Improving Outcomes For Individuals And Families Affected By Genetic Disease.
Funder
National Health and Medical Research Council
Funding Amount
$838,845.00
Summary
I aim to reduce illness and death caused by inherited diseases, particularly in unborn children, newborns and infants. I will do this by finding causes of inherited diseases we don’t yet know, investigating treatments for inherited diseases and developing better methods of diagnosing inherited diseases. I will also investigate methods of finding carriers of recessive diseases before they have affected children, so that they can avoid having children affected with severe diseases.
Utility Of Genetic Screening For Colorectal Cancer Risk Assessment
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Bowel cancer can be prevented by regular screening, however screening is not targeted to those most at risk and only 30% take up the offer. My research will determine how effective genetic testing of the general population might be as an innovative approach to target screening to those most at risk. I will use data from existing and funded studies that I lead, and will collaborate with colleagues in my research team that have the necessary expertise in this area, to address this question issue.
Research Fellowship In Preventing HIV And HIV-related Cancer
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
This fellowship concerns HIV prevention and HIV-related cancer. In HIV prevention, Grulich will evaluate the success of elements of the new biomedical prevention approach to HIV, and highlight areas in which policy action can be taken to substantially reduce HIV transmission. In HIV related cancer, Grulich will determine whether HIV-associated cancers continue to occur at increased rates in the new era of prolonged survival of people with HIV, and investigate preventive approaches.
The Prevention And Control Of Sexually Transmitted Infections In Australia
Funder
National Health and Medical Research Council
Funding Amount
$590,785.00
Summary
The increasing sexually transmitted infection diagnoses in Australia have considerable public health implications and there are still many questions about the most effective way to prevent and control their transmission. The goal of my fellowship is to build on my existing program of research and generate new evidence to further our understanding of the epidemiology of these infections and identify the most effective ways for their prevention and control.
Nigel G Laing, NH&MRC Principal Research Fellowship: Neurogenetics – Gene Discovery, Pathobiology, Novel Therapeutics, Novel Diagnostics And Translation.
Funder
National Health and Medical Research Council
Funding Amount
$880,454.00
Summary
My Fellowship will expand my work identifying diseases genes for genetic muscle and nerve diseases by using new technologies that allow discovery of human disease genes which could not be found before. In addition, since we now have proof from mouse studies that heart actin is a target for therapy for the group of diseases that we discovered caused by mutations in the muscle actin protein, we shall take further steps towards making this therapy a reality for patients.
Ion channels are molecular pores of excitable membranes facilitating passage of ions and organic solutes across cellular membranes. An ever-increasing number of human and animal diseases result from malfunctioning ion channels making them to important therapeutic targets, which are modulated by a range of currently prescribed drugs. In the recent years the scientific and medical community has become increasingly aware of the role that mechanosensitive ion channels play in pathology of diseases i ....Ion channels are molecular pores of excitable membranes facilitating passage of ions and organic solutes across cellular membranes. An ever-increasing number of human and animal diseases result from malfunctioning ion channels making them to important therapeutic targets, which are modulated by a range of currently prescribed drugs. In the recent years the scientific and medical community has become increasingly aware of the role that mechanosensitive ion channels play in pathology of diseases including cardiac hyperthrophy and arrhythmias.Read moreRead less
Genetics And Genomics Of Breast And Ovarian Cancer
Funder
National Health and Medical Research Council
Funding Amount
$714,745.00
Summary
Our knowledge of the number and nature of the genes involved in breast and ovarian cancer is limited. To rapidly define the critical breast and ovarian cancer-causing genes my laboratory uses an integrative genomics approach whereby information from several genome-wide platforms are combined. A key initiative that will underpin much of our work is Lifepool, which is a unique cohort of 100,000 Victorian women attending BreastScreen that will support a range of research into breast cancer.