Role Of The CD8-Heparan Sulfate Interaction In CD8+ T Cell Development And Function
Funder
National Health and Medical Research Council
Funding Amount
$649,135.00
Summary
The immune system can recognise a large array of foreign pathogens without reacting to self-components. For this to occur T cells, the main mediators of immunity, must be made to tolerate self-molecules as they develop in the thymus. We have identified a novel interaction between a molecule called CD8 on T cells and a complex carbohydrate called heparan-sulfate, which helps auto-reactive T cells to be eliminates in the thymus. The aim of this project is to further investigate this phenomenon.
Quantitative genetic control of economic traits in Eucalyptus globulus. Eucalyptus globulus is the most important plantation eucalypt in Australia and a model for tree genetic research. The project aims to study the quantitative genetic architecture of this species, focusing on traits of economic significance, and provide new insights into: the relative importance of non-additive genetic effects, including maternal and reciprocal effects; the importance of indirect genetic effects, particularly ....Quantitative genetic control of economic traits in Eucalyptus globulus. Eucalyptus globulus is the most important plantation eucalypt in Australia and a model for tree genetic research. The project aims to study the quantitative genetic architecture of this species, focusing on traits of economic significance, and provide new insights into: the relative importance of non-additive genetic effects, including maternal and reciprocal effects; the importance of indirect genetic effects, particularly on the competitive interactions amongst trees; and the genetics of traits impacting the production of emerging plantation products such as veneer. This information is needed to improve genetic evaluation models and to better target germplasm to environments and products.Read moreRead less
Germinal Centres, Rogue B Cells And The Genesis Of Immunological Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
This study will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in autoimmune diseases such as lupus. Targeted studies of a newly discovered "rogue" white blood cell will also provide new clues on how autoimmune diseases arise. In addition, modeling of human immunological disease in mice via CRISPR/Cas9 mutagenesis will provide valuable new insights into their causes and potential treatments.
Positive And Negative Selection In The Germinal Centre Reaction
Funder
National Health and Medical Research Council
Funding Amount
$1,289,965.00
Summary
We will investigate the processes that control the production of antibodies by the immune system. In particular, we will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in the case of autoimmune diseases such as lupus. Targeted studies of a new type of "rogue" white blood cell we have identified will also provide important clues on how autoantibody-producing cells escape and cause autoimmune disease.
Maximising pineapple production for Australian farmers using genome editing. This project addresses the single biggest issue affecting the viability of pineapple farming in Australia and internationally: premature flowering leading to supply collapse. We aim to develop CRISPR technology to breed new pineapple varieties using non-GM approaches. Expected outcomes include the production of pineapples with resistance to premature flowering, as well as the technologies to deliver additional improveme ....Maximising pineapple production for Australian farmers using genome editing. This project addresses the single biggest issue affecting the viability of pineapple farming in Australia and internationally: premature flowering leading to supply collapse. We aim to develop CRISPR technology to breed new pineapple varieties using non-GM approaches. Expected outcomes include the production of pineapples with resistance to premature flowering, as well as the technologies to deliver additional improvements in the future. The new varieties will benefit farmers through increased production, maximising supply capability for a rapidly growing internal demand. This will benefit Australian pineapple producers through higher profitability in existing markets, as well as enabling expansion into international and future markets.Read moreRead less
The Cellular And Molecular Basis To The Paradox Of Positive Versus Negative T Cell Selection
Funder
National Health and Medical Research Council
Funding Amount
$278,090.00
Summary
The protection against disease requires the generation of white blood cells called T lymphocytes that are produced in the thymus. Each T cell has a specific surface receptor, generated by random gene switching, that can react against foreign pathogens. Since there is a very high conservation of molecules used in all organisms, some of these receptors could by chance also react against normal cells in the host. Eliminating all such self-reactive cells would mean, however, the repertoire remaining ....The protection against disease requires the generation of white blood cells called T lymphocytes that are produced in the thymus. Each T cell has a specific surface receptor, generated by random gene switching, that can react against foreign pathogens. Since there is a very high conservation of molecules used in all organisms, some of these receptors could by chance also react against normal cells in the host. Eliminating all such self-reactive cells would mean, however, the repertoire remaining for eliminating infection would be too low and immunodeficiency develops. This project investigates the mechanisms controlling the balance between defence infection and the need to prevent immune-based self destruction termed autoimmunity.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454133
Funder
Australian Research Council
Funding Amount
$101,000.00
Summary
Upgrade of Infrared Analytical Facility. This application seeks funding to upgrade the existing infrared analytical facility in the Central Science Laboratory (CSL) by installing a near infrared analyser.This instrument will provide analytical support to researchers in the fields of silviculture, agriculture and chemistry by providing a low cost, rapid and accurate analysis of the chemical and physical properties of large sample numbers.This instrument will dramatically reduce the project costs, ....Upgrade of Infrared Analytical Facility. This application seeks funding to upgrade the existing infrared analytical facility in the Central Science Laboratory (CSL) by installing a near infrared analyser.This instrument will provide analytical support to researchers in the fields of silviculture, agriculture and chemistry by providing a low cost, rapid and accurate analysis of the chemical and physical properties of large sample numbers.This instrument will dramatically reduce the project costs, compared with traditional wet analytical methods,and enable larger and statistically more significant data sets to be acquired.The expected outcomes will include a more rapid identification of the genes controlling plant characteristics and the development of targeted plant breeding programs of economic significance to Australia.The development of specific resins for gold extraction will be both economically and environmentally important.Read moreRead less