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Australian Laureate Fellowships - Grant ID: FL230100030
Funder
Australian Research Council
Funding Amount
$3,320,000.00
Summary
A walk on the wild side: understanding disease resistance across plants. Plants are in constant battle with pests and pathogens. Wild species host genetic diversity, providing sources of disease resistance, while the narrow genetic base of crop varieties leads to an increasing reliance on the unsustainable application of chemical fungicides. Here I will apply the latest genomics approaches to characterise disease resistance gene diversity across the plant kingdom. Comparison of gene diversity wi ....A walk on the wild side: understanding disease resistance across plants. Plants are in constant battle with pests and pathogens. Wild species host genetic diversity, providing sources of disease resistance, while the narrow genetic base of crop varieties leads to an increasing reliance on the unsustainable application of chemical fungicides. Here I will apply the latest genomics approaches to characterise disease resistance gene diversity across the plant kingdom. Comparison of gene diversity within and between plant families will improve our understanding of resistance gene evolution in wild species and the impact of domestication and breeding on resistance gene diversity. Translation of this knowledge will support breeding for crop resilience, leading to durable resistance and more sustainable crop productionRead moreRead less
Rapid mapping of genes for complex traits. This project will develop a new resource that will allow rapid identification of genes controlling complex traits. This world-leading resource will improve knowledge of diseases like diabetes and neurological diseases.
Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
Special Research Initiatives - Grant ID: SR0354908
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outco ....The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outcomes and solutions to problems in agriculture, horticulture, forestry and protection of Australia's native flora. Researchers are struggling to create these links, constrained by disciplinary boundaries and geographical isolation. Key industries and researchers already support this proposal.Read moreRead less
Deciphering the regulation and function of the epigenome in eukaryotic development and stress response. The epigenome is an additional regulatory code superimposed upon plant and animal genomes that controls how they operate. This project will aim to understand the information encoded in the epigenome and how it changes in development and environmental stress, enabling manipulation of its function in crops and correction of its dysfunction in disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100116
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Western Australian Zebrafish Facility. Zebrafish facility: The zebrafish as a model vertebrate organism is fast approaching the importance of the laboratory mouse. This facility will enable the research community to fully embrace the zebrafish as a powerful research tool.
Defining the Brassica pan-genome and establishing methods for gene conversion based crop improvement. Gene content varies between individual varieties. The project aims to apply novel genomic tools to identify and characterise the fixed and variable gene content in the important crop canola and use this to understand genome evolution as well as develop tools to accelerate canola breeding. The project team have developed and used a high-resolution genotyping approach to demonstrate that gene conv ....Defining the Brassica pan-genome and establishing methods for gene conversion based crop improvement. Gene content varies between individual varieties. The project aims to apply novel genomic tools to identify and characterise the fixed and variable gene content in the important crop canola and use this to understand genome evolution as well as develop tools to accelerate canola breeding. The project team have developed and used a high-resolution genotyping approach to demonstrate that gene conversions, short recombination events which lead to the non-reciprocal exchange of genomic regions during meiosis, are abundant in crop genomes. The project aims to develop methods and resources to characterise gene conversion in canola and establish a basis for gene conversion based crop improvement.Read moreRead less
Developmental regulation of plant mitochondrial genome structure and copy number. Recombination is a major driving force behind mitochondrial DNA evolution and is responsible for the occurrence of cytoplasmic male sterile plants that are used by plant breeders to obtain high yield hybrids. A better understanding of the mechanisms that underlie mitochondrial and chloroplast genome maintenance and segregation will be a major fundamental scientific advance that will permit an integrated picture of ....Developmental regulation of plant mitochondrial genome structure and copy number. Recombination is a major driving force behind mitochondrial DNA evolution and is responsible for the occurrence of cytoplasmic male sterile plants that are used by plant breeders to obtain high yield hybrids. A better understanding of the mechanisms that underlie mitochondrial and chloroplast genome maintenance and segregation will be a major fundamental scientific advance that will permit an integrated picture of the interactions between the three plant genomes (nuclear, mitochondrial and chloroplastic). It is also a pre-requisite for the future manipulation of the cytoplasmic genomes leading to new ways to develop varieties with modified cytoplasms.Read moreRead less
Unique epigenetic states in plant stem cell niches for safeguarding genome integrity. Plant stem cells are the foundation cells of all plant growth and development, including generation of the reproductive cells. Therefore, it is critical that stem cells defend against attacks that may damage the genome. A unique epigenetic state in plant stem cell niches has been discovered that may protect the genome from damage due to parasitic DNA elements. Using sophisticated genomics, genetics, and cellula ....Unique epigenetic states in plant stem cell niches for safeguarding genome integrity. Plant stem cells are the foundation cells of all plant growth and development, including generation of the reproductive cells. Therefore, it is critical that stem cells defend against attacks that may damage the genome. A unique epigenetic state in plant stem cell niches has been discovered that may protect the genome from damage due to parasitic DNA elements. Using sophisticated genomics, genetics, and cellular technologies, this project will investigate how stem cell epigenetic state is linked to genome defence, how environmental stresses can disrupt the defence system, and the role of the system in driving new genetic diversity. This knowledge is of high importance as agricultural crops enter an era of increasingly challenging conditions.Read moreRead less
The chemical, molecular and evolutionary basis of key pollination transitions in Australian orchids and their conservation consequences. Many of Australia's unique orchids may face increased extinction risk in human modified landscapes because of their dependence on specific pollinators. This project will investigate the basis of transitions between key pollination strategies in orchids with the outcomes informing both evolutionary theory and future conservation programs.