The Role Of The Novel Gene Herpud1 In Insulin Secretion In Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$502,370.00
Summary
A reduced ability to secrete insulin is the cause of high blood sugar in type 2 diabetes. This study has identified a gene called Herpud1 that affects insulin secretion. By studying the effects of this gene we are improving our knowledge of the defects that occur in Type 2 diabetes. This has the potential of providing better therapeutic strategies and identifying targets for the developments of better drug development.
Diabetic cardiomyopathy (DiabCM) is common in people with diabetes. It predisposes to heat failure. Its cause remains unclear and there is no specific treatment for DiabCM. Inflammation is a fundamental tissue response to a metabolic insult and it occur in DiabCM. The central hypothesis in this work is that inflammation through myocardial macrophage cells contributes to DiabCM. This hypothesis will be tested in animal models and also in cell culutre studies.
Prediction Of Adverse Outcomes Following A Fragility Fracture
Funder
National Health and Medical Research Council
Funding Amount
$148,426.00
Summary
Individuals with an existing fracture are at increased risk of adverse outcomes such as re-fracture and premature mortality, but it is not clear why. We propose to evaluate risk factors, and prognostic models, for predicting the risk of adverse outcomes. We also propose to develop a quantitative risk-benefit framework for evaluating the clinical utility of such prognostic models and help ensure that therapies appropriately address real-life experience of osteoporotic patients.