Antipsychotic Medication In First-episode Psychosis: An RCT To Assess The Risk-benefit Ratio
Funder
National Health and Medical Research Council
Funding Amount
$1,141,117.00
Summary
There has been an increasing emphasis on intervening early in psychotic disorders. A fundamental principle in early intervention is “to do no harm” and benefits must outweigh the risks of treatment. While antipsychotic medication is very effective and evidence-based form of treatment for positive symptoms in most first episode psychosis (FEP) patients it has risks. This study has the potential to determine whether antipsychotic medication should be the initial treatment option for FEP.
PSYSCAN— Translating Neuroimaging Findings From Research Into Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$376,285.00
Summary
Our ability to predict the onset and outcome of schizophrenia and other psychotic disorders remains limited. This restricts the implementation of effective preventative and early interventions. This project will rectify this by developing a tool of significant clinical utility. The project has 2 aims: 1. To develop and validate a neuroimaging-based tool for use in early psychosis to assist with early diagnosis, outcome, and disease progression. 2. To apply the tool in clinical practice.
Long-term Outcome Of Individuals Who Had A First-episode Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$1,344,905.00
Summary
The long-term illness course and outcomes of patients treated for first episode psychosis are poorly understood especially in terms of important domains such as social and vocational functioning, physical health, and quality of life. This treated cohort study of a sample of 786 patients, 15 years after their first episode of psychosis will be one of the longest and largest conducted to date. Results of the study will inform clinical practice and policy development.
Functional Neuroimaging Of Prepulse Inhibition In Schizophrenia And Parkinson's Disease
Funder
National Health and Medical Research Council
Funding Amount
$446,750.00
Summary
Inhibition deficits have been consistently demonstrated in a broad spectrum of neuropsychiatric conditions that have been implicated with altered neurotransmitter function of the brain. These conditions include mental disorders like schizophrenia, obsessive-compulsive disorder, and pathological gambling and neurological disorders like Huntington's disease, Gilles-de-la-Tourette syndrome and other conditions which are characterised by impaired impulse control. Studies on animal models suggest tha ....Inhibition deficits have been consistently demonstrated in a broad spectrum of neuropsychiatric conditions that have been implicated with altered neurotransmitter function of the brain. These conditions include mental disorders like schizophrenia, obsessive-compulsive disorder, and pathological gambling and neurological disorders like Huntington's disease, Gilles-de-la-Tourette syndrome and other conditions which are characterised by impaired impulse control. Studies on animal models suggest that an impaired dopamine neurotransmission - either genetically pre-determined and-or stress-induced by environmental factors - may significantly contribute to a common pathological mechanism across these conditions that, in turn, results in impaired 'sensory motor gating', a physiological measure of inhibitory brain processes. Traditionally, sensory motor gating is indirectly measured using the acoustic startle eye-blink response. However, this peripheral measure cannot directly assess the brain processes underlying sensory motor gating. This study will apply new functional brain imaging methodology and EEG-based source localisation techniques to assess the neural substrates of inhibitory processes involved in sensory motor gating in two neuropsychiatric conditions that involve dysfunctional dopaminergic mechanisms: schizophrenia and Parkinson's disease.Read moreRead less
Molecular And Cellular Characterisation Of Schizophrenia Associated Dysfunction In MicroRNA Biogenesis
Funder
National Health and Medical Research Council
Funding Amount
$496,205.00
Summary
We have identified substantial changes in the biogenesis of microRNA in schizophrenia. These small non-coding molecules derived from junk DNA, play a significant role in genetic regulation, with each one capable of silencing hundreds of target genes. This has major implications for schizophrenia, which is known to involve substantial changes in gene activity. The project will identify the molecular basis of this alteration in gene silencing, and its biological implications for schizophrenia.
Identifying Endophenotypes For Schizophrenia And Autism: A Support Vector Machine Learning Approach
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Schizophrenia and autism are mental health problems that often occur together. Despite this, little is known about the overlap between them and how to treat people who experience both. In this study, I will compare young adults with schizophrenia and autism using three measures of brain function. I plan to employ complex statistical analyses to better understand the similarities and differences between the disorders in order to improve diagnosis and treatment.
Randomised Controlled Trial Of Cognitive Behaviour Therapy To Prevent Psychosis Among People With At-risk Mental States.
Funder
National Health and Medical Research Council
Funding Amount
$619,604.00
Summary
Recent advances in the accurate identification of individuals at high risk of developing a psychotic disorder, such as schizophrenia, have inspired the development of interventions designed to delay, ameliorate or even prevent the onset of such disorders. To date, the results of only three randomised controlled trials of such interventions have been published. Although these results have shown that interventions are able to delay the onset of psychosis, and may even prevent psychosis in some cas ....Recent advances in the accurate identification of individuals at high risk of developing a psychotic disorder, such as schizophrenia, have inspired the development of interventions designed to delay, ameliorate or even prevent the onset of such disorders. To date, the results of only three randomised controlled trials of such interventions have been published. Although these results have shown that interventions are able to delay the onset of psychosis, and may even prevent psychosis in some cases, it is unclear which treatment should be preferred for this population because the three trials have assessed, respectively, a combination of anti-psychotic medication and cognitive behaviour therapy (CBT), CBT alone, and anti-psychotic medication alone. Since the trial of CBT alone produced results that were at least as favourable as the two other trials, and since ethical and clinical objections have been raised concerning the use of anti-psychotic medications with young people who may never develop a psychotic disorder, CBT may be the preferred treatment. Far from posing unnecessary risks, CBT has the potential to provide important therapeutic benefits even to those not destined to develop a psychosis. The current study is significant in that it proposes a controlled trial of a form of CBT which has been specially adapted for preventing transition to psychosis among young high-risk individuals, to test whether the previous favourable results for CBT can be independently replicated. It will be compared with a control treatment. Since cannabis abuse is common among young people who are at risk, and is a known risk factor for psychosis, CBT will include elements of treatment for cannabis abuse. The trial will be run in both Newcastle and Orange, NSW, enabling us to compare the effectiveness of CBT in urban and rural settings. This study has the potential to have large impacts on the quality of life of young people at risk of psychosis.Read moreRead less
Childhood Cognitive Antecedents Of Adult Psychopathology: Follow-up Of The Port Pirie Lead Cohort Into Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$587,263.00
Summary
The role of childhood factors in the development of adult psychiatric disorder is an important public health concern. Indvividuals identified before birth and followed across the life course offer the most powerful means of establishing predictors for particular types of psychiatric disorder. Not only do these studies enable researchers to more clearly determine the exact age of onset of disorder but they also give us insight into the background and hence possible risk factors that may have lead ....The role of childhood factors in the development of adult psychiatric disorder is an important public health concern. Indvividuals identified before birth and followed across the life course offer the most powerful means of establishing predictors for particular types of psychiatric disorder. Not only do these studies enable researchers to more clearly determine the exact age of onset of disorder but they also give us insight into the background and hence possible risk factors that may have lead to the development of that disorder. Early identification of disorder can significantly reduce public health cost and reduce the burden on the community by enabling individuals to get help before their symptoms become too severe and unmanageable. Few long-term studies have investigated the combined role of pre-natal, developmental, parental characteristics, biological and childhood cognitive risk factors in the development of adult psychiatric dysfunction. Even fewer studies have examinined this interrelationship in a group of individuals who have been exposed to an environmental toxin such as lead. This study will follow-up 723 adults from the lead smelting city of Port Pirie who were originally recruited between 1979 and 1982. All adults were exposed to lead to some degree in childhood and have been followed over various time points over the course their lives. This project will be conducted 27 years since they were first involved, and will hence be one of the longest studies to be conducted in this field. The extensive information already collected on this group of individuals will enable us to create a very comprehensive picture of risk and protective factors for various types of adult disorder.Read moreRead less