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RZR-alpha In The Control Of Proliferative Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$521,706.00
Summary
Four million Australians have cardiovascular disease accounting for 35% of all deaths. CVD is the most expensive disease burden and a National Health Priority. Smooth muscle cell growth is a cause of CVD. However, the mechanisms controlling SMC hyperplasia are poorly understood. This project will provide key insights on the role of RZR-alpha in the pathogenesis of blood vessel disease, and develop novel gene-targeting approaches for new opportunities to control complications of CVD.
Modelling Of Clinic And Ambulatory Blood Pressure On Cardiovascular Risk And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$133,957.00
Summary
Whilst ambulatory blood pressure monitoring data has been shown to be a good predictor of cardiovascular events, there remains controversy as to its utility in clinical practice. This project will use data from existing population and clinical cohort studies to examine the role of ambulatory blood pressure in risk assessment and hypertension management in Australia and around the globe. The findings are likely to have a major impact on clinical guidelines for hypertension management.
Cardiovascular disease is the biggest killer in Australia. It describes diseases of the heart and blood vessels including heart attack and stroke. The risk of developing these diseases is affected by our diet and lifestyle and also by our genetic makeup that we inherit. In this project we are aiming to identify the specific heritable genetic differences between individuals that put us at greater risk of cardiovascular disease. We are studying large families from the Busselton Health Study.
Developmental Origins Of Adult Cardiovascular Disease: Vascular Health In The Raine Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,087,427.00
Summary
The Raine study is a unique long term experiment that has collected extensive pre-birth and childhood data in ~3000 young Australians, who are now 27 years old. We plan to measure the artery health of 1200 of these volunteers and to determine what factors, both before and after birth, influence the presence of early atherosclerosis in humans. This study will guide strategies aimed at early prevention of heart attacks and stroke in humans, by defining the major risk factors.
Genetic And Early Life Predictors Of Ectopic Fat And Their Association With Cardiometabolic Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,706,136.00
Summary
Obesity in childhood predicts adult cardiovascular disease. Body mass index as a measure of obesity does not fully describe the biology of excess adiposity. However, differences in the distribution of body fat, particularly fat around organs, may explain some of the excess risk. We will examine effects of genetic, pregnancy and childhood factors on different body fats and cardiovascular risk in Raine Study participants at 26 years. These young adults have been studied from pregnancy to adulthood
Novel GPCR Transactivation Of Serine Kinases In Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$386,565.00
Summary
All of biology and disease is based on cells receiving signals from hormones and growth factors via cell surface receptors. Cells integrate these signals to give a response which may be cell growth or the secretion of further hormones and growth factors. Signals from receptors can intersect to modify the response. This project will explore a new interaction we have discovered where a hormone activates its receptor to cause the activation of a growth factor receptor potentially providing new drug ....All of biology and disease is based on cells receiving signals from hormones and growth factors via cell surface receptors. Cells integrate these signals to give a response which may be cell growth or the secretion of further hormones and growth factors. Signals from receptors can intersect to modify the response. This project will explore a new interaction we have discovered where a hormone activates its receptor to cause the activation of a growth factor receptor potentially providing new drug targets in cardiovascular disease.Read moreRead less
Preeclampsia (PE) is the most common serious medical disorder of human pregnancy and leads to life-threatening problems for both mother and baby. Currently, the only cure for PE is delivery of the baby, even if the baby is not ready for birth. My research focuses on understanding how PE develops. Understanding how PE develops will help us to treat this disease and thereby improve outcomes for mothers and babies.
Childhood Precursors Of Adult Cardiovascular Disease, Obesity And Diabetes- 16 Year Follow Up Of A Longitudinal Cohort
Funder
National Health and Medical Research Council
Funding Amount
$835,631.00
Summary
There is a world wide 'epidemic' of obesity and diabetes with rates tripling in young adults in the last twenty years. This is likely to lead to an upsurge in heart attack and stroke and to reverse many of the gains seen in this area in Australia. This project aims to study the childhood and antenatal precursors for the risk of adult obesity, diabetes, heart disease and stroke. The study involves The Perth longitudinal childrens 'Raine' cohort, a unique group of just under 3000 children, first m ....There is a world wide 'epidemic' of obesity and diabetes with rates tripling in young adults in the last twenty years. This is likely to lead to an upsurge in heart attack and stroke and to reverse many of the gains seen in this area in Australia. This project aims to study the childhood and antenatal precursors for the risk of adult obesity, diabetes, heart disease and stroke. The study involves The Perth longitudinal childrens 'Raine' cohort, a unique group of just under 3000 children, first monitored in the womb before mid pregnancy and then repeatedly through to the age of 13 years. Every 2 to 3 years the study children have been carefully assessed for changes in fatness, blood pressure and more recently, nutrition, physical activity and fitness, blood cholesterol and tendency to diabetes. Families have also been carefully monitored for a range of social characteristics and mental health. We already have evidence that about a fifth of the children at age 8 are particularly at risk of obesity, diabetes and cholesterol problems and high blood pressure. We now plan to study the children after puberty at age 16, when they will be adopting a range of more adult behaviours which may profoundly affect these risks. This study will provide comprehensive information on the children from before birth to adolescence and help pinpoint ways in which growth in the womb, and subsequent childhood behaviour interacts with influences of family, social factors, environment and mental health to affect long term risk of obesity, premature diabetes or heart disease. The study will also provide a basis for future examination of the links between genes, environment and health.Read moreRead less