Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Nonlinear Signal Processing: Optimisation and Tracking on Manifolds. Most hi-tech electronic devices must process signals. A mobile phone, for example, must encode, transmit, decode and receive voice signals. This project will use specialised mathematical theories applied in novel ways to advance the theoretical foundations of signal processing and develop better signal processing algorithms for practical applications. Companies with access to better signal processing algorithms have an edge ov ....Nonlinear Signal Processing: Optimisation and Tracking on Manifolds. Most hi-tech electronic devices must process signals. A mobile phone, for example, must encode, transmit, decode and receive voice signals. This project will use specialised mathematical theories applied in novel ways to advance the theoretical foundations of signal processing and develop better signal processing algorithms for practical applications. Companies with access to better signal processing algorithms have an edge over their competitors, and consumers benefit too from better and more advanced products.Read moreRead less
Only recently has it emerged that our cells have a built-in backup mechanism that instructs cells to die in extreme cases, such as when viruses have hijacked a cell. A misfiring backup mechanism is thought to underlie a number of human diseases, including inflammatory disease. Our investigation will establish a starting point for the development of novel anti-inflammatory drugs.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775621
Funder
Australian Research Council
Funding Amount
$494,000.00
Summary
Mileura Widefield Array: A New Low Frequency Telescope. A new radio-quiet site for international radio astronomy is being developed at Mileura in Western Australia. We have constructed a low frequency test array on the site, and established that the site is excellent for radio astronomy. We plan to build a telescope which will observe the early universe, when stars and galaxies where first born. This will be the first telescope capable of this type of measurement of the early universe. In addi ....Mileura Widefield Array: A New Low Frequency Telescope. A new radio-quiet site for international radio astronomy is being developed at Mileura in Western Australia. We have constructed a low frequency test array on the site, and established that the site is excellent for radio astronomy. We plan to build a telescope which will observe the early universe, when stars and galaxies where first born. This will be the first telescope capable of this type of measurement of the early universe. In addition, the telescope will measure the solar wind, and its potential interactions with the earth.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882938
Funder
Australian Research Council
Funding Amount
$1,430,000.00
Summary
MIRA Widefield Array: a new low frequency telescope. A new radio-quiet site for international radio astronomy is being developed at Boolardy in Western Australia. We have constructed a low frequency test array on the site, and established that the site is excellent for radio astronomy. We plan to build a telescope which will observe the early universe, when stars and galaxies where first born. This will be the first telescope capable of this type of measurement of the early universe. In additi ....MIRA Widefield Array: a new low frequency telescope. A new radio-quiet site for international radio astronomy is being developed at Boolardy in Western Australia. We have constructed a low frequency test array on the site, and established that the site is excellent for radio astronomy. We plan to build a telescope which will observe the early universe, when stars and galaxies where first born. This will be the first telescope capable of this type of measurement of the early universe. In addition, the telescope will measure the solar wind, and its potential interactions with the Earth. Read moreRead less
New targets for antiviral therapies. The ability of dangerous viruses to cause lethal disease depends on their capacity to evade the immune system of infected hosts. This project will uncover at the molecular level the strategies used by viruses to disable immune responses; this will identify new ways to treat incurable diseases, by disabling the virus' defences against the immune system.
ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this te ....ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this team with the foremost international authorities and leading industry players in the area of sensor networks. This research network will guide collaborative research that will ensure Australia to play a world leading role in sensor network development and implementation.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100011
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Integrated Multimodal System for Multiplexed Imaging of Signal Transduction. This project will introduce a unique microscopy platform and associated technologies into the Australian research environment that will enable researchers to redefine our understanding of molecular signal transduction. The instrumentation will enable the multidimensional imaging of live cells with unprecendented speed and sensitivity. The featured imaging modalities will enable the integration of distinct biological, ....Integrated Multimodal System for Multiplexed Imaging of Signal Transduction. This project will introduce a unique microscopy platform and associated technologies into the Australian research environment that will enable researchers to redefine our understanding of molecular signal transduction. The instrumentation will enable the multidimensional imaging of live cells with unprecendented speed and sensitivity. The featured imaging modalities will enable the integration of distinct biological, biochemical and chemical probes with a focus on minimizing phototoxicity. Expected outcomes include new fundamental knowledge on molecular signal transduction and cell heterogeneity; development of novel probes and methodologies and the development of new and existing interdisciplinary research collaborations. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100046
Funder
Australian Research Council
Funding Amount
$289,381.00
Summary
A fast fluorescence lifetime imaging microscope to track protein dynamics. This project aims to establish a fast fluorescence lifetime imaging microscope that can track the intracellular journey of a protein throughout the entire structural framework of a living cell. By coupling single particle tracking technology with a cutting-edge fluorescence lifetime camera, this one-of-a-kind microscope will enable protein mobility and interaction to be spatially mapped with unprecedented temporal resolut ....A fast fluorescence lifetime imaging microscope to track protein dynamics. This project aims to establish a fast fluorescence lifetime imaging microscope that can track the intracellular journey of a protein throughout the entire structural framework of a living cell. By coupling single particle tracking technology with a cutting-edge fluorescence lifetime camera, this one-of-a-kind microscope will enable protein mobility and interaction to be spatially mapped with unprecedented temporal resolution. The benefit of this technology is that it will enable scientists in Australia to image, for the first time, the biophysical mechanism by which a protein navigates intracellular architecture to regulate a complex biological function at the single molecule level.Read moreRead less
Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preven ....Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preventative health perspective, the investigation of platelet calcium signalling will greatly accelerate the development of new pharmaceuticals to tackle acute and chronic cardiovascular diseases, such as stroke, heart attack and artherosclerosis. Read moreRead less