Supramolecular assembly in photovoltaic electrode design: Studies of ordered porphyrin/acceptor complexes on polythiophene electrodes. This research outlines an improved way to develop dye-sensitised photovoltaic solar cells for the conversion of sunlight into electricity, by increasing the molecular order of the cell components using host, guest interrelationships. As such, it addresses a problem of international concern 'How to reduce greenhouse gas emissions and stop global warming?' since s ....Supramolecular assembly in photovoltaic electrode design: Studies of ordered porphyrin/acceptor complexes on polythiophene electrodes. This research outlines an improved way to develop dye-sensitised photovoltaic solar cells for the conversion of sunlight into electricity, by increasing the molecular order of the cell components using host, guest interrelationships. As such, it addresses a problem of international concern 'How to reduce greenhouse gas emissions and stop global warming?' since solar cells do not produce carbon dioxide. To achieve our goals we draw on the skills of a team of experts from Australia (synthetic organic chemists), New Zealand (polymer and surface chemists) and Italy (photochemist and photophysicist). Such research is very appropriate for regional Australia, especially Central Queensland.Read moreRead less
Development of an Adjustable Porphyrin-based Molecular Platform for Nanotechnology Applications. Nanotechnology, the art of molecular control, is often heralded as the next industrial revolution. For this to be realised, the construction of useful devices will require precise control at the molecular level. Our control is realised through a process called self-assembly which means that the once the components of the device are correctly designed, the device will simply be able to put itself tog ....Development of an Adjustable Porphyrin-based Molecular Platform for Nanotechnology Applications. Nanotechnology, the art of molecular control, is often heralded as the next industrial revolution. For this to be realised, the construction of useful devices will require precise control at the molecular level. Our control is realised through a process called self-assembly which means that the once the components of the device are correctly designed, the device will simply be able to put itself together. This research will use nature's light harvesting elements, namely porphyrins, and our ability to precisely control their position with respect to each other to build new, more efficient solar cells.Read moreRead less
An Integrated Approach Towards Development of Highly Specific Chemotherapeutics. Many diseases are caused or can be treated by modifying the activities of particular enzymes. Molecules that affect enzymatic activities have potential as therapeutic agents. A successful approach to the discovery of new drug molecules is to design them based on very detailed knowledge of how the target enzyme works. In this project, a highly motivated team of scientists will use state of the art instruments and the ....An Integrated Approach Towards Development of Highly Specific Chemotherapeutics. Many diseases are caused or can be treated by modifying the activities of particular enzymes. Molecules that affect enzymatic activities have potential as therapeutic agents. A successful approach to the discovery of new drug molecules is to design them based on very detailed knowledge of how the target enzyme works. In this project, a highly motivated team of scientists will use state of the art instruments and their combined creativity to understand the intimate details of how one large group of enzymes work. The enzymes selected are the bimetallic hydrolases, many of which are associated with disorders including osteoporosis, mental illnesses, cystic fibrosis and various types of cancer.Read moreRead less
Development of an efficient oxygen-thiosulfate process for the recovery of gold from ores. Gold is currently recovered from the ore by a cyanide leaching process. This high risk procedure is used because there is currently no safe alternative. The research we propose to undertake will investigate a novel thiosulfate-oxygen process to dissolve gold. Successful completion of the project will identify the mechanism of the process and could lead to the replacement of the highly toxic cyanide with th ....Development of an efficient oxygen-thiosulfate process for the recovery of gold from ores. Gold is currently recovered from the ore by a cyanide leaching process. This high risk procedure is used because there is currently no safe alternative. The research we propose to undertake will investigate a novel thiosulfate-oxygen process to dissolve gold. Successful completion of the project will identify the mechanism of the process and could lead to the replacement of the highly toxic cyanide with the non toxic thiosulfate. Thus the proposed project has the potential to substantially alter the gold recovery process, particularly in an era where environmental and public concerns exist over the use of cyanide.Read moreRead less
Skin penetration of nanoparticles promoted by particle design, formulation and application method. This project seeks to better define the determinants of nanoparticle skin penetration and subsequent disposition in the body. The data would be used to guide minimal skin penetration of 'undesirable' nanoparticles and the properties required of 'safe' nanoparticles to enable effective human skin delivery in cosmetic and dermatological products.
The photons take charge: Elucidating the structure and stability of distonic radical anions by mass spectrometry and photoelectron spectroscopy. Recent work has discovered that certain radical anions have electronic configurations that defy chemical convention and exhibit exceptional radical stability. Exploitation of this breakthrough first requires experimental elucidation of the intrinsic electronic structure of these compounds and how it relates to their remarkable properties. This project w ....The photons take charge: Elucidating the structure and stability of distonic radical anions by mass spectrometry and photoelectron spectroscopy. Recent work has discovered that certain radical anions have electronic configurations that defy chemical convention and exhibit exceptional radical stability. Exploitation of this breakthrough first requires experimental elucidation of the intrinsic electronic structure of these compounds and how it relates to their remarkable properties. This project will probe the fundamental structure and energetics of radical anions by modifying instrumentation to enable multi-step gas-phase ion synthesis to be efficiently coupled with anion photoelectron spectroscopy. These investigations are essential to revealing the scope of this phenomenon in free radical chemistry and biology and could inform future development of new catalysts for polymerisation.Read moreRead less
Advancing the Science of Giant Planet Atmospheric Entry. This project aims to improve models used to design the heat shields which protect probes entering the atmospheres of the giant planets - four gaseous planets out beyond Mars. Further giant planet exploration is a key planetary science goal of the coming decade. However, the environment which an entry probe would experience features many unknowns and large uncertainties, making a mission a risky undertaking. Using unique experimental capabi ....Advancing the Science of Giant Planet Atmospheric Entry. This project aims to improve models used to design the heat shields which protect probes entering the atmospheres of the giant planets - four gaseous planets out beyond Mars. Further giant planet exploration is a key planetary science goal of the coming decade. However, the environment which an entry probe would experience features many unknowns and large uncertainties, making a mission a risky undertaking. Using unique experimental capabilities and state-of-the-art modelling, the expected project outcome is experimentally validated giant planet entry flow and surface chemistry models. This will allow more efficient heat shields to be designed while also increasing the chance of mission success, furthering our understanding of the universe.Read moreRead less
Flexible molecular crystals: single crystals that bend, stretch and twist. This project aims to thoroughly quantify the elastic flexibility of a suite of metal-organic molecular crystals. Since antiquity, crystalline materials have been thought to be brittle and inflexible. Crystals can, in fact, display appreciable, even remarkable, elasticity. Some crystals can bend, stretch and twist. The influence that the molecules, and their arrangements in crystals, have on the extent of elasticity will b ....Flexible molecular crystals: single crystals that bend, stretch and twist. This project aims to thoroughly quantify the elastic flexibility of a suite of metal-organic molecular crystals. Since antiquity, crystalline materials have been thought to be brittle and inflexible. Crystals can, in fact, display appreciable, even remarkable, elasticity. Some crystals can bend, stretch and twist. The influence that the molecules, and their arrangements in crystals, have on the extent of elasticity will be determined along with molecular-scale mechanisms for contortion. This information will be used to design new crystals with predictable and tunable elasticity for potential applications previously considered impossible for crystalline materials.Read moreRead less
Methods for Protein Structure Analysis by Electron Paramagnetic Resonance. This highly interdisciplinary project aims to establish new tools to analyse the structure and motions of proteins that are otherwise difficult to study. A combination of advanced biochemistry, modern magnetic spectroscopy methods, and high-performance computing techniques will be applied to study proteins at physiological concentrations and in complex environments. New techniques will be developed and tested on proteins ....Methods for Protein Structure Analysis by Electron Paramagnetic Resonance. This highly interdisciplinary project aims to establish new tools to analyse the structure and motions of proteins that are otherwise difficult to study. A combination of advanced biochemistry, modern magnetic spectroscopy methods, and high-performance computing techniques will be applied to study proteins at physiological concentrations and in complex environments. New techniques will be developed and tested on proteins of high biochemical or biomedical importance, and the approach will be applied to established drug targets.Read moreRead less
New laser and mass spectrometry-based tools for comprehensive structural elucidation of lipids and their biomolecular interactions. Lipid-related disorders such as obesity, diabetes and heart disease are reaching epidemic proportions. We propose the development of specialised instrumentation to identify and quantify lipids (fats) in tissue and culture samples thus providing Australian scientists with unique capabilities to investigate the mechanisms of disease.