Development of an active noise control system for sleeper seats on large commercial aircraft. Possible avenues will be investigated to actively reduce aircraft cabin noise experienced by passengers in sleeper seats, using localised active noise control (ANC). Previous work has focused on headsets and upright seat headrests which represent a different problem to the partially enclosed sleeper seats considered here. Efficiency and robustness problems that affect existing ANC systems will be addres ....Development of an active noise control system for sleeper seats on large commercial aircraft. Possible avenues will be investigated to actively reduce aircraft cabin noise experienced by passengers in sleeper seats, using localised active noise control (ANC). Previous work has focused on headsets and upright seat headrests which represent a different problem to the partially enclosed sleeper seats considered here. Efficiency and robustness problems that affect existing ANC systems will be addressed. A prototype system will be produced for a business class sleeper seat in a wide body aircraft. A second outcome is the establishment of a robust integrated system design procedure that can be used to quickly develop ANC systems for future designs.Read moreRead less
Premature birth is a major cause of neonatal death and intellectual and other handicaps among the survivors. While neonatal intensive care has improved the survival of premature babies, there has been no reduction in the number of premature babies born, in fact the numbers are increasing. Our inability to reduce premature birth is partly related to our lack of knowledge of the physiological processes that lead to normal labour. As a result many of our drugs for women in premature labour are not ....Premature birth is a major cause of neonatal death and intellectual and other handicaps among the survivors. While neonatal intensive care has improved the survival of premature babies, there has been no reduction in the number of premature babies born, in fact the numbers are increasing. Our inability to reduce premature birth is partly related to our lack of knowledge of the physiological processes that lead to normal labour. As a result many of our drugs for women in premature labour are not very effective. We have recently identified a novel pathway that regulates the activity of the muscle cells that form the uterus. This project seeks to understand the biochemical processes that change a muscle cell so that it begins to contract actively at the end of pregnancy. Specifically the project will examine two proteins called HSP20 and HSP27. These proteins have recently been reported to play a critical role in the contraction and relaxation of smooth muscle cells in the heart and blood vessels. We have identified for the first time that these proteins are also present in the muscle of the human uterus. It is likely that they play a critical role in regulating the contractions of the uterus. By understanding this process better we may be able to design better treatments to prevent premature birth.Read moreRead less
Premature birth is a major cause of neonatal death and intellectual and other handicaps among the survivors. While neonatal intensive care has improved the survival of premature babies, there has been no reduction in the number of premature babies born, in fact the numbers are increasing. Our inability to reduce premature birth is partly related to our lack of knowledge of the physiological processes that lead to normal labour. As a result many of our drugs for women in premature labour are not ....Premature birth is a major cause of neonatal death and intellectual and other handicaps among the survivors. While neonatal intensive care has improved the survival of premature babies, there has been no reduction in the number of premature babies born, in fact the numbers are increasing. Our inability to reduce premature birth is partly related to our lack of knowledge of the physiological processes that lead to normal labour. As a result many of our drugs for women in premature labour are not very effective. Our work has shown that a hormone called corticotrophin releasing hormone (CRH) made in the placenta plays a critical role in determining the length of a pregnancy. We have measured the levels of this hormone in the blood of pregnant women and shown that it increases more rapidly than normal in women who deliver prematurely and more slowly than normal in women who deliver late. It acts as a kind of clock to determine the length of pregnancy. What is not known is how this hormone acts to bring on labour. What is particularly puzzling is that some of the actions of the CRH seem likely to cause the uterus to relax rather than to contract. We wish to test the idea that the rapidly rising levels of this hormone in late pregnancy cause changes in the uterus that stop the pathways to relaxation and lead to contraction. To perform these studies we will use small pieces of uterus donated with informed consent from women undergoing caesarean section. The results of these studies may allow us to design better ways of preventing premature birth and prevent many cases of cerebral palsy and intellectual handicap.Read moreRead less
Single-cell Optical Window Imaging In CDK1-FRET Biosensor Mice To Assess Tissue Stiffness And Optimise Delivery And Therapeutic Response To Gemcitabine/Abraxane In Pancreatic Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$676,979.00
Summary
Inefficient drug response in solid tumour tissue is commonly a limiting factor in the clinical effectiveness of cancer therapies. Using cutting-edge imaging technology and 3D models that mimic the disease, we have mapped areas of poor drug response within distinct regions of tumours. Here, we pinpoint and specifically target key factors limiting efficient drug targeting in order to improve the encouraging anti-cancer profile of the new drug combination Gemcitabine/Abraxane in pancreatic cancer.
Biosensor Imaging In Preclinical Pancreatic Cancer Targeting: Taking Cancer Targeting To New Dimensions.
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
Using cutting-edge imaging technology and 3D models that mimic cancer, we can map areas of poor drug response within distinct 'stages' or regions of tumours. Here, we pinpoint and specifically target key factors limiting efficient drug response in order to improve the encouraging anti-cancer profile of new or current drugs in pancreatic cancer.
Joint modelling and recognition of linguistic and paralinguistic speech information. A new modelling framework will be developed exploiting interdependence between linguistic and paralinguistic cues to improve automatic recognition of emotion-related information. Applications in the high-tech industry include automatic routing of angry telephone customers or pre-suicidal crisis centre callers to specialist operators/clinicians.
This project will test if the ratio of the two different estrogens found in the blood of pregnant women is the critical factor in determining the onset of contractions in the uterus at labour. The studies will also determine the role of a newly discovered receptor for estrogens in allowing powerful contractions at labour. Results will allow development of new treatments to prevent premature birth that block the actions of estrogen at this new receptor or change the ratio of the two estrogens.
A unified framework for analyzing the timescale of interest for traffic measurements, modelling and performance analysis. The revenue generated from traditional telecommunication services is continuing to drop. New value-added services such as multimedia services become the fastest growing revenue-generating sector in Australia's telecommunications industry. The ubiquitous presence of scaling behaviour in network traffic presents a big challenge for delivering better Quality-of-Service (QoS) whi ....A unified framework for analyzing the timescale of interest for traffic measurements, modelling and performance analysis. The revenue generated from traditional telecommunication services is continuing to drop. New value-added services such as multimedia services become the fastest growing revenue-generating sector in Australia's telecommunications industry. The ubiquitous presence of scaling behaviour in network traffic presents a big challenge for delivering better Quality-of-Service (QoS) which is demanded by the new services. A complete understanding of the scaling behaviour and its impact is very important. This research addresses a key problem of defining the timescale range of interest for the scaling behaviour. The research outcome benefits a number of areas, which are all critical for developing enhanced QoS support and better network management.Read moreRead less
Scaling Up Satellite Communications for the Internet of Things. The Internet of Things (IoT) is a revolution in sensing and automation that is becoming vital for industries including farming and mining. However, in remote areas, it is especially challenging to connect the large numbers of devices needed. This project will develop novel signal processing and communications approaches to deliver high quality data services to vast numbers of remote IoT devices, distributed over continental scales c ....Scaling Up Satellite Communications for the Internet of Things. The Internet of Things (IoT) is a revolution in sensing and automation that is becoming vital for industries including farming and mining. However, in remote areas, it is especially challenging to connect the large numbers of devices needed. This project will develop novel signal processing and communications approaches to deliver high quality data services to vast numbers of remote IoT devices, distributed over continental scales connected via low earth orbit (LEO) satellite constellations. It will provide the tools for LEO satellite service providers to dimension their networks and assist IoT providers to scale their remote sensor networks and IoT deployments, with ever increasing demand on the limited satellite bandwidth.Read moreRead less