Targeting Lipid Signalling Receptors To Promote Remyelination In Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$925,907.00
Summary
Multiple sclerosis is caused by the immune system mistakenly attacking and depleting myelin, the fatty substance that insulates neurons in our nervous system. To improve MS therapy and open up the possibility for functional recovery, we must develop drugs that protect and regenerate myelin. We will define how the loss of certain key biochemical signals promotes myelin loss in MS, and how drugs that restore those signals may be used to protect and regenerate myelin in people with the disease.
Reversing Age-related Impairment Of Myelin Repair - A Novel Therapy For MS
Funder
National Health and Medical Research Council
Funding Amount
$1,053,161.00
Summary
Multiple sclerosis (MS) is a disease of the brain and spinal cord caused by the loss of myelin which normally insulates the axons (cables) of nerve cells. When myelin is lost, electrical signals cannot pass along axons normally. Regenerating this myelin is key to restoring normal nerve function but myelin repair deteriorates with age. We will determine whether age-associated decline in myelin repair can be reversed by rejuvenating the myelin repair process.