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Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology ....Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology. This work could yield economic benefits in the long-term through patentable outcomes and will benefit the community by producing high impact research papers, providing training to Australians and forging links with renowned international scientists.Read moreRead less
Quantum Information and Entanglement: a new framework for Science and Technology with quantum many-body systems. The expected outcome of the research program is a significant boost in the understanding of quantum many-body systems, which will reinforce Australia's competitiveness and international profile in aspects of breakthrough science and frontier technologies. By developing both the underpinning theory and innovative computational tools, and by applying them to problems of recognised impor ....Quantum Information and Entanglement: a new framework for Science and Technology with quantum many-body systems. The expected outcome of the research program is a significant boost in the understanding of quantum many-body systems, which will reinforce Australia's competitiveness and international profile in aspects of breakthrough science and frontier technologies. By developing both the underpinning theory and innovative computational tools, and by applying them to problems of recognised importance, this program will have direct implications in areas of condensed matter physics, quantum statistical mechanics, particle physics, complex systems, quantum information science and technology, quantum computation, engineered quantum systems and nanotechnology. Read moreRead less
Novel approaches to strongly correlated quantum systems in two dimensions. The expected outcome of the research program is a significant boost in our understanding of strongly correlated quantum systems, which will reinforce Australia's competitiveness and international profile in aspects of breakthrough science and frontier technologies. By strengthening both the underpinning theory and innovative computational tools to study quantum many-body systems, and by applying them to specific problems ....Novel approaches to strongly correlated quantum systems in two dimensions. The expected outcome of the research program is a significant boost in our understanding of strongly correlated quantum systems, which will reinforce Australia's competitiveness and international profile in aspects of breakthrough science and frontier technologies. By strengthening both the underpinning theory and innovative computational tools to study quantum many-body systems, and by applying them to specific problems of recognized importance, this program will have direct implications in condensed matter physics and will exert significant influence in areas such as quantum chemistry, high energy physics, quantum computing, quantum atom optics and nanotechnology.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Colour vision and photoreceptors in reef fish: a model system to discover the function of double cones. Humans are visual animals and as lucky Australians we love to look at The Great Barrier Reef. This project, while rooted in the complexities of visual neurobiology, uses a recently discovered set of 4 different reef fish from the GBR to teach us more about fundamental principles in vision. These fish, diverse as damselfish and snappers, will help solve a mystery centuries old. Double cones are ....Colour vision and photoreceptors in reef fish: a model system to discover the function of double cones. Humans are visual animals and as lucky Australians we love to look at The Great Barrier Reef. This project, while rooted in the complexities of visual neurobiology, uses a recently discovered set of 4 different reef fish from the GBR to teach us more about fundamental principles in vision. These fish, diverse as damselfish and snappers, will help solve a mystery centuries old. Double cones are the commonest daytime photoreceptor in the eyes of almost all vertebrates (humans without them are exceptions) and yet nobody knows what they do. Reef fish have them, so let's ask them what they see!Read moreRead less
HIDE AND SPEAK - COLOUR COMMUNICATION IN REEF FISH. Fish play an important role in many Australian's lives, they are a source of recreation for scuba divers, snorkelers and fishermen, they are a draw card for tourists as well as a healthy source of food. This project will investigate the visual world of fish, unravelling their use of colour communication, thereby identifying environmental factors affecting successful communication. Such a study will provide insight into the impact on reef fish o ....HIDE AND SPEAK - COLOUR COMMUNICATION IN REEF FISH. Fish play an important role in many Australian's lives, they are a source of recreation for scuba divers, snorkelers and fishermen, they are a draw card for tourists as well as a healthy source of food. This project will investigate the visual world of fish, unravelling their use of colour communication, thereby identifying environmental factors affecting successful communication. Such a study will provide insight into the impact on reef fish of changes in water quality (e.g. river runoff) and temperature (e.g. bleaching events), as well as factors that affect the successful rearing of fish in aquaculture.
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Evaluating the role of buffer strips in reducing soil erosion and sediment delivery to water bodies. The role of vegetative buffer strips in reducing soil erosion and sediment delivery to water bodies is well established, but the physical processes and their interactions involved are not well understood. These hydraulic, sediment/chemical transport processes will be modelled from physical principles, recognising that the multi-size characteristics of soil plays a vital role in buffer strip effec ....Evaluating the role of buffer strips in reducing soil erosion and sediment delivery to water bodies. The role of vegetative buffer strips in reducing soil erosion and sediment delivery to water bodies is well established, but the physical processes and their interactions involved are not well understood. These hydraulic, sediment/chemical transport processes will be modelled from physical principles, recognising that the multi-size characteristics of soil plays a vital role in buffer strip effectiveness. This model will be validated using new and existing data sources, including both controlled experiments and field data obtained in Australia and overseas. A user friendly version of the model will be developed for farm managers and advisory services as a design tool.Read moreRead less
The improvement of climate change investigations by developing and applying innovative evolutionary subset time series modelling using semi-parametric sparse-patterned approaches. With an estimated US$6.98 trillion loss indicated in the Stern review, severe climate change will make world climate conditions harsher and more likely include large natural climate disasters. The health of the Australian economy is critically dependent on decisions of environmental managers. However, most problems of ....The improvement of climate change investigations by developing and applying innovative evolutionary subset time series modelling using semi-parametric sparse-patterned approaches. With an estimated US$6.98 trillion loss indicated in the Stern review, severe climate change will make world climate conditions harsher and more likely include large natural climate disasters. The health of the Australian economy is critically dependent on decisions of environmental managers. However, most problems of complexity arising in climate change involve issues on which we do not possess a deep understanding. This project draws upon a set of inter-disciplinary concepts and models centred in neural networks that enable us to advance our understanding of complexity, leading to superior quantitative tools and models to allow for improved environmental decision-making.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347955
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first ....A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first cell-sorting facility dedicated to the production of nerve cells suitable for molecular characterization and screening, providing the basis for identifying key molecules regulating brain function, ageing and repair of great importance to the biotechnology/pharmaceutical industry.Read moreRead less
Novel approaches for structural and functional analysis of the protein complex COG, a tether that controls intra-Golgi trafficking. Production and engineering of proteins are key methodologies of the life sciences in general and biotechnology in particular. Our ability to produce and analyse protein-based components of the cell determines the expense and speed of discovery, as well as the creation of new vaccines, drugs, and diagnostic methods. The current project aims to develop new approaches ....Novel approaches for structural and functional analysis of the protein complex COG, a tether that controls intra-Golgi trafficking. Production and engineering of proteins are key methodologies of the life sciences in general and biotechnology in particular. Our ability to produce and analyse protein-based components of the cell determines the expense and speed of discovery, as well as the creation of new vaccines, drugs, and diagnostic methods. The current project aims to develop new approaches for protein production and to apply them to the analysis of the basic mechanisms of cell self-maintenance.Read moreRead less