I have discovered particular factors produced by our white blood cells have the ability to shut down or boost protein production in the gut, pancreas and lung. My vision is to harness these to devise new strategies for treatments for infectious and non-infectious diseases (inflammatory bowel disease, diabetes) that have a high burden on our healthcare system.
Preventing Suicide In Young People: A Public Health Approach
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Suicide is the leading cause of death in young Australians. This fellowship aims to lower risk for suicide by testing: a) whether improving the connectedness of adolescents in schools can improve help-seeking, b) whether parents can learn to recognise risk in their children, and c) whether school screening is an appropriate and effective strategy to reduce risk. Practical outcomes will be new programs for youth, new strategies for parents and a better integrated approach for Australian schools.
Understanding The Development Of Dental Fear Among Australian Children And Adults By Applying A Comprehensive Conceptual Model
Funder
National Health and Medical Research Council
Funding Amount
$418,482.00
Summary
Dental fear acts as a significant barrier to obtaining dental care, and leads to poorer dental health, greater dental treatment needs and reduced school and work performance. Approximately 1 in 7 children and adults have high dental fear. Understanding how dentists are being trained, what they are doing in their dental practise, and how and why dental fear develops and is maintained, are fundamental steps in trying to reduce this important dental, mental, and public health issue.
This proposal aims to examine central mechanisms important in stress related hypertension. My team will focus on the role of tissue plasminogen activator in mediating inhibitory effects of chronic stress on neural plasticity and examine inhibitory dysfunction in GABAergic and nitric oxide pathways that lead to increased sympathetic activity and elevated blood pressure. Importantly, we will investigate the potential of three interventions directed at each as therapies for hypertension.
Innovative And Multi-disciplinary Treatment Strategies For Secondary Degeneration Following Neurotrauma
Funder
National Health and Medical Research Council
Funding Amount
$455,452.00
Summary
Following injury to the central nervous system the damage spreads into nearby areas, leading to worse outcomes for the patient. The research conducted during this Fellowship will ensure that promising treatment strategies to prevent spreading damage are used in the best way, and will determine the mechanism of action of these treatments.
Targeting The Class IIa Histone Deacetylases In Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Dysfunctional metabolism in skeletal muscle is integral in the development of metabolic diseases, such as obesity and type 2 diabetes. This project will examine proteins that alter the way genes are expressed for their role in dysfunctional metabolism in muscle. This project could uncover new therapies for the treatment of metabolic diseases.
Trauma And Recovery: Understanding And Treating Posttraumatic Stress Disorder In Refugees
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Refugees report high rates of posttraumatic stress disorder (PTSD), however, a lack of understanding of the processes underlying refugee mental health has limited the effective treatment of this disabling disorder. My research program will overcome these barriers by uncovering core mechanisms and developing a targeted intervention to reduce PTSD symptoms in refugees. My research will advance knowledge about refugee mental health, and inform best-practice clinical care of refugees.
Understanding The Link Between Mitochondrial Biogenesis And Disease
Funder
National Health and Medical Research Council
Funding Amount
$421,055.00
Summary
As the predominate energy producers of our cells, mitochondria are implicated in a variety of diseases. To function properly, these dynamic organelles rely on protein components that regulate their structure and distribution throughout the cell. My work aims to expand our knowledge of the way these components control mitochondrial shape and trafficking. By understanding the correlation between mitochondrial morphology and function, we will gain insight into related diseases.