Fetal Cardiovascular Development And The Impact Of Chronic Hypoxia And Fetal Growth Restriction
Funder
National Health and Medical Research Council
Funding Amount
$307,232.00
Summary
Low birth weight occurs in 7% of Australian babies and is associated with an increased risk of cardiovascular disease in adult life. Understanding the mechanisms underlying heart and blood vessel development in low birth weight babies will lead to improved identification and intervention in those individuals at risk of cardiovascular disease in adult life, improving heart health for Australians. Reducing cardiovascular disease will improve both quality and quantity of life for Australians.
The Early Origins Of Obsteric Diseases: Biological Investigations And Biomarker Discovery
Funder
National Health and Medical Research Council
Funding Amount
$282,290.00
Summary
Recent evidence has pointed to the beginning of pregnancy as the time when biological cascades begin that cause common diseases of pregnancy. This opens the door to developing bloods test in early pregnancy predicting who will develop problems, and to hunt for novel proteins in the bloodstream that are causing the illnesses. 'Proteomic technology' will be used, a new cutting edge tool that can scan the entire protein pool in mum's blood in a single experiment.
Developing Molecularly Targeted Therapeutics And Diagnostics For Pregnancy Complications
Funder
National Health and Medical Research Council
Funding Amount
$321,489.00
Summary
Pregnancy complications still causes the death of mothers, and their babies. During this fellowship, we will be developing new treatments and clinical tests for three important complications of pregnancy. We will run clinical trials of a new medication based treatment to cure ectopic pregnancies. We will also develop a blood test that can identify those babies still in the womb but suffering dangerously low oxygen levels. Lastly, we will develop drugs to treat preeclampsia, a serious condition o ....Pregnancy complications still causes the death of mothers, and their babies. During this fellowship, we will be developing new treatments and clinical tests for three important complications of pregnancy. We will run clinical trials of a new medication based treatment to cure ectopic pregnancies. We will also develop a blood test that can identify those babies still in the womb but suffering dangerously low oxygen levels. Lastly, we will develop drugs to treat preeclampsia, a serious condition of pregnancy.Read moreRead less
Indigenous Health Epidemiological Studies To Describe And Improve Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
Professor Eades is a leading Indigenous health researcher. Her research combines 1) studies that explore intergenerational and early life influences that increase the risk Indigenous people developing heart disease and type 2 diabetes; and 2) the conduct of randomised controlled trials to test the effectiveness of health care intervention in improving Indigenous health outcomes.
Strengthening Primary Health Care Systems For Under-served Populations Worldwide
Funder
National Health and Medical Research Council
Funding Amount
$476,728.00
Summary
The World Health Organization has identified the strengthening of primary health care systems as a priority area for global health. My research program focusses on identifying, developing and testing innovative strategies to improve access to high quality primary health care for under-served populations in Australia (particularly for Aboriginal and Torres Strait Islander communities), rural India, China and the USA.
Discovering The Genetic Causes Of Congenital Heart Disease Using Systems Biology
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Congenital heart disease (CHD) affects one in one hundred live-born babies, representing a significant health burden in Australia and worldwide. My research team is using state-of-the-art DNA sequencing technology to sequence the entire genome of hundreds of patients with CHD and their family members. My research program develops fast and reliable computer software to accelerate the discovery of the genetic causes of CHD, and make personalised genome-based medicine a reality.
Novel Health Data Systems For Translation And Impact
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Health research seeks to benefit society by improving health. However, there is a gap between the findings of research and healthcare practice. New systems are beginning to change the way research data are used to improve health outcomes. I am an HIV specialist developing and evaluating several new data systems and my vision for the next four years is to use these to improve the translation of health research into practice and policy for the benefit of people with HIV and society at large.
Exploring And Exploiting Novel Therapeutic Avenues In Mesothelioma
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Mesothelioma is a fatal cancer of the lungs. It rapidly grows and invades surrounding tissues such as the ribcage, causing severe shortness of breath and pain. Chemotherapy has limited effect and although immunotherapy appears promising, most patients do not respond. I will investigate why mesothelioma is so invasive; how to improve the response to immunotherapy and how to best combine chemotherapy and immunotherapy. I aim to develop new treatments that will benefit patients with mesothelioma.
Platform Nanotechnologies For Oral Delivery Of Drugs, Therapeutic Protein And Peptide Delivery
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
The development of reliable oral delivery systems for problem drugs and biologics is one of the biggest challenges faced by the pharmaceutical industry in recent times. In order to tackle these challenges, I have developed programmable nanoparticles capable of efficiently deliver wide range of drugs including large peptides and proteins orally.