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Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The ....Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The outcomes will lead to the commercialisation by Australian breeding companies of barley varieties with durable fungal resistance. This will benefit the Australian economy by providing sustainability and protection for barley breeding thereby significantly reducing crop losses for this important global agricultural commodity.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100022
Funder
Australian Research Council
Funding Amount
$4,787,259.00
Summary
ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop pr ....ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop protection. An expert multidisciplinary team uniting science, commercial and social licence pathways ensures industry and consumer uptake advancing $60B Australian Agriculture. The Hub translates to increased productivity, market access and enhanced environmental credentials of Australian food.
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Understanding mosquito smell system: a new frontier in mosquito control. This project aims to identify and functionally investigate mosquito smell receptors, which are critical in detecting volatile compounds and locating their hosts from a considerable distance away. Mosquitoes display preferences for certain hosts over others, primarily determined by volatile chemicals produced by hosts. This study builds on recently discovered, novel, host-derived volatile compounds, which can elicit robust r ....Understanding mosquito smell system: a new frontier in mosquito control. This project aims to identify and functionally investigate mosquito smell receptors, which are critical in detecting volatile compounds and locating their hosts from a considerable distance away. Mosquitoes display preferences for certain hosts over others, primarily determined by volatile chemicals produced by hosts. This study builds on recently discovered, novel, host-derived volatile compounds, which can elicit robust responses and attractiveness from mosquitoes. Expected outcomes of the project are enhanced understanding of mosquito smell system and behaviours. This could provide significant benefits to how we can fight mosquitoes and mosquito-transmitted diseases in a more efficient and environmentally responsible way.Read moreRead less
Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for ....Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100027
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Plant Biosecurity. The ARC Training Centre in Plant Biosecurity aims to deliver a solution for Australia’s increasing biosecurity risk through generational change in its workforce coupled with breakthrough technologies. It will launch an innovative training program for future leaders who will build relationships with end users and engage meaningfully with communities for effective implementation strategies. Expected outcomes include a cohort of highly skilled graduates tha ....ARC Training Centre in Plant Biosecurity. The ARC Training Centre in Plant Biosecurity aims to deliver a solution for Australia’s increasing biosecurity risk through generational change in its workforce coupled with breakthrough technologies. It will launch an innovative training program for future leaders who will build relationships with end users and engage meaningfully with communities for effective implementation strategies. Expected outcomes include a cohort of highly skilled graduates that will innovate novel diagnostic technologies, enable data-driven decision platforms and address barriers to biosecurity adoption. This suite of graduates and technologies will transform the plant biosecurity sector to protect Australia’s $5.7 trillion natural and productive ecosystems.Read moreRead less
ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the d ....ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the design of peptides and proteins for targeted scientific, agricultural, biotechnology, animal health and pharmaceutical applications. CIPPS will assemble leading researchers from diverse disciplines to create a sustainable national entity that will drive new Australian industries and train next generation researchers.Read moreRead less
Utilising artificial intelligence to elucidate the physics of galaxies. For decades astronomers have puzzled over the connection between the structure and evolution of galaxies and the role played by host environments. This project aims to resolve this problem by combining multi-wavelength observations, multi-component simulations, and pioneering data analysis using artificial intelligence. In particular, we target the nearby Fornax galaxy cluster as a laboratory for studying galaxy formation in ....Utilising artificial intelligence to elucidate the physics of galaxies. For decades astronomers have puzzled over the connection between the structure and evolution of galaxies and the role played by host environments. This project aims to resolve this problem by combining multi-wavelength observations, multi-component simulations, and pioneering data analysis using artificial intelligence. In particular, we target the nearby Fornax galaxy cluster as a laboratory for studying galaxy formation in dense environments. Using our novel machine learning techniques, we will elucidate the physical mechanisms that drive the rapid evolution of star formation, galactic nuclei, and gas and dust content within Fornax. Our predictions will benefit ongoing and future surveys at the national and international level. Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH220100017
Funder
Australian Research Council
Funding Amount
$4,808,669.00
Summary
ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The progra ....ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The program addresses industry-led challenges for translation of biologics as molecular radiopharmaceuticals, building capacity in biomanufacturing, radiobiology and radiochemistry. The program establishes a dedicated manufacturing pipeline, future-proofing production and securing supply chain of next generation medical technologies.Read moreRead less
ARC Centre of Excellence for Gravitational Wave Discovery. ARC Centre of Excellence for Gravitational Wave Discovery. The mission of our Centre is to use gravitational waves to investigate the fundamental nature of relativistic gravity, ultra-dense matter, and cosmology. This will generate critical discoveries that cement Australia's leadership role in the gravitational wave mega-science instruments of the 2030s and 2040s. By bringing together a world-class team with broad and complementary expe ....ARC Centre of Excellence for Gravitational Wave Discovery. ARC Centre of Excellence for Gravitational Wave Discovery. The mission of our Centre is to use gravitational waves to investigate the fundamental nature of relativistic gravity, ultra-dense matter, and cosmology. This will generate critical discoveries that cement Australia's leadership role in the gravitational wave mega-science instruments of the 2030s and 2040s. By bringing together a world-class team with broad and complementary expertise we will develop core technologies for future detectors, discover new sources of gravitational waves, probe fundamental physics, and lay the foundations for an Australian gravitational wave observatory. Our discoveries will inspire Australia's youth to pursue high tech careers and position our staff and students to become leaders in both industry and academia.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less