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The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler. This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum ....The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler. This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum performance, delivering typically less than 20% of the loaded dose to the target site, the lungs. The new fundamental knowledge resulting from this research will enable the engineering of a high-efficiency groundbreaking DPI, with the potential to be fully adaptive user-specific benefiting millions of Australians. Read moreRead less
Enabling precise droplet control in hydrofluorocarbon free sprays. This project aims to investigate the use of blended propellants to replace hydrofluorocarbons in technical aerosols. This project expects to generate new knowledge in the area of multiphase fluid mechanics and aerosol science through a combination of modeling, optical and synchrotron X-ray measurement techniques. Expected outcomes of this project include a capacity to develop environmentally friendly technical aerosol formulation ....Enabling precise droplet control in hydrofluorocarbon free sprays. This project aims to investigate the use of blended propellants to replace hydrofluorocarbons in technical aerosols. This project expects to generate new knowledge in the area of multiphase fluid mechanics and aerosol science through a combination of modeling, optical and synchrotron X-ray measurement techniques. Expected outcomes of this project include a capacity to develop environmentally friendly technical aerosol formulations which can match and potentially outperform currently available hydrofluorocarbon based products. This should provide significant benefits to the pharmaceutical industry through the generation of new knowledge regarding the fundamental physics of multicomponent sprays.Read moreRead less
Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will ena ....Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will enable science-based guidelines, advancing disease control, local eradication, and regulatory approval for wombats. Our research framework is adaptable to other mange-impacted species, and advance methods and theory for control of treatable disease in wildlife.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100014
Funder
Australian Research Council
Funding Amount
$4,996,503.00
Summary
ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resist ....ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resistance and how the production environment interfaces with the bacterial microbiome, pathogens and water quality to cause disease. Outcomes will lead to increased productivity, international competitiveness, and lowered disease risk and significantly expand Australia's capacity in the aquaculture sector.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100022
Funder
Australian Research Council
Funding Amount
$4,787,259.00
Summary
ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop pr ....ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop protection. An expert multidisciplinary team uniting science, commercial and social licence pathways ensures industry and consumer uptake advancing $60B Australian Agriculture. The Hub translates to increased productivity, market access and enhanced environmental credentials of Australian food.
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New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based intervent ....New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based interventions and vaccines that protect the gut and lung from infectious and inflammatory issues. The harnessing of effective immune responses to control such challenges, are of enormous fundamental and long-standing biological interest, and are amongst the most important areas of current scientific research.Read moreRead less
Personalised Learning for Per-pixel Prediction Tasks in Image Analysis. AI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored ....Personalised Learning for Per-pixel Prediction Tasks in Image Analysis. AI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored to individual characteristics. The success of this project could significantly advance the fundamental research in image analysis. Expected outcomes include new knowledge and algorithms for image analysis, which could benefit fields like biology and archaeology, where labeled images are hard to attain and scarce.Read moreRead less
Real-time phylogenetics for food-borne outbreak surveillance. The project aims to introduce, for the first time, real-time evolutionary analysis of agricultural pathogens so that outbreaks affecting crops and the food supply can be managed precisely and rapidly. An expert team will implement a large-scale data analytics framework in user-friendly software that integrates Australian infectious disease genomics data with global data. Underpinning this work are new theory and algorithms that apply ....Real-time phylogenetics for food-borne outbreak surveillance. The project aims to introduce, for the first time, real-time evolutionary analysis of agricultural pathogens so that outbreaks affecting crops and the food supply can be managed precisely and rapidly. An expert team will implement a large-scale data analytics framework in user-friendly software that integrates Australian infectious disease genomics data with global data. Underpinning this work are new theory and algorithms that apply Sequential Monte Carlo to update phylogenetic analyses continuously as new data arrives. Expected outcomes include new knowledge of statistical algorithms for evolutionary analysis, relevant to biological disciplines beyond infectious disease; and enhanced capacity for infectious disease analysis. Read moreRead less
Increasing amphibian immunity to combat disease causing mass extinction. This project aims to increase amphibian survival to combat the devastating chytrid fungus by identifying resistance genes and increasing their frequency in the host population. The project is interdisciplinary and uses targeted genetic manipulation techniques developed for agriculture to improve disease resistance in wildlife for the first time. Expected outcomes include 1) enhanced international collaborations in comparati ....Increasing amphibian immunity to combat disease causing mass extinction. This project aims to increase amphibian survival to combat the devastating chytrid fungus by identifying resistance genes and increasing their frequency in the host population. The project is interdisciplinary and uses targeted genetic manipulation techniques developed for agriculture to improve disease resistance in wildlife for the first time. Expected outcomes include 1) enhanced international collaborations in comparative immunology, 2) a comprehensive understanding of immunity to chytridiomycosis, and 3) disease resistant amphibians. The anticipated benefit is ability to apply the optimal method to improve conservation of wildlife threatened by emerging disease, such as marker assisted selective breeding or genetic engineering.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100025
Funder
Australian Research Council
Funding Amount
$747,126.00
Summary
Using the blackleg fungus as a model for maximising fungicide efficacy. Resistance to chemicals impacts the ability to control many diseases across many crops. This project aims to identify key epidemiological factors contributing to fungicide resistance in an emerging model system, blackleg disease of canola, using innovative approaches. The outcomes of this research will be management strategies for minimising the risk of evolution of fungicide resistance, a key industry need. This will also e ....Using the blackleg fungus as a model for maximising fungicide efficacy. Resistance to chemicals impacts the ability to control many diseases across many crops. This project aims to identify key epidemiological factors contributing to fungicide resistance in an emerging model system, blackleg disease of canola, using innovative approaches. The outcomes of this research will be management strategies for minimising the risk of evolution of fungicide resistance, a key industry need. This will also enhance interdisciplinary collaborations through combining field and molecular research. These management strategies will provide significant economic benefits by ensuring increased canola yields, whilst providing health and environmental benefits through minimisation of unnecessary use of fungicides.Read moreRead less