The Cellular Organisation Of Interneurones In Human Retina
Funder
National Health and Medical Research Council
Funding Amount
$526,454.00
Summary
Our goal is to determine the numbers and types of nerve cells in the human retina: the part of the eye where visual processing starts. This data will serve as a baseline against which effects of visual disease can be measured.
Glial-neuronal-vascular Interactions In A Novel Transgenic Model Of Muller Cell Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$626,585.00
Summary
Muller cell disfunction is a feature shared by many retinal diseases. This project aims to study the contribution of Muller cell dysfunction to retinal neuronal damage and blood-retinal barrier breakdown in a novel transgenic model we recently generated. Results of this study will also be of interest to scientists and clinicians seeking to understand better and treat diseases of the central nervous system in general.
How Does Glucose Protect The Retina And Optic Nerve Against Ischaemia?
Funder
National Health and Medical Research Council
Funding Amount
$418,171.00
Summary
Raised blood sugar levels are generally considered to be bad for nerve cells, especially those in the eye. But we have made a groundbreaking discovery finding that in the short-term, sugar can rescue nerve cells in the eye from death caused by lack of blood flow. In this project we will investigate how this remarkable effect is achieved.
Novel Mechanisms Of Early Age Related Macular Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$933,953.00
Summary
Age Related Macular degeneration (AMD) is a leading cause of blindness in Australia. In this project we will examine a novel mechanism by which the cells at the back of the eye, called retinal pigment eptihelial cells contribute to vision loss early in the disease. In addition we will examine the potential for two currently used drugs as well as a novel laser treatment in slowing the progression of disease.
The Role Of Estrogen Signalling In The Development And Progress Of Neovascularisation In Macular Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Age-related macular degeneration is a common eye disease. In the advanced stages of the disease, abnormal and leaky blood vessels form, causing permanent and severe vision loss. A novel treatment is the application of the sex hormone, estrogen, which could halt abnormal blood vessel growth in the eye. This project aims to confirm the protective effects of estrogen on eye health and whether mutations in estrogen-related genes alter the risk of vision loss due to abnormal blood vessel growth.
Understanding the structure of the human retina is important for understanding normal visual function. The goal of this study is to supply data on the distribution, density and connectivity of nerve cells in the human retina. Our study will provide a foundation for areas of clinical investigation of the human retina.
Retinal Endothelial Cell Changes That Precede Retinal Vein Occlusion And The Retinal Extracellular Space Changes That Follow It
Funder
National Health and Medical Research Council
Funding Amount
$118,121.00
Summary
Dr. Min Hye Kang, at The University of Western Australia, is investigating microscopic blood vessel changes that precede the onset of devastating blindness. She is also studying functional changes that occur in the retina following deprivation of its blood supply. Her research has significantly improved our understanding of cellular mechanisms that lead to blindness. It has also aided in the development of new treatment strategies for the prevention of vision loss.
The Role Of Microglia In Early Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$665,582.00
Summary
Diabetic retinopathy is one of the most feared complications of diabetes. This project will examine the role that retinal immune cells called microglia have in causing early changes in the vasculature. We will examine whether diabetes changes the way neurons communicate with blood vessels, opening up a possible treatment target that could prevent the progression to more advanced disease.
Developing Personalised Treatment For Retinal Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$262,220.00
Summary
Dr Chen seeks a clinical CDF1 to support his ambition in combining his expertise in clinical management of retinal diseases with a growing track record of clinical trials and laboratory science to develop treatment for retinal degeneration. This is achieved through a patient-centred translational platform that he has established. In the next 5 years, He will identify the most suitable method for measuring progression and develop personalised therapy for a phase I clinical trial.
Advanced New Therapeutics And Diagnostics In Retinal Diseases And Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$3,550,944.00
Summary
This program proposal targets the most common blinding diseases in clinical ophthalmology. The applicant team includes research and clinical ophthalmologists and basic scientists. The team have an internationally established reputation in bringing basic science discoveries to the point where they can impact directly on clinical diagnosis and therapy. The proposed research includes new treatment therapies for diabetic retinopathy, age related macular degeneration, and retinal vascular diseases. A ....This program proposal targets the most common blinding diseases in clinical ophthalmology. The applicant team includes research and clinical ophthalmologists and basic scientists. The team have an internationally established reputation in bringing basic science discoveries to the point where they can impact directly on clinical diagnosis and therapy. The proposed research includes new treatment therapies for diabetic retinopathy, age related macular degeneration, and retinal vascular diseases. A new diagnostic technique for glaucoma and new instrumentation for detecting areas of poor blood flow and oxygen supply in the eye are also to be developed. Past successes in our current program grant make us confident that we can produce clinically useful outcomes from this new proposal.Read moreRead less