A study of the archaeology of Caucasian Iberia with implications for grazing management in Australia. This multi-disciplinary project will promote a younger generation of talented postgraduate and undergraduate students in a wide variety of fields, including archaeology, geomatic engineering, conservation of material culture, environmental and other natural sciences. The highlands of the Caucasus, located in a bioclimatic zone with a long history of alpine grazing, can also provide answers to qu ....A study of the archaeology of Caucasian Iberia with implications for grazing management in Australia. This multi-disciplinary project will promote a younger generation of talented postgraduate and undergraduate students in a wide variety of fields, including archaeology, geomatic engineering, conservation of material culture, environmental and other natural sciences. The highlands of the Caucasus, located in a bioclimatic zone with a long history of alpine grazing, can also provide answers to questions such as the effect of grazing on biodiversity and the rehabilitation of fragile ecosystems, which may inform management and conservation activities in analogous highland country in Australia. The project will also ensure that exhibitions illustrating the rich heritage of Caucasus will reach Australian shores.Read moreRead less
Dhenia: A study of regionalism, population and society in Bronze Age Cyprus. The cemetery complex at Dhenia in Cyprus was in use for 2500 years, from the beginning of the Bronze Age (2,400 BCE) to the end of the Iron Age. This project is designed to sample this extensive site to assess its changing size and structure during periods of major social transformation. Comparative studies of contemporary sites will provide the basis for monitoring and explaining local, regional and island-wide relatio ....Dhenia: A study of regionalism, population and society in Bronze Age Cyprus. The cemetery complex at Dhenia in Cyprus was in use for 2500 years, from the beginning of the Bronze Age (2,400 BCE) to the end of the Iron Age. This project is designed to sample this extensive site to assess its changing size and structure during periods of major social transformation. Comparative studies of contemporary sites will provide the basis for monitoring and explaining local, regional and island-wide relationships, viewed in a context of expanding population and increasing interaction with the wider Mediterranean world. New data and approaches will contribute significantly to Cypriot archaeology and to broader archaeological theory.Read moreRead less
In the Wake of the Sea Peoples, In the Footsteps of Goliath: Excavating the Philistine Site of Tell es-Safi/Gath. This project brings Australian research into the current scholarly debates on Philistine identity, a quickly growing sub-discipline in Mediterranean archaeology. Marginalized in the Bible as decadent, current research sees the Philistines as a cosmopolitan culture resulting from migration from Cyprus and the Aegean, and interaction with the local Canaanite population. In addition, Au ....In the Wake of the Sea Peoples, In the Footsteps of Goliath: Excavating the Philistine Site of Tell es-Safi/Gath. This project brings Australian research into the current scholarly debates on Philistine identity, a quickly growing sub-discipline in Mediterranean archaeology. Marginalized in the Bible as decadent, current research sees the Philistines as a cosmopolitan culture resulting from migration from Cyprus and the Aegean, and interaction with the local Canaanite population. In addition, Australian collaboration and interaction with Israeli colleagues and students will contribute to a more positive perception of the Jewish community in Australia, which has been the recent target of anti-Semitic activities as a result of the Israeli government's invasion of Gaza.Read moreRead less
Settlement patterns, craft production, and the rise of early states in China. This project is an international, multidisciplinary archaeological program focused on monitoring the processes which led to the rise of early states in China, through extensive study of settlement patterns in the Yiluo valley, using regional surveys and geoarchaeological investigations. It will make significant contributions in four aspects: evaluation and reformulation of general theoretical and methodological approac ....Settlement patterns, craft production, and the rise of early states in China. This project is an international, multidisciplinary archaeological program focused on monitoring the processes which led to the rise of early states in China, through extensive study of settlement patterns in the Yiluo valley, using regional surveys and geoarchaeological investigations. It will make significant contributions in four aspects: evaluation and reformulation of general theoretical and methodological approaches to the interdisciplinary study of social complexity; enhanced understanding of Chinese cultural history in the light of anthropological theory; articulation of empirical approaches to the study of Chinese civilisation through archaeology; and strengthened collaborative research between archaeologists in Australia and other parts of the world.Read moreRead less
Special Research Initiatives - Grant ID: SR0354580
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible ....Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible responses to the challenge of creating sustainable societies in a changing world. Through a greater understanding of past societies' reactions to rapid environmental change, the Network will build on existing leading edge research and create a more informed guide to a sustainable future.Read moreRead less
Technological Advances in Large-scale Roman Concrete Buildings during the 2nd and 1st centuries BC. How were the Romans able to build monuments which are still standing after 2,000 years? Skills to achieve this were clearly not developed overnight. A multidisciplinary team from the University of Melbourne has identified the 1st century BC as a time of tremendous technological change in Roman architecture. Was it that the Romans used a technologically advanced type of concerete? Was it that they ....Technological Advances in Large-scale Roman Concrete Buildings during the 2nd and 1st centuries BC. How were the Romans able to build monuments which are still standing after 2,000 years? Skills to achieve this were clearly not developed overnight. A multidisciplinary team from the University of Melbourne has identified the 1st century BC as a time of tremendous technological change in Roman architecture. Was it that the Romans used a technologically advanced type of concerete? Was it that they had perfected the structural design of vaults and domes? Was it simply their organisational ability or the enormous wealth which flowed from their vast Empire? A team of experienced archaeologists,architects and engineers seeks to answer these questions by survey and material analysis of a number of key Roman monuments.Read moreRead less
Finding The Genetic Causes Of Asthma: The Australian Asthma Genetics Consortium (AAGC)
Funder
National Health and Medical Research Council
Funding Amount
$1,697,639.00
Summary
Asthma is a major burden on individuals and health systems. Despite many decades of research, no major effective new treatments for asthma have emerged recently. We will establish a large international consortium to systematically test nearly all known human genes to identify those that influence asthma susceptibility. We expect to identify pathways not previously implicated in asthma and so lead to a potential breakthrough in the development of more effective treatments.
Antigen Selection In The MHC-restricted Cellular Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$175,570.00
Summary
The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally appare ....The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally apparent when molecules called antigens are released by microorganisms and captured by the body's cells. This activates lymphocytes resulting in an immune response capable of eliminating the microorganisms. Scrutiny of the body's cells by lymphocytes occurs continuously even when there is no infection present in the body. Following infection of a cell, microbial antigens reveal the infection by their appearance on the cell surface where they are detected by the immune system's lymphocytes. This occurs through a mechanism called antigen presentation. During antigen presentation the proteins inside the cell, including those of any invading microorganism, are first degraded into shorter molecules called peptides. This event is called antigen processing. A fraction of the peptides created by antigen processing are captured by specialised receptors present on all cells. These receptors are called HLA or histocompatibility molecules. This project examines the molecular events which mediate the capture of peptide antigens by HLA molecules. The main focus is on those peptide antigens which elicit killer T cell responses by the immune system. A knowledge of how these peptides are selected for presentation and how they are captured and carried to the cell surface is fundamental to understanding immune responses to microorganisms, tumours, allergens, transplants and self tissues as in autoimmunity. Therefore the study is of great general relevance.Read moreRead less
Clinical Genetic Phenotyping Of Autism Spectrum Disorders
Funder
National Health and Medical Research Council
Funding Amount
$582,114.00
Summary
Individuals with autism spectrum disorders (ASD) have difficulty with communication, social interaction and intellectual disability. The cause is generally not known although most cases have a genetic basis involving multiple genes and possibly environmental factors. We will study families of children with ASD and carefully characterize features related to ASD in family members. This will help us to understand how ASD is inherited and serve as the basis for the discovery of autism genes.
The Role Of Non-classical MHC Class I Molecules In Adaptive Immunity
Funder
National Health and Medical Research Council
Funding Amount
$443,834.00
Summary
Specialised proteins called MHC class Ia molecules (MHC-Ia) stimulate killer T cells to lyse virus infected cells. In contrast, the function of the closely related MHC-Ib is uncertain. Recent findings have demonstrated that MHC-Ib can also be recognised by T cells and this interaction is important in the control of viral infections. However, despite the similarity to MHC-Ia, it is unclear how this interaction occurs. This project aims to investigate how killer T cells recognise MHC-Ib molecules.