Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100137
Funder
Australian Research Council
Funding Amount
$881,758.00
Summary
Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-fun ....Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-funded resource for integrated exposure research into the future. The archive is expected to support longitudinal and cross-sectional studies to assess trends in exposure to chemical and biological hazards in the Australian population, identify emerging hazards, and provide a scientific basis for policy and regulatory actions.Read moreRead less
Understanding and controlling bioavailability: passive dosing of persistent organic pollutants into recombinant cell bioassays. Bioassays with mammalian cell lines may replace animal testing in chemical risk assessment if issues with limited sensitivity can be overcome for very hydrophobic chemicals such as polychlorinated dibenzodioxins. The project will solve this problem by developing a polymer-release dosing technique that assures defined and constant exposure.
Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-spe ....Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-specific chemical exposures in Australia, and globally. Such data are critical to inform public health and chemical regulation policy, and provide clear guidance aimed at reducing exposures, to assess the effectiveness of existing regulations, and provide a framework for implementing surveys in the future.Read moreRead less
A novel path to environmental and human health risk assessment of transformation products. Chemical pollution is a threat to our rivers and drinking water supplies. Degradation during water treatment and in the environment may lead to persistent and toxic transformation products. This project will provide a practical and cost-efficient risk assessment strategy for transformation products - to help ensure that our drinking water is safe.
Understanding third hand exposure of Australian people to methamphetamine. In Australia, there is high community concern around inadvertent exposure to methamphetamine residues in contaminated houses. In this proposal, an interdisciplinary research team aim to engage with public health authorities and public housing industry to conduct collaborative research on total exposure to methamphetamine in contaminated indoor environments. The project will assess exposure pathways (via air, dust, surface ....Understanding third hand exposure of Australian people to methamphetamine. In Australia, there is high community concern around inadvertent exposure to methamphetamine residues in contaminated houses. In this proposal, an interdisciplinary research team aim to engage with public health authorities and public housing industry to conduct collaborative research on total exposure to methamphetamine in contaminated indoor environments. The project will assess exposure pathways (via air, dust, surfaces) and link them with methamphetamine levels in samples from occupants (urine, hair). The project is expected to significantly enhance our understanding of how third hand exposure leads to internal exposure in humans. This knowledge provides evidence for policies on residential indoor exposures and remediation strategies.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100028
Funder
Australian Research Council
Funding Amount
$2,854,682.00
Summary
Transforming our understanding of the chemical exposome. Despite many benefits associated with the use of chemicals, there is consensus that their accelerated production and use is increasingly affecting environmental health. Effective tools to understand spatiotemporal trends and factors that drive chemical exposure are urgently needed. This project aims to develop these tools by combining established programs in systematic sampling and archiving with advanced informatics and analytical techniq ....Transforming our understanding of the chemical exposome. Despite many benefits associated with the use of chemicals, there is consensus that their accelerated production and use is increasingly affecting environmental health. Effective tools to understand spatiotemporal trends and factors that drive chemical exposure are urgently needed. This project aims to develop these tools by combining established programs in systematic sampling and archiving with advanced informatics and analytical techniques. The project expects to identify emerging chemicals of concern, assess factors that affect exposure and model exposure based on chemical production, use and fate. Outcomes will support evidence-based regulation and management of chemicals to minimise adverse impacts of chemical exposure in Australia.Read moreRead less
Understanding changes in chemical exposure through integrative sampling and systematic archiving. Poor data on exposure limits our understanding of the effects of chemical exposure on health. This project will aim to develop population-based exposure monitoring strategies to measure exposure, exposure trends, the success of intervention strategies and associations between exposure and health outcomes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100129
Funder
Australian Research Council
Funding Amount
$249,000.00
Summary
Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution ma ....Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution mass spectrometer is fundamental to extend our research capabilities to new environmental contaminants and environmental exposure biomarkers, as well as consumption biomarkers of new illicit drugs and their metabolites. This instrument will fill an important gap in our capacity to link health/ecological risk to unknown chemicals and will allow interdisciplinary researchers to advance work in environmental toxicology, chemistry and forensics.Read moreRead less