Virtual testing of orthopaedic devices as part of the design and development process: strategies to account for patient and surgical variability. Novel computational tools will be developed through this project to help account for patient and surgical variability in the design of orthopaedic implants, such as hip and knee replacements and spinal products. These tools will reduce the design time, give greater insight in implant performance and ultimately lead to safer implants with improved longe ....Virtual testing of orthopaedic devices as part of the design and development process: strategies to account for patient and surgical variability. Novel computational tools will be developed through this project to help account for patient and surgical variability in the design of orthopaedic implants, such as hip and knee replacements and spinal products. These tools will reduce the design time, give greater insight in implant performance and ultimately lead to safer implants with improved longevity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100592
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Fabrication strategies for nanophotonic devices. The project will develop novel strategies to engineer nanophotonic entities to control and guide light at the nanoscale. These nanostructures will open up new avenues for integrated multifunctional devices spanning sensing, light emission and quantum communications, positioning Australia at the frontier of nanoscience and quantum technologies.
Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100003
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
3D Nanofabrication and Nanocharacterisation facility. This project aims to establish a revolutionary nanoscale fabrication and characterisation facility in Australia. The facility is an angle-based nanoscale etching system with integrated chemical analysis capabilities and will be the first instrument of its kind in Australia. The facility will enable unprecedented fabrication and characterisation of 3D nanostructures and new device geometries from semiconductors, oxides and metals that underpin ....3D Nanofabrication and Nanocharacterisation facility. This project aims to establish a revolutionary nanoscale fabrication and characterisation facility in Australia. The facility is an angle-based nanoscale etching system with integrated chemical analysis capabilities and will be the first instrument of its kind in Australia. The facility will enable unprecedented fabrication and characterisation of 3D nanostructures and new device geometries from semiconductors, oxides and metals that underpin modern nanoelectronics for innovative energy, nano-optical and quantum device applications. This unique equipment will facilitate breakthrough discoveries in nanomaterials, and foster collaborations amongst Australian researchers to accelerate industry in advanced nanodevice technologies.Read moreRead less
Evaluating the impact of obesity on knee load over time in those who have undergone optimal surgical re-alignment after total knee replacement . This project investigates the impact of obesity on alignment and knee load over time in those who have undergone total knee replacement. This information is critical for understanding whether obesity results in increasing knee load after surgery which can lead to more rapid wearing of the knee surfaces and an earlier need for revision surgery.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100172
Funder
Australian Research Council
Funding Amount
$270,000.00
Summary
Inductively-coupled plasma etching facility. Inductively-coupled plasma etching facility: The aim of this project is to bring together an inductively-coupled plasma etcher with a high resolution tool for optical lithography to create a facility capable of producing nano-structures in silicon surfaces. Such structures are the basis of high performance photonic, nano-electronic, and MicroElectroMechanical (MEM) devices. The lithography tool is a step-and-repeat system capable of exceptionally high ....Inductively-coupled plasma etching facility. Inductively-coupled plasma etching facility: The aim of this project is to bring together an inductively-coupled plasma etcher with a high resolution tool for optical lithography to create a facility capable of producing nano-structures in silicon surfaces. Such structures are the basis of high performance photonic, nano-electronic, and MicroElectroMechanical (MEM) devices. The lithography tool is a step-and-repeat system capable of exceptionally high rates of throughput so this etcher will be a crucial enabling tool for efficient fabrication of nano-devices for research into quantum computing, high bandwidth, quantum-secure optical communications, renewable energy, and for applications in medicine. The etcher will be available for national access.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989384
Funder
Australian Research Council
Funding Amount
$233,000.00
Summary
High-speed, three-dimensional, x-ray fluoroscopy for accurate measurement of human joint motion. This proposal addresses one of the most difficult and long-standing problems in the field of biomechanics: How can human joint motion be measured accurately and non-invasively during common activities such as walking, stair ambulation and running? Low-dose, high-speed, three-dimensional, x-ray fluoroscopy provides an excellent solution to this problem and, in so doing, can play a pivotal role in heal ....High-speed, three-dimensional, x-ray fluoroscopy for accurate measurement of human joint motion. This proposal addresses one of the most difficult and long-standing problems in the field of biomechanics: How can human joint motion be measured accurately and non-invasively during common activities such as walking, stair ambulation and running? Low-dose, high-speed, three-dimensional, x-ray fluoroscopy provides an excellent solution to this problem and, in so doing, can play a pivotal role in healthcare, through clinical gait analysis and gait rehabilitation (diagnosis, prevention and treatment of movement disorders); in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of physics-based animations for the video/digital games industry.Read moreRead less
Scaffolds for bone tissue regeneration and use in orthopaedic applications. Damaged joints do not repair spontaneously, often leading to arthritis. Bone defects resulting from congenital defects or disease processes are challenging to regenerate and represent a major financial burden to our health system. Bone graft treatments are widely used but have considerable drawbacks. This created a need for scaffolds to provide temporary support for new bone. However they lack the combined physical/biolo ....Scaffolds for bone tissue regeneration and use in orthopaedic applications. Damaged joints do not repair spontaneously, often leading to arthritis. Bone defects resulting from congenital defects or disease processes are challenging to regenerate and represent a major financial burden to our health system. Bone graft treatments are widely used but have considerable drawbacks. This created a need for scaffolds to provide temporary support for new bone. However they lack the combined physical/biological properties necessary for bone repair. We developed new scaffolds with improved mechanical/biological properties to mimic bone which will lead to new treatments for bone damage.Read moreRead less
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.