How organisms coordinate energy supply and demand. The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive unders ....How organisms coordinate energy supply and demand. The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive understanding of the AMP activated protein kinase (enzyme isoforms, genes, physiological roles and regulation). This knowledge will have major benefits in biopharmaceutical development, the livestock, plant and sport/racing industries.Read moreRead less
Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific commun ....Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific community and will be disseminated back to the scientific community, to the humanities and to the Australian public. The project will bring to Australia the strengths of the applicant's existing collaborations with leading research centres in this field in the USA, UK and Canada.Read moreRead less
New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new ....New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new interdisciplinary researchers. It will underpin the National Research Priorities (Frontier Technologies for Building and Transforming Australian Industries, and Promoting and Maintaining Good Health) and help Australia capitalise on a plethora of opportunities for future economic and health benefits.Read moreRead less
Optical Semiconductors for next-generation lasers, optical processors, and integrated optical chips. We are on the verge of an optical processing revolution. The silicon industry evolved from valves to transistors and finally to processors - Optical processing is the next step in the evolution of lasers from gas to solid state, and ultimately to integrated optical chips. Australia had a significant lead in semiconductors during the 1970?s, but unfortunately lost this lead due to a lack of local ....Optical Semiconductors for next-generation lasers, optical processors, and integrated optical chips. We are on the verge of an optical processing revolution. The silicon industry evolved from valves to transistors and finally to processors - Optical processing is the next step in the evolution of lasers from gas to solid state, and ultimately to integrated optical chips. Australia had a significant lead in semiconductors during the 1970?s, but unfortunately lost this lead due to a lack of local market. The emergence of biotechnology and telecommunications offer strong local markets for this new integrated optical technology. This project aims to create a world-leading Research capability in Australia to drive the evolution of integrated optoelectronics, and provide a commercial path to create a leading Australian industry.Read moreRead less
Self, the social body and wellbeing: Embodiment and adaptation in cross-cultural perspective. This interdisciplinary programme will contribute to understanding how ideas of the self, social relationships and their meanings, are revised and restructured as a result of embodied change. Ethonographic research will be conducted with Australian men and women who have had serious chronic illness and surgery, including stroke and kidney disease. Comparative research will be conducted in Thailand, the C ....Self, the social body and wellbeing: Embodiment and adaptation in cross-cultural perspective. This interdisciplinary programme will contribute to understanding how ideas of the self, social relationships and their meanings, are revised and restructured as a result of embodied change. Ethonographic research will be conducted with Australian men and women who have had serious chronic illness and surgery, including stroke and kidney disease. Comparative research will be conducted in Thailand, the Cameroon and Haiti throughcollaborations developed during the Fellowship. The work will contribute to international debates about wellbeing, social capital and resilience in different cultural, social and economic settings.Policy implications relate to community connectedness, health and welfare services, and infrastructure.Read moreRead less