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Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Carbohydrates and Carbohydrate-Recognising Proteins as Drug Discovery Targets. The significance and roles of carbohydrates in many biological processes, in particular those processes associated with disease, is now well-recognised. These new directions have captured the attention and imagination of not only academic research groups across the world, but also pharmaceutical and biotechnology companies and has restimulated their interest in the pursuit of carbohydrate-based drugs and drugs against ....Carbohydrates and Carbohydrate-Recognising Proteins as Drug Discovery Targets. The significance and roles of carbohydrates in many biological processes, in particular those processes associated with disease, is now well-recognised. These new directions have captured the attention and imagination of not only academic research groups across the world, but also pharmaceutical and biotechnology companies and has restimulated their interest in the pursuit of carbohydrate-based drugs and drugs against carbohydrate-recognising proteins critical in disease processes. The current application seeks to use some of this information to faciliate the discovery of novel carbohydrate-based chemical entities as inhibitors of the spread of some cancers and diseases caused by pathogenic microorganisms.Read moreRead less