Role Of The CD8-Heparan Sulfate Interaction In CD8+ T Cell Development And Function
Funder
National Health and Medical Research Council
Funding Amount
$649,135.00
Summary
The immune system can recognise a large array of foreign pathogens without reacting to self-components. For this to occur T cells, the main mediators of immunity, must be made to tolerate self-molecules as they develop in the thymus. We have identified a novel interaction between a molecule called CD8 on T cells and a complex carbohydrate called heparan-sulfate, which helps auto-reactive T cells to be eliminates in the thymus. The aim of this project is to further investigate this phenomenon.
Germinal Centres, Rogue B Cells And The Genesis Of Immunological Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
This study will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in autoimmune diseases such as lupus. Targeted studies of a newly discovered "rogue" white blood cell will also provide new clues on how autoimmune diseases arise. In addition, modeling of human immunological disease in mice via CRISPR/Cas9 mutagenesis will provide valuable new insights into their causes and potential treatments.
Positive And Negative Selection In The Germinal Centre Reaction
Funder
National Health and Medical Research Council
Funding Amount
$1,289,965.00
Summary
We will investigate the processes that control the production of antibodies by the immune system. In particular, we will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in the case of autoimmune diseases such as lupus. Targeted studies of a new type of "rogue" white blood cell we have identified will also provide important clues on how autoantibody-producing cells escape and cause autoimmune disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347358
Funder
Australian Research Council
Funding Amount
$478,000.00
Summary
Adelaide high-speed cell sorter and analyser facility. Cell sorting and flow cytometric analysis represent powerful and essential tools in modern cell and molecular biology. The applicants seek to develop a core facility within Adelaide University housing a high-speed Fluorescence Activated Cell Sorter and a high-speed flow cytometric analyser. Such a facility is not currently available to researchers in Adelaide. These high-speed machines will allow studies on rare cells and subcellular compon ....Adelaide high-speed cell sorter and analyser facility. Cell sorting and flow cytometric analysis represent powerful and essential tools in modern cell and molecular biology. The applicants seek to develop a core facility within Adelaide University housing a high-speed Fluorescence Activated Cell Sorter and a high-speed flow cytometric analyser. Such a facility is not currently available to researchers in Adelaide. These high-speed machines will allow studies on rare cells and subcellular components, currently not possible on other machines and meeting the demand for access to this sophisticated equipment is vital for cell and molecular biologists in Adelaide to continue advances in genomics and proteomics.Read moreRead less