The Effect Of Genetic Polymorphisms On The Development Of Systemic Lupus Erythematosus
Funder
National Health and Medical Research Council
Funding Amount
$50,741.00
Summary
Systemic lupus erythematosus is a debilitating disease that predominantly affects women of child-bearing age and may involve any organ. Genetics is one of the most well-recognised risk factors, and yet how genetics can cause lupus is unclear. This study involves examining the entire genetic sequence of individual patients to identify the mutations that cause the immune system to be dysregulated leading to disease.
Determinants Of Outcomes In SLE: Impact Of Models Of Care, Socioeconomic Factors And Biologic Variables In A Multiethnic Australian Population
Funder
National Health and Medical Research Council
Funding Amount
$134,124.00
Summary
Lupus is a chronic disease where the immune cells attack multiple systems in the body, which can lead to severe organ damage and even death. It is known that genes, socioeconomics and models of care all individually influence the outcomes in lupus. The exact contribution of each one is poorly understood, because they are studied in isolation. This project will take an integrated approach to investigating the factors that influence outcomes in lupus, looking for potentially addressable effects.