Development of an active noise control system for sleeper seats on large commercial aircraft. Possible avenues will be investigated to actively reduce aircraft cabin noise experienced by passengers in sleeper seats, using localised active noise control (ANC). Previous work has focused on headsets and upright seat headrests which represent a different problem to the partially enclosed sleeper seats considered here. Efficiency and robustness problems that affect existing ANC systems will be addres ....Development of an active noise control system for sleeper seats on large commercial aircraft. Possible avenues will be investigated to actively reduce aircraft cabin noise experienced by passengers in sleeper seats, using localised active noise control (ANC). Previous work has focused on headsets and upright seat headrests which represent a different problem to the partially enclosed sleeper seats considered here. Efficiency and robustness problems that affect existing ANC systems will be addressed. A prototype system will be produced for a business class sleeper seat in a wide body aircraft. A second outcome is the establishment of a robust integrated system design procedure that can be used to quickly develop ANC systems for future designs.Read moreRead less
Raising the Internet's Quality of Service through improved congestion management. This project aims to develop methods for improving the service quality of the internet by better management of congestion. Improved service quality will be evident to internet users in the form of reduced delay and data loss. The proposed research is significant because as well as improving service quality, it will facilitate delivery of internet services over poor quality communications infrastructure such as is p ....Raising the Internet's Quality of Service through improved congestion management. This project aims to develop methods for improving the service quality of the internet by better management of congestion. Improved service quality will be evident to internet users in the form of reduced delay and data loss. The proposed research is significant because as well as improving service quality, it will facilitate delivery of internet services over poor quality communications infrastructure such as is present in many remote and regional areas of Australia. It also will result in more efficient utilisation of telecommunications infrastructure. The project will deliver implementations in the form of software which is easily installed in any computer.Read moreRead less
Data Fusion Techniques for Electro-Mechanical Braking Systems. The main focus of this project is to develop data fusion techniques for clamp force estimation and optimum utilisation of redundant information in a brake-by-wire system. Efficient integration of redundant information in an EMB system is expected to significantly improve the reliability and fault tolerance of such systems. The need for costly and complicated clamp force measurement sensors in electric callipers will also be eliminate ....Data Fusion Techniques for Electro-Mechanical Braking Systems. The main focus of this project is to develop data fusion techniques for clamp force estimation and optimum utilisation of redundant information in a brake-by-wire system. Efficient integration of redundant information in an EMB system is expected to significantly improve the reliability and fault tolerance of such systems. The need for costly and complicated clamp force measurement sensors in electric callipers will also be eliminated by accurate estimation of the clamp force signal, through fusion of more readily available measurements. Development of the proposed data fusion techniques influences the design of future EMBs and enhances the functionality of existing brake-by-wire systems.Read moreRead less
Understanding The Role Of The Atypical Cadherin Fat4 In Lymphatic Vascular Development
Funder
National Health and Medical Research Council
Funding Amount
$1,006,248.00
Summary
This application will define the role of a large cell adhesion molecule, FAT4, in lymphatic vascular development. By understanding how FAT4 functions in lymphatic vessels, we will gain insight to the mechanisms by which mutations in the gene that encodes this protein cause a human lymphoedema syndrome.
How IsomiRs Expand The MicroRNA Functional Repertoire In Affecting Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$439,570.00
Summary
MicroRNAs function as regulators of gene expression. It is becoming appreciated that microRNAs are frequently expressed as variants with subtly different sequences. We find here that variation in one important cancer-associated microRNA, miR-222, promotes differences in the behaviour of cells expressing them. This work seeks to understand how microRNA variation confers such properties to cells, to identify the genes miR-222 variants regulate, and to examine how widespread it is that microRNA var ....MicroRNAs function as regulators of gene expression. It is becoming appreciated that microRNAs are frequently expressed as variants with subtly different sequences. We find here that variation in one important cancer-associated microRNA, miR-222, promotes differences in the behaviour of cells expressing them. This work seeks to understand how microRNA variation confers such properties to cells, to identify the genes miR-222 variants regulate, and to examine how widespread it is that microRNA variation contributes to cancer.Read moreRead less
A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to ....A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.Read moreRead less
Targeting Sphingosine Kinase 1 To Sensitise Acute Myeloid Leukaemia To BH3 Mimetic Therapy
Funder
National Health and Medical Research Council
Funding Amount
$670,005.00
Summary
Acute Myeloid Leukaemia (AML) patients are currently treated with chemotherapeutics and despite their success at achieving disease remission these responses are often short lived, resulting in relapse and death. We have identified sphingosine kinase 1 as a new drug target in AML. This proposal aims to examine the role of targeting sphingosine kinase 1 in combination with new targeted therapies in patient samples and preclinical mouse models of AML.
Towards Distributed Phased Array Radar for High Resolution Weather Monitoring. Several recent reports on climate change by leading international and national bodies forecast that the rate of weather hazards such as storms and wind-shear, and of weather-associated phenomena such as bush fires will increase over the next 40 years. The current technology for monitoring weather events, and effects like wind-shift, which has a serious impact on dangers associated with bush fires, has significant wea ....Towards Distributed Phased Array Radar for High Resolution Weather Monitoring. Several recent reports on climate change by leading international and national bodies forecast that the rate of weather hazards such as storms and wind-shear, and of weather-associated phenomena such as bush fires will increase over the next 40 years. The current technology for monitoring weather events, and effects like wind-shift, which has a serious impact on dangers associated with bush fires, has significant weaknesses. We will deliver considerable improvements in monitoring capability by developing the technology for using a network of small phased array radars. We aim to place monitoring resources where end-user needs are greatest.Read moreRead less
Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level ....Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level of the individual to isolated enteroendocrine cells.Read moreRead less
Protecting Critical Transport Infrastructure using Hybrid Approaches for Interference and Spoofer Detection and Localisation. Modern infrastructure increasingly relies on the positioning and timing capabilities provided by the Global Navigation Satellite Systems (GNSS). GNSS signals, however, are vulnerable to interference and spoofing attacks. This vulnerability is aggravated as satellite navigation becomes more central to the operation of airports, ports, railways, and communications systems. ....Protecting Critical Transport Infrastructure using Hybrid Approaches for Interference and Spoofer Detection and Localisation. Modern infrastructure increasingly relies on the positioning and timing capabilities provided by the Global Navigation Satellite Systems (GNSS). GNSS signals, however, are vulnerable to interference and spoofing attacks. This vulnerability is aggravated as satellite navigation becomes more central to the operation of airports, ports, railways, and communications systems. Building on from earlier work by University of New South Wales, University of Adelaide and GPSat Systems, this project aims to create a system for locating interference and spoofers to GNSS of any power in real time, providing layered monitoring and reactive mitigation solutions against interference and spoofing attacks.Read moreRead less