Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Racial Classifications in Transnational Context: Aborigines and Islanders in Australia, Native Americans, African Americans and Afro-Brazilians. This ongoing project seeks to develop a new and more powerful scholarly paradigm for understanding race through a comparative historical study designed to identify features which are common to concepts of race as they have emerged and shifted in the different societies studied, and to distinguish these from features which are specific to particular soc ....Racial Classifications in Transnational Context: Aborigines and Islanders in Australia, Native Americans, African Americans and Afro-Brazilians. This ongoing project seeks to develop a new and more powerful scholarly paradigm for understanding race through a comparative historical study designed to identify features which are common to concepts of race as they have emerged and shifted in the different societies studied, and to distinguish these from features which are specific to particular societies and/or eras. In addition to developing and demonstrating the approach, the project will reanalyse the racialisation of the four colonised groups, each of which have figured centrally in studies of race. One monograph and at least three major journal articles will result.Read moreRead less
Xenologies: Discourses on aliens, foreigners and other races in transnational historical contexts. This project will identify and describe some of the ways in which Western societies have classified and characterised other societies. It will retrace the historical contexts under which such classifications have emerged and developed. A major example is the concept of race, which dates from the late-eighteenth century and developed in close association with the historical expansion of European ....Xenologies: Discourses on aliens, foreigners and other races in transnational historical contexts. This project will identify and describe some of the ways in which Western societies have classified and characterised other societies. It will retrace the historical contexts under which such classifications have emerged and developed. A major example is the concept of race, which dates from the late-eighteenth century and developed in close association with the historical expansion of European colonialism. The concept of race will be situated in the context of other Western discourses on aliens, foreigners, strangers and the like, a comparative procedure that will enhance scholarly understandings of the phenomena of race, racism and xenophobia.Read moreRead less
Mary Astell (1666-1731): An Historical-Intellectual Role Model for Women in Philosophy. Mary Astell was an early modern English philosopher of exceptional eloquence and skill. This project will produce the first overview of her philosophical thought, the first authoritative critical edition of her magnum opus, and the first assessment of her philosophical relevance today. These outputs have the potential to encourage women's participation in philosophy and in intellectual life more generally, ou ....Mary Astell (1666-1731): An Historical-Intellectual Role Model for Women in Philosophy. Mary Astell was an early modern English philosopher of exceptional eloquence and skill. This project will produce the first overview of her philosophical thought, the first authoritative critical edition of her magnum opus, and the first assessment of her philosophical relevance today. These outputs have the potential to encourage women's participation in philosophy and in intellectual life more generally, outcomes that would be of tremendous benefit to Australia's social and economic fabric. The project will also enhance Australia's already outstanding scholarly reputation for early modern studies and the history of women's ideas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668017
Funder
Australian Research Council
Funding Amount
$1,047,000.00
Summary
Membrane Protein Structure and Interaction Facility. While it is estimated that a third of the human genome encodes for membrane proteins, the structures of only relatively few membrane proteins are currently known. It will be some time before membrane protein structure determination becomes routine, yet over 50% of the drugs on the market today rely on the activity of membrane proteins for their efficacy. This application seeks to establish a Membrane Protein Structure and Interaction Facility ....Membrane Protein Structure and Interaction Facility. While it is estimated that a third of the human genome encodes for membrane proteins, the structures of only relatively few membrane proteins are currently known. It will be some time before membrane protein structure determination becomes routine, yet over 50% of the drugs on the market today rely on the activity of membrane proteins for their efficacy. This application seeks to establish a Membrane Protein Structure and Interaction Facility for the development and application of novel techniques and approaches to study the structure and interactions of membrane proteins. Research progress will be greatly enhanced by the establishment of this dedicated facility with cutting-edge technologies for the study of membrane proteins.Read moreRead less
The Political Thought of European Women: 1400-1800. Women's political theory has so far received scant attention in the
history of political thought. Our research aims to address this problem by providing an introduction to the major political texts written by women during the period of 1400-1800. It will result in the first book-length analysis of the political theories of early modern European women and their influence on European political practice. It will highlight the work of many unjustl ....The Political Thought of European Women: 1400-1800. Women's political theory has so far received scant attention in the
history of political thought. Our research aims to address this problem by providing an introduction to the major political texts written by women during the period of 1400-1800. It will result in the first book-length analysis of the political theories of early modern European women and their influence on European political practice. It will highlight the work of many unjustly neglected female thinkers and contribute to the understanding of European traditions of political justice and the origins of our political institutions.Read moreRead less
Australia's Post World War II War Crimes Trials of Japanese Defendants. Contemporary war crimes trials regularly refer to historical precedent - particularly post-WWII war crimes trials. One virtually unknown group of trials were those conducted by Australian Military Tribunals - the primary sources for which are readily available (Australian War Memorial and National Archives) but under-studied. Australian Tribunals sat in judgment over 814 Japanese Defendants in 296 separate trials and yet th ....Australia's Post World War II War Crimes Trials of Japanese Defendants. Contemporary war crimes trials regularly refer to historical precedent - particularly post-WWII war crimes trials. One virtually unknown group of trials were those conducted by Australian Military Tribunals - the primary sources for which are readily available (Australian War Memorial and National Archives) but under-studied. Australian Tribunals sat in judgment over 814 Japanese Defendants in 296 separate trials and yet there has never been a systematic study of this chapter of Australian Legal and Military History. This project is intended to provide the first study of the trials and will also "unlock" the under-utilised but vast documentary resource for future researchers.Read moreRead less