Roles Of Annexins In Schistosome Surface Homeostasis And Host-parasite Interactions
Funder
National Health and Medical Research Council
Funding Amount
$612,885.00
Summary
With the increasing occurrence of the debilitating tropical disease schistosomiasis due to climate change, novel therapeutics are in demand. Current therapies rely on treatment with a single drug, and require repeated application. In this timely study, we will elucidate the role of surface-associated proteins, hypothesised to be the crucial stabilising factor in the body wall of the blood-feeding worm schistosome that protects the parasite. Targetting these proteins will lead to new therapeutics ....With the increasing occurrence of the debilitating tropical disease schistosomiasis due to climate change, novel therapeutics are in demand. Current therapies rely on treatment with a single drug, and require repeated application. In this timely study, we will elucidate the role of surface-associated proteins, hypothesised to be the crucial stabilising factor in the body wall of the blood-feeding worm schistosome that protects the parasite. Targetting these proteins will lead to new therapeutics against schistosomiasis.Read moreRead less