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Genetic And Environmental Factors And Early Lung Problems Can Be Related To Allergy And Poor Lung Development In Preschool Age Children
Funder
National Health and Medical Research Council
Funding Amount
$122,032.00
Summary
This important new collaboration between the Murdoch ChildrenÍs Research Institute and Barwon Health explores the impact of early lung development on longer term respiratory health. It utilises a newly validated, accurate and safe technique to measure lung function in young babies and children. Data on environmental factors and lung function will help us explore the risk factors for the development of allergy, asthma and lung infections in early life.
Non-invasive Methods Of Measuring Work Of Breathing In Children
Funder
National Health and Medical Research Council
Funding Amount
$41,267.00
Summary
Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing ....Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing in children are managed world-wide.Read moreRead less
Chronic obstructive pulmonary disease (COPD) causes airway narrowing and lung destruction resulting in breathlessness and cough. Earlier detection of acute attacks of breathlessness may improve treatment, prevent progression and reduce risk of death. The forced oscillation technique can detect attacks earlier and is easy to perform. It will be used in this study for home monitoring with application of time series analyses to accurately detect change so that acute attacks can be treated earlier.
Early Origins Study Of Cystic Fibrosis-related Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$128,188.00
Summary
Cystic Fibrosis is a genetic condition that causes recurrent lung infections and early death. Some patients also develop diabetes which causes a more rapid decline. Many young children with CF have “pre-diabetes” but guidelines do not recommend screening high glucose in this group. In order to intervene early, this study aims to determine if “pre-diabetes” in very young children with Cystic Fibrosis causes poorer growth, lung function or an increase in bacterial infections to.
THE EFFECT OF LONG ACTING BRONCHODILATORS ON VENTILATION IN COPD
Funder
National Health and Medical Research Council
Funding Amount
$143,676.00
Summary
COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading ....COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading to more targeted therapeuticsRead moreRead less
Design And Implementation Of A Human Challenge Model For Neisseria Gonorrhoeae
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Gonorrhoea is a major public health problem that can lead to severe disease and promote the spread of HIV. Gonorrhoea infections are increasing worldwide and the spread of antibiotic resistant gonorrhoea is a critical health threat. This study aims to develop a controlled infection model for male throat and genital gonorrhoea infection in order to improve scientific understanding of gonorrhoea infection and responses to novel antibiotic treatment; and provide insights into vaccine development.
Reference Values For Spirometry, Lung Volumes, Diffusing Capacity, And Fractional Exhaled Nitric Oxide In First Nations Australians
Funder
National Health and Medical Research Council
Funding Amount
$83,832.00
Summary
Reference values in lung function tests allow respiratory doctors to accurately interpret results in order to effectively diagnose, treat and manage respiratory disease. Currently, reference values do not exist for First Nations adults. I will recruit 600 healthy First Nations adults from communities in Queensland and the Northern Territory for several lung function tests. Data collected will be submitted to the Global Lung Function Initiative to be incorporated into future guidelines.
Rapid Point-of-Care (POC) Tests For Sexually Transmitted Infections (STIs): Evaluation Of Accuracy, Acceptability And Impact In Australia And Papua New Guinea (PNG)
Funder
National Health and Medical Research Council
Funding Amount
$99,883.00
Summary
This research, composed of three studies, aims to evaluate rapid point-of-care tests for selected sexually transmitted infections (including syphilis, Chlamydia and gonorrhoea) to determine their accuracy and acceptability, their potential role in and impact on control of STIs in Papua New Guinea and remote settings in Australia.
Sleep, Telomere Length And Cardiorespiratory Phenotype In 11-12 Year Old Children: Cross-sectional Australian National Population Based Study
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
Telomeres are special areas at the ends of our chromosomes that ‘protect’ our DNA as our body cells divide. With ageing, our telomeres slowly become shorter, but the rate at which this happens varies. My project will investigate the associations between poor sleep duration and quality, increased risk of cardiovascular diseases, poor respiratory health and increased vulnerability to viral infections to shorter telomere length.
Exploring HIV Sexual Risk Behaviours Among ‘hidden’ MSM In Myanmar And Opportunities To Improve Health Through Information Communication Technology (ICT) Platforms
Funder
National Health and Medical Research Council
Funding Amount
$92,364.00
Summary
This research will describe sexual risk behaviours and perceptions of HIV vulnerability among 'hidden' MSM in Myanmar. It will characterise their sexual and social networks with both male and female partners, as well as identify barriers to accessing sexual health and HIV testing and support services. This study will also assess the potential for digital technology to deliver sexual health promotion and facilitate service access among hidden MSM in Myanmar.