Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989127
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of ....A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of option to an existing spectrometer that will broaden its user-base from specialised applications in physics to more general applications in physics, chemistry, materials-science and biology. This additional option provides a totally new way for Australian scientists to study atomic and molecular motions. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100076
Funder
Australian Research Council
Funding Amount
$155,000.00
Summary
The first Australian high pressure Synchrotron facility for geoscience research. In high-pressure mineral physics and chemistry, mineral properties, stress-strain relationships and processes like partial melting are applied to geophysical research about the deep Earth. This project will provide a large volume, high pressure capability at the Australian Synchrotron which will allow these mineral properties to be measured under conditions which simulate the deep earth.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989747
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Ultrafast Dynamics Measurement Facility for the Physical, Biochemical, and Materials Sciences. The term "ultrafast revolution" describes the transformations in science due to ultrafast laser technology. Today, ultrafast lasers are used in surgery, nanomaterial fabrication, biomedical imaging, spectroscopic investigations, and new applications are still emerging. This facility will draw together leading chemists, physicists, and engineers to investigate key ultrafast processes and phenomena in th ....Ultrafast Dynamics Measurement Facility for the Physical, Biochemical, and Materials Sciences. The term "ultrafast revolution" describes the transformations in science due to ultrafast laser technology. Today, ultrafast lasers are used in surgery, nanomaterial fabrication, biomedical imaging, spectroscopic investigations, and new applications are still emerging. This facility will draw together leading chemists, physicists, and engineers to investigate key ultrafast processes and phenomena in the physical, biochemical and material sciences. This is of strategic importance to keep Australia at the global forefront for scientific endeavours, supporting new research and commercial opportunities. This facility will also produce highly trained graduates, who will find employment in industry throughout Australia and globally.Read moreRead less
Three-dimensional structure determination of biomolecular assemblies from sparse data of different length scales. New computer algorithms will be combined with sparse experimental structure restraints, obtained with novel protein chemistry technologies, to generate accurate three-dimensional (3D) models of proteins and protein assemblies in solution and in the solid state. The new strategies will greatly increase the number of protein targets amenable to rational drug design.
Tags and algorithms for studies of protein structures and interactions. This project aims to develop a new set of tools to structurally characterise protein-protein and protein-ligand interactions that are difficult or impossible to analyse by other means, facilitate tracking of proteins in biological material and identify interaction partners. The project seeks to focus on the synthesis of new unnatural amino acids and tags for site-specific protein labelling, and a range of techniques for 3D s ....Tags and algorithms for studies of protein structures and interactions. This project aims to develop a new set of tools to structurally characterise protein-protein and protein-ligand interactions that are difficult or impossible to analyse by other means, facilitate tracking of proteins in biological material and identify interaction partners. The project seeks to focus on the synthesis of new unnatural amino acids and tags for site-specific protein labelling, and a range of techniques for 3D structure analysis in solution, in particular NMR spectroscopy. New algorithms are expected to be developed for optimizing NMR spectroscopy and structure calculations from sparse data. The integrated set of tools is expected to deliver better and faster structure analysis and target characterisation to accelerate early stages of drug discovery.Read moreRead less
Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collecti ....Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collection of structure restraints by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and mass spectrometry, which are needed to generate accurate models of proteins and their complexes with other molecules. Major beneficial outcome will include an increase in the number of protein targets amenable to rational drug design and improved methods for generating new drug leads.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100236
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Facilities for spectroscopy and diffraction at high pressures. The provision of infrastructure for the study of novel materials under high pressures will enhance Australia's capability in creating new materials and in creating new devices that meet needs in communication, environment and medicine applications. The new facility will enable researchers to understand the response of structures to extreme pressures and will exploit the unique capabilities of the synchrotron light.
Brighter than a synchrotron mid-infrared sources for spectroscopy & sensing. This project intends to develop mid-infrared spectroscopy as a powerful diagnostic tool. Mid-infrared spectroscopy allows a light beam to determine the chemical composition of objects or gaseous samples. It has wide applicability — in fields such as medicine, agriculture, the environment, national security and industrial process control — but its use has been hampered by the lack of bright, low-cost sources and integrat ....Brighter than a synchrotron mid-infrared sources for spectroscopy & sensing. This project intends to develop mid-infrared spectroscopy as a powerful diagnostic tool. Mid-infrared spectroscopy allows a light beam to determine the chemical composition of objects or gaseous samples. It has wide applicability — in fields such as medicine, agriculture, the environment, national security and industrial process control — but its use has been hampered by the lack of bright, low-cost sources and integrated devices. This project aims to implement new Australian-made sources that exceed the brightness of even synchrotrons at modest prices. It also aims to demonstrate a single chip integrated version of such a source as the first step towards deployment of mid-infrared technology.Read moreRead less
Selectively targeting cancer and infectious disease with fragment-based drug discovery. Finding better compounds as starting points is one of the major challenges for drug discovery research. Fragments are small, weak binding molecules that can be upsized into drug leads with better properties when compared to starting with larger molecules. This project addresses two weaknesses of current fragment based drug discovery (FBDD) methods: first, the limitations associated with screening fragments; a ....Selectively targeting cancer and infectious disease with fragment-based drug discovery. Finding better compounds as starting points is one of the major challenges for drug discovery research. Fragments are small, weak binding molecules that can be upsized into drug leads with better properties when compared to starting with larger molecules. This project addresses two weaknesses of current fragment based drug discovery (FBDD) methods: first, the limitations associated with screening fragments; and second, the quality of commercial fragment libraries. This project anticipates that the findings will establish a commanding role for both mass spectrometry and three-dimensional fragments in advancing FBDD approaches. It also expects to identify fragments with favourable development prospects towards the next generation of therapeutics.Read moreRead less