Brain disorders are a major public health and economic problem. Study of brain tissues from deceased patients using current technologies has great potential to unlock our understanding of how these diseases occur and may lead to improvements in diagnosis, treatment or the development of preventative strategies. The furthering of this knowledge as new technologies come on-line justifies the need to develop a National Network devoted to storage and provision of carefully characterised brain tissue ....Brain disorders are a major public health and economic problem. Study of brain tissues from deceased patients using current technologies has great potential to unlock our understanding of how these diseases occur and may lead to improvements in diagnosis, treatment or the development of preventative strategies. The furthering of this knowledge as new technologies come on-line justifies the need to develop a National Network devoted to storage and provision of carefully characterised brain tissue to neuroscientists.Read moreRead less
Molecular Mechanisms Leading To Schizophrenia- The Role Of Estrogen And Estrogen Receptor Alpha
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Schizophrenia (SZ) is a devastating mental illness of unknown cause thought to arise from a derailment of normal brain development where the brain fails to respond to the pubertal surge in sex steroids. This proposal aims to determine the molecular pathogenesis of SZ. The SZ susceptibility gene estrogen receptor alpha and the SZ susceptibility pathway neuregulin-ErbB4 are interrogated. This will lead to the development of novel therapeutics and preventative agents that will halt disease onset.