Blocking immune responses: a critical factor in herpesvirus virulence? The horse and poultry industries are two large, primarily rural based livestock production industries that are major contributors to the national economy. The research proposed in this project will improve our understanding of the pathogenesis of two important viral pathogens that are each a significant cost to their respective industry, and thus will ultimately reduce the cost of these two viruses to industry. In addition, ....Blocking immune responses: a critical factor in herpesvirus virulence? The horse and poultry industries are two large, primarily rural based livestock production industries that are major contributors to the national economy. The research proposed in this project will improve our understanding of the pathogenesis of two important viral pathogens that are each a significant cost to their respective industry, and thus will ultimately reduce the cost of these two viruses to industry. In addition, the technology developed during this project would have a global market and may be transferable to other viral pathogens of other domestic species.Read moreRead less
Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a t ....Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a trend to move away from the use of antibiotics in food production animals. Current vaccines are based on inactivated preparations and do not offer a high level of immune protection. Therefore, there is a great need worldwide for a live vaccine for the effective control of Glässer's disease.Read moreRead less