L-amino Acid Sensing By The Extracellular Calcium-sensing Receptor: Molecular, Cellular And In Vivo Studies
Funder
National Health and Medical Research Council
Funding Amount
$362,545.00
Summary
Recent work by Dr Conigrave and colleagues demonstrates for the first time that protein and calcium metabolism are linked at the molecular level by the widely distributed calcium-sensing receptor. The project will aim to demonstrate the physiological significance of this finding by testing whether L-amino acids, the building blocks of body protein, exert receptor-dependent control over the secretion and blood levels of hormones that regulate body calcium levels. It will further test the hypothes ....Recent work by Dr Conigrave and colleagues demonstrates for the first time that protein and calcium metabolism are linked at the molecular level by the widely distributed calcium-sensing receptor. The project will aim to demonstrate the physiological significance of this finding by testing whether L-amino acids, the building blocks of body protein, exert receptor-dependent control over the secretion and blood levels of hormones that regulate body calcium levels. It will further test the hypothesis by determining whether amino acids exert receptor-dependent control over the proliferation of bone forming cells and urinary excretion of calcium.Read moreRead less
Benefits Of Intravenous L-Carnitine Supplementation In Long-Term Haemodialysis Patients
Funder
National Health and Medical Research Council
Funding Amount
$406,648.00
Summary
Carnitine allows the body to utilise fats in our diet, permitting normal functioning of the body. The applicants have shown that patients who receive long-term haemodialysis treatment have abnormal levels of carnitine and have demonstrated a link between these abnormal levels and some dialysis-related conditions. This study will determine whether supplementation with L-carnitine is beneficial in the treatment of some clinical disorders experienced by haemodialysis patients.