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Modelling and Measurement of Flow-Structure Dynamics in the Human Upper Airway. Sleep disruption due to the common and disabling conditions of snoring and obstruction of the human upper airway can result in chronic fatigue, lost work and accidents caused by daytime drowsiness. To date the behaviour of the upper airway has not been adequately studied in terms able to reveal the mechanical causes of these conditions. This deficiency is addressed through the development and use of simulation tools ....Modelling and Measurement of Flow-Structure Dynamics in the Human Upper Airway. Sleep disruption due to the common and disabling conditions of snoring and obstruction of the human upper airway can result in chronic fatigue, lost work and accidents caused by daytime drowsiness. To date the behaviour of the upper airway has not been adequately studied in terms able to reveal the mechanical causes of these conditions. This deficiency is addressed through the development and use of simulation tools and measurement techniques that will elucidate the flow-structure dynamics leading to new diagnostic and improved treatment methods. Simulating the effect of treatment on any individual will permit it to be chosen to maximise its efficacy for a problem that costs the nation an estimated $2 Billion per year in lost productivity.Read moreRead less
Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease. Rhinovirus (RV) infections account for around 90 per cent of asthma exacerbations, yet the mechanisms behind this are unknown. This project will use mouse models to study the effects of early life RV infection and allergic sensitisation on respiratory and immunological development, with the expectation that early life RV infection disrupts anitgen presenting cell function.
Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity ....Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity in adult life. We expect to identify levels of IAP that will represent a health risk as well as the factors that may contribute to increased IAP in homes.Read moreRead less
Materials World Network for the Study of Macromolecular Ferrofluids. This work will develop an understanding that will allow us to optimise the properties of ferrofluids (magnetic liquids) to suit particular applications. Although the primary application that will be investigated is the treatment of retinal detachment, the results will be applicable to a wide range of applications including ferrofluid-based actuators, electromagnetic micropumps and fluid based valves and sealing systems. During ....Materials World Network for the Study of Macromolecular Ferrofluids. This work will develop an understanding that will allow us to optimise the properties of ferrofluids (magnetic liquids) to suit particular applications. Although the primary application that will be investigated is the treatment of retinal detachment, the results will be applicable to a wide range of applications including ferrofluid-based actuators, electromagnetic micropumps and fluid based valves and sealing systems. During the course of this work, young Australian scientists will be trained in a cross-disciplinary environment in a variety of aspects of both nano- and bio- technology that are a key part of the National Research Priority: Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
The Biology, Ecology, Pathology and Control of Mycosphaerella Leaf Blights in Australian Eucalypt Plantations. Leaf spot diseases, caused by Mycosphaerella, have become widespread in over 150,000 ha of Eucalyptus globulus (blue gum) plantations in Western Australia, causing severe reduction in canopy area of young trees. This project will research the epidemiology of these diseases by studying the life cycles of the key pathogenic Mycosphaerella species identified in a previous project, modes an ....The Biology, Ecology, Pathology and Control of Mycosphaerella Leaf Blights in Australian Eucalypt Plantations. Leaf spot diseases, caused by Mycosphaerella, have become widespread in over 150,000 ha of Eucalyptus globulus (blue gum) plantations in Western Australia, causing severe reduction in canopy area of young trees. This project will research the epidemiology of these diseases by studying the life cycles of the key pathogenic Mycosphaerella species identified in a previous project, modes and timing of spore dispersal, the infection process, and host specificity. The economic impact of leaf spot diseases will be assessed from large exclusion trials. A predictive integrated management package for Mycosphaerella foliar diseases will be formulated and evaluated to minimising disease impact.Read moreRead less
The cause of basal stem rot in second rotation Eucalyptus globulus plantations. The Eucalyptus globulus plantation industry consists of over 300000 ha in Australia and is worth 1 billion dollars. The industry has expanded rapidly since the mid 1980's and now many crops are in their second rotation. Recently, poor coppice growth in second rotation crops as a result of fungal basal rot or decay, has started to become a significant management problem to the industry. This project will determine th ....The cause of basal stem rot in second rotation Eucalyptus globulus plantations. The Eucalyptus globulus plantation industry consists of over 300000 ha in Australia and is worth 1 billion dollars. The industry has expanded rapidly since the mid 1980's and now many crops are in their second rotation. Recently, poor coppice growth in second rotation crops as a result of fungal basal rot or decay, has started to become a significant management problem to the industry. This project will determine the cause(s) of basal stem rot/decay and develop management strategies to reduce the impact of the problem.Read moreRead less
Pathogenicity of Mycosphaerella on Eucalyptus globulus plantations in Western Australia. Eucalyptus globulus is the main hardwood species grown in plantations in Western Australia. In recent years, the incidence of foliar damage caused by leaf spot fungi in the genus Mycosphaerella has started to become a worrying management problem for the industry. There are approximately 12 Mycosphaerella species associated with Eucalyptus globulus in Western Australia. This project will determine which are t ....Pathogenicity of Mycosphaerella on Eucalyptus globulus plantations in Western Australia. Eucalyptus globulus is the main hardwood species grown in plantations in Western Australia. In recent years, the incidence of foliar damage caused by leaf spot fungi in the genus Mycosphaerella has started to become a worrying management problem for the industry. There are approximately 12 Mycosphaerella species associated with Eucalyptus globulus in Western Australia. This project will determine which are the priority destructive Mycosphaerella species. The information gained will allow researchers to select and breed eucalypts for resistance of target Mycosphaerella species in the future. The project will also develop methods for rapid pathogenicity screening.Read moreRead less
A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conduct ....A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conductance properties of the channel. Accurately
determining these relationships provides a pathway to developing cures
for many neurological, cardiac, and muscular diseases.
Read moreRead less
Impact of shear stress on vascular adaptations in humans. Large arteries are important for the delivery of blood and oxygen to organs such as the heart and brain. A primary physiological stimulus which controls the size and function of these crucial arteries is the magnitude of flow or, more accurately, shear force that the inner wall of the artery is exposed to. We have developed novel software which enables non-invasive assessment of arterial wall velocity, diameter and blood flow. We will ass ....Impact of shear stress on vascular adaptations in humans. Large arteries are important for the delivery of blood and oxygen to organs such as the heart and brain. A primary physiological stimulus which controls the size and function of these crucial arteries is the magnitude of flow or, more accurately, shear force that the inner wall of the artery is exposed to. We have developed novel software which enables non-invasive assessment of arterial wall velocity, diameter and blood flow. We will assess the impact of acute and chronic changes in wall flow and shear on arterial size and function. We will also develop new software which measures other aspects of artery wall behaviour. These basic human physiology studies have direct implications for assessment of artery health in humans.Read moreRead less
Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if ....Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if the Cryptosporidium in humans is the same as that derived from water contamination sources (animals, sewage etc). The outcomes of this project will result in the development of more targeted, cost-effective preventive measures to minimize exposures to infections, accurate risk assessment, and scientific management of the watershed.Read moreRead less