Translation Of Glaucoma Blindness Genes To Improve Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$856,795.00
Summary
Glaucoma is a common cause of irreversible blindness. It is currently difficult to predict which patients with the earliest signs of glaucoma will develop blinding stages of the disease. This study will investigate how genes and eye measurements can be used to predict the risk of developing severe glaucoma in people with early signs of disease. This will ensure that high risk individuals can access treatment early, while those at low risk can be spared unnecessary treatment and seen less often.
Activation Of TERT Gene Expression In Breast Carcinogenesis
Funder
National Health and Medical Research Council
Funding Amount
$693,440.00
Summary
A key step in the development of most cancers is the switching on of an enzyme, telomerase, that allows cancer cells to keep growing without limit. We will study the molecular details of this step using new techniques for functional analyses of the genome in human breast cells grown in the laboratory. Blocking telomerase has great potential for cancer treatment, so analysing how this enzyme gets switched on may identify new strategies for achieving this for breast cancer - and other cancers.
Do Breast Cancer Risk Factors Differ According To Underlying Genetic Susceptibility? A Pooled Analysis Of Prospective Studies From The NCI Cancer Cohort Consortium
Funder
National Health and Medical Research Council
Funding Amount
$418,581.00
Summary
We propose to use data from 23 international prospective cohort studies in the Cancer Cohort Consortium organised by the US National Cancer Institute to evaluate gene environment interactions for women who are at increased genetic risk of breast cancer. Our ultimate goal is to enhance the performance of clinical prediction tools and to develop targeted evidence-based strategies to mitigate the high absolute risk of breast cancer for women at increased genetic risk of the disease.
Advancing the theoretical bases of supply chain management through the lens of relational exchange theory. This project will explain and predict the behaviour of supply chain members better than current theories do. An integrated theory of supply chain management will be developed and tested empirically. This theory will enable better understanding of how supply chains function and guide actions of managers so that the expected benefits are realised.
Synchromodal container logistics for Australia. Synchromodal container logistics for Australia. This project aims to develop advanced mathematical optimization models and algorithms to create multi-modal logistics approaches for container movements in and out of Australia’s busy ports. The increasingly congested capital cities of Sydney, Brisbane and Melbourne need to find new ways of moving an increasing volume of containerized freight. Moving from trucks to rail is expected to reduce pollution ....Synchromodal container logistics for Australia. Synchromodal container logistics for Australia. This project aims to develop advanced mathematical optimization models and algorithms to create multi-modal logistics approaches for container movements in and out of Australia’s busy ports. The increasingly congested capital cities of Sydney, Brisbane and Melbourne need to find new ways of moving an increasing volume of containerized freight. Moving from trucks to rail is expected to reduce pollution and road congestion, but is only possible if highly efficient modes of operation can be developed. Research into system design and operational scheduling is expected to achieve the required efficiency for multi-modal logistics that will reduce air pollution and road congestion.Read moreRead less
Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribut ....Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribution, and delivery of products (smart information use). Improvement in the operational efficiency and performance of the supply chain will increase national wealth while minimising environmental impacts on the environment, for example, through the better utilisation of heavy freight carriers.Read moreRead less
Competitive supplier bidding in supply chains. This project will use mathematical modelling to contribute to better management practice in dealing with procurement. With the increasing use of auctions and sophisticated bidding procedures it is essential to improve our understanding of this important area.
A complete Stochastic Trans-shipment Decision Model (STDM) to assist logistics practitioners to make cost optimised decisions. This project aims to implement a decision-makng model based on a new mathematical theory in dealing with supply and demand problems for businesses. The purpose is to minimise the expected logistics costs for goods trans-shipment operations along the supply chain, thereby maximising profits and enhancing the competitiveness of Australian companies.
Ensuring Australia's competitiveness by implementing targeted performance measurement systems across the extended supply chain. This project will develop a framework to guide managers in designing, implementing, and using performance measurement systems across the industry supply chain to maximise the potential benefits of supply chain management. The outcomes enhance organisational competitiveness, supply chain competitiveness and boost Australia's economy.