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Novel Mechanisms Of Early Age Related Macular Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$933,953.00
Summary
Age Related Macular degeneration (AMD) is a leading cause of blindness in Australia. In this project we will examine a novel mechanism by which the cells at the back of the eye, called retinal pigment eptihelial cells contribute to vision loss early in the disease. In addition we will examine the potential for two currently used drugs as well as a novel laser treatment in slowing the progression of disease.
The Role Of Estrogen Signalling In The Development And Progress Of Neovascularisation In Macular Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Age-related macular degeneration is a common eye disease. In the advanced stages of the disease, abnormal and leaky blood vessels form, causing permanent and severe vision loss. A novel treatment is the application of the sex hormone, estrogen, which could halt abnormal blood vessel growth in the eye. This project aims to confirm the protective effects of estrogen on eye health and whether mutations in estrogen-related genes alter the risk of vision loss due to abnormal blood vessel growth.
The Role Of Microglia In Regulating Photoreceptor Integrity
Funder
National Health and Medical Research Council
Funding Amount
$556,405.00
Summary
This project will examine a novel way that photoreceptors in the eye are regulated. In particular, the communication between resident immune cells and photoreceptors will be examined. The results will form an important foundation on which to develop novel treatments for diseases like Age Related Macular Degeneration.