Pathways Of Neurosteroid-mediated Protection Following Compromised Pregnancy And Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$565,785.00
Summary
The hormonal environment of pregnancy is essential for normal development of the fetal brain. Levels of key hormones fall following premature birth and are further suppressed if the fetus is small or subjected to stress. This leads developmental problems in infants from the pregnancies. This project will examine effectiveness of replacement and supplementation treatments with critical neurosteroid hormones in reversing the adverse neurological effects of these complications of pregnancy.
The Nutritional Geometry Of Ageing In A Rodent Model
Funder
National Health and Medical Research Council
Funding Amount
$979,269.00
Summary
A central belief in ageing research is that eating fewer calories prolongs life, and that the source of calories (carbohydrate, fat or protein) is irrelevant. However, a critical assessment indicates that this conclusion is premature. We will use recent techniques in nutrition to define for the first time in mammals the relationship between diet and ageing in a normal and a prematurely ageing strain of mice. The project will provide a novel nutritional approach for promoting healthy ageing.
The Intrarenal Renin Angiotensin System (RAS) In Indigenous Women: An Early Indicator Of Renal Dysfunction In Women At Risk Of Pregnancy Complications
Funder
National Health and Medical Research Council
Funding Amount
$645,358.00
Summary
Indigenous women are twice as likely to have low birth weight babies compared to non-Indigenous women and 2.5 times as likely to develop preeclampsia, possibly because they have a much greater incidence of chronic kidney disease, predisposing them to these pregnancy outcomes. We have found a new, sensitive marker of early stage renal dysfunction in pregnancy that could be useful for detecting early stage renal disease and which is indicative of an increased risk of adverse pregnancy outcome.
Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suic ....Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suicide risk; use these systems to investigate how different situational factors interact with different combinations of service interventions to influence suicide risk; and share the findings to reduce railway suicide in Australia and overseas.Read moreRead less
Service Ecosystems Management for Collaborative Process Improvement. Australian government agencies currently explore opportunities for streamlining their business processes. A promising approach relates to the improvement of cross-agency processes based on service-enabled technologies. This project will use requirements within Queensland Government for the design of a service ecosystem and methodological and management concepts to derive a general framework for intra-organisational ecosystems. ....Service Ecosystems Management for Collaborative Process Improvement. Australian government agencies currently explore opportunities for streamlining their business processes. A promising approach relates to the improvement of cross-agency processes based on service-enabled technologies. This project will use requirements within Queensland Government for the design of a service ecosystem and methodological and management concepts to derive a general framework for intra-organisational ecosystems. Though the focus will be on government processes, the project will generalise beyond this scope for a wider uptake of service ecosystems in Australian organisations. This will lead to reduced process costs and risks and will leverage the exploration of new revenue streams, e.g. shared services and reward schemes.Read moreRead less
Intelligent Design Advisor for Manufacturing Process Knowledge within Concurrent Engineering in the Aerospace Industry. At present the design of engineering components in the aerospace industry is accomplished by experts from design and manufacturing either sequentially or in collaboration. If performed in sequence then time and quality is jeopardised. If performed in collaboration then more manpower than is necessary is expended. The aim of this project is to develop an intelligent design advis ....Intelligent Design Advisor for Manufacturing Process Knowledge within Concurrent Engineering in the Aerospace Industry. At present the design of engineering components in the aerospace industry is accomplished by experts from design and manufacturing either sequentially or in collaboration. If performed in sequence then time and quality is jeopardised. If performed in collaboration then more manpower than is necessary is expended. The aim of this project is to develop an intelligent design advisor for Manufacturing Process Knowledge that will provide this expert knowledge to the design engineer in order to speed up the design process while reducing costs and still maintaining the high standard of quality necessary in the Aerospace industry.Read moreRead less
Internet Timing for the Ages: Establishing the New Timekeeping System. All computers incorporate a software clock, essential to myriad software applications. An economic way to synchronize such clocks is over a network, however the approach the Internet currently depends upon is unreliable and vulnerable. This project aims to establish a new architecture for networked timekeeping, built on future-proofed fundamentals, that will for the first time address each of accuracy, reliability, and trust. ....Internet Timing for the Ages: Establishing the New Timekeeping System. All computers incorporate a software clock, essential to myriad software applications. An economic way to synchronize such clocks is over a network, however the approach the Internet currently depends upon is unreliable and vulnerable. This project aims to establish a new architecture for networked timekeeping, built on future-proofed fundamentals, that will for the first time address each of accuracy, reliability, and trust. The expected outcome is a national prototype, serving the public with accurate and trusted time, that will form the basis of the next generation timekeeping system for the Internet and the Internet of Things. Expected benefits include enhanced productivity across the digital economy, and resilience to GPS failures.Read moreRead less
Robust Control Design using Micro-Actuators. Recent advances in micro-actuators have enabled many new applications in complex systems. Examples include ultra-high density disk drives, low-cost vibration tables, and micro-robotic systems. However, control design for these systems is very challenging because the micro-actuators have severely limited dynamic ranges and strong couplings. The proposed project aims to study new control design approaches for these complex systems. The work will focus o ....Robust Control Design using Micro-Actuators. Recent advances in micro-actuators have enabled many new applications in complex systems. Examples include ultra-high density disk drives, low-cost vibration tables, and micro-robotic systems. However, control design for these systems is very challenging because the micro-actuators have severely limited dynamic ranges and strong couplings. The proposed project aims to study new control design approaches for these complex systems. The work will focus on both theoretical studies and experimental applications of such systems. The outcome of the project will help put Australia in a more advanced position in this niche area of leading age technology.Read moreRead less
Leveraging open innovation: software and processes for engaging with online communities. The research could help transform the ability of Australian industry to design software systems and processes that (i) engage with online communities to create and enhance organizational knowledge, (ii) accelerate innovation processes, and (iii) exploit existing intellectual property (IP).