Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a bas ....Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a base template for novel nanosilver engineering with less tendency for resistance development and to facilitate tracking of resistance and its spread amongst microorganisms. The knowledge has far-reaching implications on the better governance of nanosilver use, including its disposal.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Elemental release and oxidant production from mixed coal mine dusts. The aim of this project is to understand the implications of physical and chemical characteristics of mixed coal mine dusts to their elemental release and oxidant production. The re-emergence of occupational lung diseases in recent years has revealed a major knowledge gap in the area of respirable particle reactivity. This research will examine the role between coal mine dust and their capacity to produce reactive oxygen specie ....Elemental release and oxidant production from mixed coal mine dusts. The aim of this project is to understand the implications of physical and chemical characteristics of mixed coal mine dusts to their elemental release and oxidant production. The re-emergence of occupational lung diseases in recent years has revealed a major knowledge gap in the area of respirable particle reactivity. This research will examine the role between coal mine dust and their capacity to produce reactive oxygen species, with the focus being on the role of physical and chemical properties of particles and how they transform with age. The findings will be used to develop screening protocols and develop novel monitoring / mitigation strategies for coal mine workers.Read moreRead less
Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This proje ....Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This project will rank Australian climate-sensitive/heat attributable diseases by their current burden and projected increase under climate changes, and provide needed scientific evidence to policy-makers in the development, prioritization and implementation of current and future climate change and health adaptation strategies. Read moreRead less
Making Australia resilient to airborne infection transmission. The COVID-19 pandemic demonstrated that basic questions regarding how to minimise the risk of airborne infection transmission for any respiratory viruses remain unanswered, despite their frequency and huge social and economic costs. Therefore, this project aims to expand scientific knowledge and develop practical tools to improve the resilience of Australian indoor environments against airborne transmission of respiratory viruses. T ....Making Australia resilient to airborne infection transmission. The COVID-19 pandemic demonstrated that basic questions regarding how to minimise the risk of airborne infection transmission for any respiratory viruses remain unanswered, despite their frequency and huge social and economic costs. Therefore, this project aims to expand scientific knowledge and develop practical tools to improve the resilience of Australian indoor environments against airborne transmission of respiratory viruses. The outcomes of the project conducted by a multidisciplinary international team of collaborators will include: (i) quantitative knowledge on virus-laden aerosols from human expiration; and (ii) exposure and infection risk models and their application to typical indoor building and transport scenarios.Read moreRead less
Bushfires, smoke, and people: assessing the risks and benefits from planned burning on the urban-rural interface. A key strategy to protect people from wildfire is the use of planned burns to reduce fire hazards. The exposure of communities to smoke pollution is a serious side-effect of this intervention. This project will be critical in enabling authorities to protect public health by determining acceptable levels of smoke originating from planned burns.
Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidi ....Multi-Country Study on Health Effects of Bushfire Air Pollution. Catastrophic bushfires are a major natural disaster, causing serious air pollution. However, aligning bushfire air pollution and public health policies becomes a significant challenge, because limited studies are available on relationships between bushfire air pollution and human health, particularly for the prolonged exposure. We will characterize the nature of the relationships between bushfire air pollution and mortality/morbidity by developing a multi-country study; and estimate the burden of diseases attributed to bushfire air pollution. This project will provide essential scientific evidence to policy-makers and stakeholders in the development, prioritization and implementation of health protection strategies and policies.
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The unfolding story of the 2009 Adelaide heatwave: risk factors for mortality and morbidity. This project will conduct a case control study in Adelaide to explore the risk factors of extra health burden related to the 2009 heatwave. Given the prediction of more extreme heat events, this study will provide important information for policy makers and service providers to assist in the development of more resilient communities to climate change.