The role of HP1 alpha dimerisation in maintaining chromatin structure. Heterochromatin protein 1 alpha (HP1a) is an architectural protein that decorates three-dimensional genome organisation and through self-association into HP1a dimers regulates global gene expression. While there is extensive biochemical evidence on how HP1a molecules bind DNA, dimerise and bridge nucleosomes close together, we still do not know how HP1a regulates higher order chromatin structure in the context of a living cel ....The role of HP1 alpha dimerisation in maintaining chromatin structure. Heterochromatin protein 1 alpha (HP1a) is an architectural protein that decorates three-dimensional genome organisation and through self-association into HP1a dimers regulates global gene expression. While there is extensive biochemical evidence on how HP1a molecules bind DNA, dimerise and bridge nucleosomes close together, we still do not know how HP1a regulates higher order chromatin structure in the context of a living cell. Thus, by use of cutting-edge fluorescence microscopy methods, the overall aim of this research project is to determine the biophysical mechanism by which the HP1a monomer to dimer transition spatially and temporally modulates live cell chromatin network organisation to ensure faithful transmission of the genome.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102210
Funder
Australian Research Council
Funding Amount
$350,333.00
Summary
Feedback control as a tool for enhanced neuroprosthetic stimulation. The aim is to use control theory tools to find optimal stimulation parameters to use in a bionic implant. This project will lead to improvements in understanding of mechanisms underlying electrical stimulation and to improvements in medical bionics technologies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100046
Funder
Australian Research Council
Funding Amount
$289,381.00
Summary
A fast fluorescence lifetime imaging microscope to track protein dynamics. This project aims to establish a fast fluorescence lifetime imaging microscope that can track the intracellular journey of a protein throughout the entire structural framework of a living cell. By coupling single particle tracking technology with a cutting-edge fluorescence lifetime camera, this one-of-a-kind microscope will enable protein mobility and interaction to be spatially mapped with unprecedented temporal resolut ....A fast fluorescence lifetime imaging microscope to track protein dynamics. This project aims to establish a fast fluorescence lifetime imaging microscope that can track the intracellular journey of a protein throughout the entire structural framework of a living cell. By coupling single particle tracking technology with a cutting-edge fluorescence lifetime camera, this one-of-a-kind microscope will enable protein mobility and interaction to be spatially mapped with unprecedented temporal resolution. The benefit of this technology is that it will enable scientists in Australia to image, for the first time, the biophysical mechanism by which a protein navigates intracellular architecture to regulate a complex biological function at the single molecule level.Read moreRead less
Nuclear architecture in a living cell facilitates navigation of the genome. This project aims to investigate the role of nuclear architecture in regulating genome function by development of a new microscopy method to quantify the diffusive route of fluorescent proteins in live cells. The anticipated outcomes of this project include an insight into how chromatin dynamics facilitate DNA target search and an analytical tool for cell biologists to probe how genomes work in their natural environment ....Nuclear architecture in a living cell facilitates navigation of the genome. This project aims to investigate the role of nuclear architecture in regulating genome function by development of a new microscopy method to quantify the diffusive route of fluorescent proteins in live cells. The anticipated outcomes of this project include an insight into how chromatin dynamics facilitate DNA target search and an analytical tool for cell biologists to probe how genomes work in their natural environment (the cell nucleus).Read moreRead less
New entropy measures of short term signals for smart wearable devices. This project aims to improve reliability and accuracy of wearable devices by developing a new set of computationally efficient algorithms. Wearable devices can be very effective in remote and continuous monitoring to detect short or bursty anomalous events. Present devices are unable to detect such events effectively due to limited capability in processing short length signal. This project will provide computationally efficie ....New entropy measures of short term signals for smart wearable devices. This project aims to improve reliability and accuracy of wearable devices by developing a new set of computationally efficient algorithms. Wearable devices can be very effective in remote and continuous monitoring to detect short or bursty anomalous events. Present devices are unable to detect such events effectively due to limited capability in processing short length signal. This project will provide computationally efficient algorithms for signal quality analysis and enhanced feature extraction methods in resource constrained wearable devices. This will improve the reliability and performance of wearable devices for adoption in intelligent decision-making systems.Read moreRead less
Optical wireless communications: solving the spectrum crunch. This project aims to make optical wireless communication to handheld mobile receivers a reality by developing systems which combine holographic filters and microsystems to realise a new form of receiver. This will be based on analysis of all of the complex interactions of transmitter, receiver and channel properties. The new receivers will exploit the narrow field of view of holographic optical filters. This project will generate know ....Optical wireless communications: solving the spectrum crunch. This project aims to make optical wireless communication to handheld mobile receivers a reality by developing systems which combine holographic filters and microsystems to realise a new form of receiver. This will be based on analysis of all of the complex interactions of transmitter, receiver and channel properties. The new receivers will exploit the narrow field of view of holographic optical filters. This project will generate knowledge in the fields of communications theory and on the use of holographic filters and microsystems. This solution to the lack of available radio frequency spectrum which conventional wireless face will provide significant practical and commercial benefits.Read moreRead less
Accurate position estimation using intensity-modulated optical signals. Accurate information about the position of a person or device is essential in many situations. However, despite extensive worldwide research, there is still no positioning system suitable for many important indoor applications. The widespread introduction of energy efficient white light emitting diodes (LEDs) for indoor lighting provides an unprecedented opportunity to solve this problem by using these LEDs to transmit signa ....Accurate position estimation using intensity-modulated optical signals. Accurate information about the position of a person or device is essential in many situations. However, despite extensive worldwide research, there is still no positioning system suitable for many important indoor applications. The widespread introduction of energy efficient white light emitting diodes (LEDs) for indoor lighting provides an unprecedented opportunity to solve this problem by using these LEDs to transmit signals from which a receiver can calculate its position. However the theory underlying the design and analysis of position estimation using modulated optical signals does not exist. This project aims to develop this fundamental theoretical basis and apply it to create the accurate indoor positioning systems of the future.Read moreRead less
A compact microphone array system for outdoor low frequency noise measurements. To investigate the impact of wind farm noise on surrounding communities, the sound level caused by wind turbines must be accurately measured, which sometimes is hard due to wind induced noise and other interference noise. This project aims to propose a novel compact microphone array solution, where the wind induced noise is attenuated by a specially designed windproof shell first, and then the residual wind induced n ....A compact microphone array system for outdoor low frequency noise measurements. To investigate the impact of wind farm noise on surrounding communities, the sound level caused by wind turbines must be accurately measured, which sometimes is hard due to wind induced noise and other interference noise. This project aims to propose a novel compact microphone array solution, where the wind induced noise is attenuated by a specially designed windproof shell first, and then the residual wind induced noise and other interference noise are further filtered out by a specific adaptive noise cancellation algorithm based on the spherical and differential microphone array structure. With the proposed system, the measurement configuration size is expected to be reduced from the current few metres to less than 10 centimetres, and with better accuracy.Read moreRead less
Multi-Modal Dictionary Learning for Smart City Operation and Management. This Project aims to provide new digital asset management tools for city councils to improve city services by utilising new sensing and automated learning technologies for recognising, tracking and auditing of assets. Currently, there are no digital tools available to handle these services. This project proposes new multi-modal sensing and mapping of city asset techniques by building new multi-modal dictionary learning proc ....Multi-Modal Dictionary Learning for Smart City Operation and Management. This Project aims to provide new digital asset management tools for city councils to improve city services by utilising new sensing and automated learning technologies for recognising, tracking and auditing of assets. Currently, there are no digital tools available to handle these services. This project proposes new multi-modal sensing and mapping of city asset techniques by building new multi-modal dictionary learning procedures. The new framework will recognise different conditions of city assets in real-time to make decisions. Expected outcomes of this Project include integration and easy access of assets with unique digital identities to help city councils, governments, and navigation services for real-time asset monitoring.Read moreRead less
A new approach to compressed sensing. Compressed sensing is an exciting new paradigm promising vastly improved signal sampling and reconstruction in a wide variety of applications including digital cameras, mobile phones and MRI machines. This project will explore a newly discovered approach to compressed sensing which uses mathematical arrays known as hash families.