Molecular Targets Involved In Human Muscle Atrophy And Hypertrophy
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Muscle wasting is a consequence of aging, cancer, HIV-AIDS, obesity and work-sport injuries. It increases the risk of injury, impacts on recovery and places an economic burden on our healthcare system. Atrogin-1 and STARS are muscle specific genes believed to regulate muscle mass. This project aims to determine how human atrogin-1 and STARS are regulated and how they can influence muscle loss. These studies may provide new targets for reducing human muscle wasting.
In Vivo Responses To Pathogen-derived Mediators Of Acute Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$94,250.00
Summary
Sepsis causes large numbers of deaths worldwide. It is not known why some patients tolerate an infection and fully recover, while other patients with an equivalent infection are highly vulnerable to severe illness and death from sepsis. Heart failure is a common underlying condition in sepsis. This research will focus on how an infection can cause sudden cardiac death. It will have implications for care of patients with severe infection and also sudden infant death syndrome.
Addressing Important Evidence Gaps In The Management Of Severe Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$256,839.00
Summary
There are currently large gaps in the evidence base for management of common severe bacterial infections. My research plan focuses on the most common of these: Staphylococcus aureus infections, bone and joint infections, skin infections, and severe sepsis. In order to both generate important evidence to inform practice, as well as to develop my own skills and experience as an expert in clinical trials, I have initiated randomised controlled trials in each of these areas.
Immunological Mechanisms And Management Of Serious Illness And Injury
Funder
National Health and Medical Research Council
Funding Amount
$334,539.00
Summary
This fellowship will improve outcomes for seriously ill and injured people, in particular anaphylaxis (life-threatening severe allergy), sepsis (infection) and severe brain injury. Novel laboratory research will be brought to the emergency bedside and integrated with clinical trials aimed at improving outcomes from these conditions. As well as providing immediate benefits in terms of understanding disease processes, this research will pave the way for new therapeutic approaches in the future.