Statistical analyses for spatial organisation in T cell signalling networks. This project aims to reveal how nanoscale spatial organisation encodes plasticity in the T cell signalling network, and how T cells exploit this plasticity to regulate sensitivity to antigens. In adoptive immunity, T cells respond appropriately to any given antigen, but how they make decisions is unclear. This project will define how nanoscale spatial organisation of signalling molecules shapes signalling strength and p ....Statistical analyses for spatial organisation in T cell signalling networks. This project aims to reveal how nanoscale spatial organisation encodes plasticity in the T cell signalling network, and how T cells exploit this plasticity to regulate sensitivity to antigens. In adoptive immunity, T cells respond appropriately to any given antigen, but how they make decisions is unclear. This project will define how nanoscale spatial organisation of signalling molecules shapes signalling strength and plasticity in the T cell antigen receptor (TCR) network; and infer rules linking spatial organisation and signalling activities in intact T cells. Contextualising the TCR signalling network is expected to reveal the origin and use of network plasticity for T cell decision-making. Such information could be invaluable for the design of vaccines and immune-modulating drugs.Read moreRead less
Estimation and Control of Noisy Riemannian Systems. Many application areas such as satellite control, computer vision, coordination of rigid bodies, require the estimation and control of systems subject to geometric constraints. Most current algorithms for doing this are deterministic and can fail catastrophically in the presence of noise. This project aims to provide:
(i) Methods for analysing and then redesigning deterministic algorithms to ensure stability in the presence of noise;
(ii) New ....Estimation and Control of Noisy Riemannian Systems. Many application areas such as satellite control, computer vision, coordination of rigid bodies, require the estimation and control of systems subject to geometric constraints. Most current algorithms for doing this are deterministic and can fail catastrophically in the presence of noise. This project aims to provide:
(i) Methods for analysing and then redesigning deterministic algorithms to ensure stability in the presence of noise;
(ii) New design methods that deal with noise in an optimal way;
(iii) Noise resistant methods for distributed consensus seeking systems and cooperative control systems.
The outcomes will advance and benefit spatio-temporal data analysis and coordination in areas such as transport, health and video-security.Read moreRead less
Point processes system identification under simultaneity. Neuroscientists study neuronal brain dynamics of mammals via recordings from scores of tiny electrodes. But analysing these experiments is a problem because current methods cannot handle the common case where neurons discharge simultaneously. This project aims to provide powerful new tools to overcome this bottleneck.
Riemannian System Identification. A growing number of applications such as satellite attitude estimation, pose estimation in computer vision and direction estimation in statistics require the study of random processes in Riemannian manifolds and Lie Groups. This project will provide: methods for the construction/ numerical simulation of such processes; methods of system identification and their asymptotic performance analysis; and, algorithms for process state estimation.
Modeling stochastic systems in Riemannian manifolds. This project aims to develop new statistical signal processing and control engineering algorithms and tools that will enable tracking of objects remotely on land and in space. A growing number of applications require the study of random processes in Riemannian manifolds, that is processes that evolve subject to a geometric constraint. This project aims to provide methods for the numerical simulation of such processes, methods of online and off ....Modeling stochastic systems in Riemannian manifolds. This project aims to develop new statistical signal processing and control engineering algorithms and tools that will enable tracking of objects remotely on land and in space. A growing number of applications require the study of random processes in Riemannian manifolds, that is processes that evolve subject to a geometric constraint. This project aims to provide methods for the numerical simulation of such processes, methods of online and offline system identification from data on such processes and asymptotic performance analysis; and algorithms for process state estimation that obeys the geometry. The outcomes will advance and benefit spatio-temporal data analysis in areas such as transport, health and video-security.Read moreRead less
Vector network system identification. This machine learning project aims to provide more reliable ways to identify the structure and function of dynamic networks from both continuous and discrete network data. The project will use all the data and create principled new metrics. This could enable early diagnosis of network faults across a range of applications for example in power systems or diseased human brains. It could also enable discovery of critical functional subnetworks affecting reliabl ....Vector network system identification. This machine learning project aims to provide more reliable ways to identify the structure and function of dynamic networks from both continuous and discrete network data. The project will use all the data and create principled new metrics. This could enable early diagnosis of network faults across a range of applications for example in power systems or diseased human brains. It could also enable discovery of critical functional subnetworks affecting reliable operation in large complex human systems (such as financial systems) or natural systems (such as gene regulatory networks).Read moreRead less