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The Effect Of Genetic Polymorphisms On The Development Of Systemic Lupus Erythematosus
Funder
National Health and Medical Research Council
Funding Amount
$50,741.00
Summary
Systemic lupus erythematosus is a debilitating disease that predominantly affects women of child-bearing age and may involve any organ. Genetics is one of the most well-recognised risk factors, and yet how genetics can cause lupus is unclear. This study involves examining the entire genetic sequence of individual patients to identify the mutations that cause the immune system to be dysregulated leading to disease.
Determinants Of Outcomes In SLE: Impact Of Models Of Care, Socioeconomic Factors And Biologic Variables In A Multiethnic Australian Population
Funder
National Health and Medical Research Council
Funding Amount
$134,124.00
Summary
Lupus is a chronic disease where the immune cells attack multiple systems in the body, which can lead to severe organ damage and even death. It is known that genes, socioeconomics and models of care all individually influence the outcomes in lupus. The exact contribution of each one is poorly understood, because they are studied in isolation. This project will take an integrated approach to investigating the factors that influence outcomes in lupus, looking for potentially addressable effects.
Accelerated Telomere Length Attrition Rate In Diabetes And Its Cellular Mechanism
Funder
National Health and Medical Research Council
Funding Amount
$38,381.00
Summary
I am a PhD in Medicine-University of Sydney. My research focus is about telomere dynamic, its mechanism and correlation between telomere length and diabetes attributes. I will compare telomere length between different diabetes groups & examine telomere regulation in cell culture/animal model to compliment my clinical data. The hypothesis: accelerated telomere shortening may co-segregate with diabetes complications and by preserving telomere we could potentially prevent adverse effect of diabetes