Novel Morphological Retinal Vascular Features As Early Biomarkers Of Vision-threatening Eye Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$107,169.00
Summary
Vision loss is not just a personal health burden, but a huge socio-economical burden. Management of major vision-threatening eye diseases such as diabetic retinopathy, age-related macular degeneration and glaucoma will be improved if we can successfully identified persons at risk of developing the disease before clinical presentation to benefit from preventive treatment. My research aims to contribute to the prediction of these blinding diseases using advanced computer imaging analysis for simpl ....Vision loss is not just a personal health burden, but a huge socio-economical burden. Management of major vision-threatening eye diseases such as diabetic retinopathy, age-related macular degeneration and glaucoma will be improved if we can successfully identified persons at risk of developing the disease before clinical presentation to benefit from preventive treatment. My research aims to contribute to the prediction of these blinding diseases using advanced computer imaging analysis for simple retinal photographs.Read moreRead less
Using Pharmacogenetics To Personalize Treatment Outcome To Ranibizumab (Lucentis) For The Eye Disease Age-related Macular Degeneration (AMD)
Funder
National Health and Medical Research Council
Funding Amount
$623,891.00
Summary
The drug Lucentis has revolutionized the treatment of age-related macular degeneration, one of the commonest causes of severe vision loss in Australia. Unfortunately, up to 25% of patients continue to lose vision despite this treatment. We will use the latest gene chip technology to identify the genetic variant responsible for this poor response. Having this information will allow us to personalise treatment for the patient leading to improvement in their vision.
Predictors Of Treatment Outcomes Following Anti-vascular Endothelial Growth Factor (VEGF) Therapy For Neovascular AMD.
Funder
National Health and Medical Research Council
Funding Amount
$240,277.00
Summary
Age-related macular degeneration (AMD) is the most common cause of severe, irreversible loss of vision amongst elderly populations in the developed world. Bleeding in the retina destroys central vision. New treatments have been developed to stop this bleeding. However not all patients benefit equally, with some still losing vision. This project aims to investigate what determines how well an individual responds to treatment, in particular, how genes might influence the response.
I am an epidemiologist, primarily interested in the study and quantitative assessment of the environment-health relationship. Specifically, my current research focuses on development of innovative methods to assess the impact of ecosystem change (eg, clim
Identifying The Barriers To Optimal Diabetes And Diabetic Retinopathy Care In Non-English Speaking Adults With Type I And II Diabetes
Funder
National Health and Medical Research Council
Summary
Diabetes is a growing epidemic, with diabetic retinopathy being one of its common complications. With an ageing population, the public health and economic impact associated with diabetes are expected to magnify. Among the risk factors for sub-optimal diabetes care, language proficiency and cultural differences have been indicated. However, there is little to no research into the barriers of diabetes care in Australia�s non-English speaking population, which is the purpose of the proposed study.
An Investigation Into The Importance Of Potable Water As A Source Of Melioidosis In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$362,036.00
Summary
Melioidosis is a potentially fatal infection that occurs throughout the Top End. Infection usually sets in after exposure to contaminated soil or surface water. A recent outbreak of melioidosis in which three of seven cases died was traced to the community's drinking water supply. Subsequent improvements to the community's drinking water treatment appear to have brought the outbreak under control. However, the ability of the bacteria responsible for this infection to survive within the body for ....Melioidosis is a potentially fatal infection that occurs throughout the Top End. Infection usually sets in after exposure to contaminated soil or surface water. A recent outbreak of melioidosis in which three of seven cases died was traced to the community's drinking water supply. Subsequent improvements to the community's drinking water treatment appear to have brought the outbreak under control. However, the ability of the bacteria responsible for this infection to survive within the body for many years before causing late onset infection means that further cases may be recorded in the affected community for years to come. This project aims to assess whether the drinking water supply to other rural communities presents a risk of melioidosis throughout the Top End. Drinking water supplies will be tested for the presence of the bacteria that cause melioidosis. Genetic fingerprinting will be used to compare each strain isolated from water specimens with strains obtained from infections previously diagnosed in hospitals throughout the Top End. This will involve the combined efforts of researchers in Western Australia, the Northern Territory and Queensland. Comparison of these results with standard measures of drinking water quality will enable the research team to work out whether any routinely performed tests can be used as a guide to melioidosis risk. The team will also examine whether any geographical features such as deep water supply or the type of vegetation present can be used to assess melioidosis risk. A clearer picture of melioidosis risk will make it easier to target the delivery of preventive methods such as chlorination or alternatives to specific water supplies. Preliminary studies in Western Australia suggest that primary prevention of melioidosis may be possible. We need to see how widely those findings apply. It is hoped that this work will lead to a significant reduction in the risk of contracting this disease throughout the endemic region.Read moreRead less
Biomechanical And Physiological Responses Of Children And Young Adults To Different Computer Workstations
Funder
National Health and Medical Research Council
Funding Amount
$207,352.00
Summary
Computer use is increasing with 95% of Australian primary school children now using computers. Two out of three children and three out of four adult workers report pain associated with computer use. This has lead to concerns that increased computer use may be responsible for an increase in musculoskeletal disorders in young people. Little is known about the physical consequences of children's use of computers. The information we have on adult use is now out of date because of changes to computer ....Computer use is increasing with 95% of Australian primary school children now using computers. Two out of three children and three out of four adult workers report pain associated with computer use. This has lead to concerns that increased computer use may be responsible for an increase in musculoskeletal disorders in young people. Little is known about the physical consequences of children's use of computers. The information we have on adult use is now out of date because of changes to computer technology and how computers are used. It is therefore not possible to provide evidence-based recommendations for safe use of computers by young people. Critical gaps in our knowledge include the appropriate desk design and computer display position. The proposed studies will use recent advances in biomechanical and physiological measurement and modelling of musculoskeletal stress to evaluate a range of desk designs and computer display positions for young adults, preadolescentchilden and early school age children. The outcomes will include the first detailed description of the physical stresses of computer use by children and preliminary guidelines for workstation design.Read moreRead less
A Telephone And SMS Intervention To Promote Screening For Diabetic Retinopathy In People With Diabetes In Australia
Funder
National Health and Medical Research Council
Funding Amount
$28,796.00
Summary
One in two people with diabetes in Australia do not receive adequate screening or follow-up for diabetic retinopathy, a leading complication of diabetes and cause of vision loss and blindness. To tackle this issue, a new Australian study will evaluate a new telephone intervention designed to inform people with diabetes about diabetic retinopathy screening. This intervention is expected to improve future adherence to national screening guidelines for diabetic retinopathy.