THE EFFECT OF STRESS AND ENVIRONMENTAL ENRICHMENT ON DISEASE PROGRESSION IN MESIAL TEMPORAL LOBE EPILEPSY
Funder
National Health and Medical Research Council
Funding Amount
$578,201.00
Summary
Mesial temporal lobe epilepsy, the most common form of drug-resistant epilepsy in adults, is a progressive neurodegenerative condition for which there is currently no effective disease modifying treatment. This proposal will explore whether co-morbid stress accelerates disease progression in MTLE, and whether targeting stress pathways by medical and environmental manipulations can mitigate against this.
Discovery Early Career Researcher Award - Grant ID: DE160101047
Funder
Australian Research Council
Funding Amount
$337,118.00
Summary
The Effectiveness of Global Sexual Rights Policy in Education. This project plans to explore the usefulness and harmfulness of global rights-based policy processes for gay, lesbian, bisexual, transgender, intersex and queer students. New global sexual rights policies for schools and related transnational processes paradoxically appear to have contributed to the criminalisation of (and even capital punishment for) education on homosexuality in several countries. This project intends to map the or ....The Effectiveness of Global Sexual Rights Policy in Education. This project plans to explore the usefulness and harmfulness of global rights-based policy processes for gay, lesbian, bisexual, transgender, intersex and queer students. New global sexual rights policies for schools and related transnational processes paradoxically appear to have contributed to the criminalisation of (and even capital punishment for) education on homosexuality in several countries. This project intends to map the order and movement of transnational discourses about these students in global education policies and processes, consider how they reflect different regions' perspectives, and compare them to localised approaches. The knowledge from the project is expected to inform policy processes.Read moreRead less
School autonomy reform and Australian public education. This project aims to provide an evidence base for policymakers and practitioners that articulates how Australian public schools at an individual and system level engage with school autonomy reform. The project expects to generate an evidence base and new knowledge in the form of dilemma cases, position papers and a practice framework to support social justice through school autonomy reform. This evidence base will produce national economic ....School autonomy reform and Australian public education. This project aims to provide an evidence base for policymakers and practitioners that articulates how Australian public schools at an individual and system level engage with school autonomy reform. The project expects to generate an evidence base and new knowledge in the form of dilemma cases, position papers and a practice framework to support social justice through school autonomy reform. This evidence base will produce national economic and social benefits for Australian communities by identifying the requisite knowledge and practices that will enable key stakeholders to mobilise school autonomy in ways that produce just outcomes for all students.Read moreRead less
A socio-cultural analysis of eating disorders among pre-teen boys and girls. This project tackles the tough question of why there has been a dramatic increase in eating disorders amongst very young boys and girls by examining the social conditions of children's lives in contemporary Australia. The findings will provide important information for policy makers, educators and clinicians working with children and families.
The Effect Of Stress And Hypercortisolaemia On Limbic Epileptogenesis & Affective Disorder.
Funder
National Health and Medical Research Council
Funding Amount
$380,714.00
Summary
This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxiety and depression) and temporal lobe epilepsy (TLE) - the most common form of medical refractory epilepsy in the community. Up to 50% of patients with TLE suffer from anxiety and-or depression. Until relatively recently it had been widely assumed that this was a consequence of the chronic epileptic condition. However, recent evidence suggests that there is ....This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxiety and depression) and temporal lobe epilepsy (TLE) - the most common form of medical refractory epilepsy in the community. Up to 50% of patients with TLE suffer from anxiety and-or depression. Until relatively recently it had been widely assumed that this was a consequence of the chronic epileptic condition. However, recent evidence suggests that there is a bi-directional relationship, with the psychiatric conditions and stress also acting to aggravate the seizures and even predispose to the development of the epilepsy itself. Apart from gaining insights into causes of TLE, anxiety and depression, this framework has potential public health relevance suggesting approaches to the eventual primary and secondary prevention of both MTLE and its associated psychiatric co-morbidities, a neglected area at present. The use of an animal model allows investigation of aetiological processes that extend over the lifetime, which is exceptionally difficult to achieve in humans. Retrospective studies, such as case-control studies, although an indispensable research methods, are subject to bias and imprecision when it comes to measuring remote past exposures to stress, abuse, and deprivation. If the results of these experiments are consistent with our hypotheses, a very strong case would exist for exploring this relationship in human studies. The data would also provide a strong rationale for more aggressive detection and treatment of these psychiatric co-morbidities in TLE patients, in order to potentially modify the progression of the disorder as well as improve the quality of life of sufferers. The results of intervention studies in animal models may suggest specific mode of treatment to achieve this.Read moreRead less
Young children in digital society: An Online Tool for service provision . This project aims to identify the practices enacted and shared amongst young children, their families and educators in digital society.The project is significant because in digital society families and educators face new demands ensuring technologies are used in the best interests of young children. Knowledge about practices in digital society informs adult decision-making using technologies with, by and for young children ....Young children in digital society: An Online Tool for service provision . This project aims to identify the practices enacted and shared amongst young children, their families and educators in digital society.The project is significant because in digital society families and educators face new demands ensuring technologies are used in the best interests of young children. Knowledge about practices in digital society informs adult decision-making using technologies with, by and for young children in the early years. The outcome is a new Online Tool for the Partner Organisations to share exemplar practices benefiting Australian children, their families and educators with new resources, materials and programs in areas including: digital media production, cyber-safety education, digital play and digital parenting.
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The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.