear magnetic resonance is an essential technology for the characterisation of important industrial and biomedical molecules, molecular chains and complexes. This project aims to considerably expand the fundamental capability of experimental techniques for the study of materials in the solid state, in particular for a new class of biological nanoparticle. These advances will have important global implications for research into life-saving therapeutic strategies aimed at many pharmaceutical targets embedded in cell membranes, protein misfolding disorders such as Alzheimer's disease and Huntington's disease, as well as development of the next generation of "green" plastics and other advanced polymers.Read moreRead less
Enhancing our understanding of metallochemistry in neurobiology with modern electron paramagnetic resonance (EPR) spectroscopy. Many neurological diseases involve protein accumulation that appears causally linked to abnormal levels of metal ions in the brain. This project will use a special technique called electron paramagnetic resonance to uncover how these metals interact with specific proteins at the molecular level and how drug treatments can modify these interactions.
Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collecti ....Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collection of structure restraints by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and mass spectrometry, which are needed to generate accurate models of proteins and their complexes with other molecules. Major beneficial outcome will include an increase in the number of protein targets amenable to rational drug design and improved methods for generating new drug leads.Read moreRead less
Photonic circuitry from the noble metals: nanocrystal coupling. Linear arrays of crystalline nanoparticles are able to act in a manner analogous to an optical fibre, but with much smaller dimensions. This project will investigate the underlying principles of waveguiding within the arrays and aims to build and test sections of such optical fibres, thereby assessing their use in optical circuits.