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Investigations into and development of an intelligent decision support system for general practitioners in home-based sleep disorder diagnosis. Sleep disorders cost the Australian health system an estimated $40 million per year. General practitioner's surgeries are not well equipped to deal with diagnosis and the majority of the referrals to specialists are unnecessary. This research will investigate and develop an intelligent decision support system to provide a cost effective solution to thi ....Investigations into and development of an intelligent decision support system for general practitioners in home-based sleep disorder diagnosis. Sleep disorders cost the Australian health system an estimated $40 million per year. General practitioner's surgeries are not well equipped to deal with diagnosis and the majority of the referrals to specialists are unnecessary. This research will investigate and develop an intelligent decision support system to provide a cost effective solution to this problem. The developed software application will enable sleep study to be carried out at home, enabling general practitioners to conduct a preliminary diagnosis. Benefits include a reduction in the costs incurred in travel, time off work and at hospital sleep care centres for people in remote areas.Read moreRead less
Enhancing natural enemy mortality of chrysomelids in young eucalypt plantations through habitat manipulation. Eucalyptus plantations are the future of Australian forestry. In eucalypt plantations leaf-feeding beetles reduce tree growth by an average of 53%, substantially reducing profits. Sustainable management of these pests is best done by maximising the impact of native beneficial agents, eg wasps and spiders. This research will quantify the beneficial insects in plantations and increase ....Enhancing natural enemy mortality of chrysomelids in young eucalypt plantations through habitat manipulation. Eucalyptus plantations are the future of Australian forestry. In eucalypt plantations leaf-feeding beetles reduce tree growth by an average of 53%, substantially reducing profits. Sustainable management of these pests is best done by maximising the impact of native beneficial agents, eg wasps and spiders. This research will quantify the beneficial insects in plantations and increase their efficacy by manipulating the plantation environment so it provides more of the resources (food & shelter) these beneficials require. This approach is significant as it has not been previously attempted in forestry. Our management recommendations will make the plantation sector more profitable and sustainable.Read moreRead less
Systematic evaluation of whether in vitro methods can predict in vivo opioid analgesic efficacy, safety and tolerability. It is estimated that chronic pain affects one in five individuals in the general community in Australia and worldwide, with prevalence rates correlated directly with advancing age. Chronic pain not only adversely affects the quality of life of individuals but it also places a large economic burden on our healthcare system. Development and validation of an in vitro method to ....Systematic evaluation of whether in vitro methods can predict in vivo opioid analgesic efficacy, safety and tolerability. It is estimated that chronic pain affects one in five individuals in the general community in Australia and worldwide, with prevalence rates correlated directly with advancing age. Chronic pain not only adversely affects the quality of life of individuals but it also places a large economic burden on our healthcare system. Development and validation of an in vitro method to successfully identify novel morphine-like strong analgesics with a reduced propensity for producing respiratory depression or constipation, has the potential to not only improve pain management for individuals and to reduce the economic burden of chronic pain on the Australian healthcare system, but it is also likely to produce direct economic benefits to our nation. Read moreRead less
Prevention and treatment of chlamydiosis and cryptococcosis in koalas. This project aims to generate increased understanding of the aetiology and pathogenesis of the two most prevalent and debilitating infectious diseases of koalas to make improved decisions regarding therapeutic intervention, prevention and management. Chlamydiosis, caused by two chlamydial bacteria, affects koala fertility, urinary tract function and eyesight. Cryptococcosis, caused by the fungus Cryptococcus gattii, may resul ....Prevention and treatment of chlamydiosis and cryptococcosis in koalas. This project aims to generate increased understanding of the aetiology and pathogenesis of the two most prevalent and debilitating infectious diseases of koalas to make improved decisions regarding therapeutic intervention, prevention and management. Chlamydiosis, caused by two chlamydial bacteria, affects koala fertility, urinary tract function and eyesight. Cryptococcosis, caused by the fungus Cryptococcus gattii, may result in koala morbidity and death. Planned therapeutic trials, prevention strategies and the development of optimal husbandry strategies will provide knowledge that will lead to reduced koala morbidity through improved understanding of the interactions amongst infectious pathogens, the animal host and the environment.Read moreRead less
Translating pharmacokinetic and pharmacodynamic data to better design new drugs for the treatment of Trypanosoma cruzi infection. New drugs to treat T. cruzi infection are urgently needed, however their design has been hampered by an incomplete understanding of complex host-parasite interactions, inadequate in vitro and in vivo tools to rigorously define activity during drug discovery, and a poor appreciation of concentration/effect relationships. This project aims to develop new and much needed ....Translating pharmacokinetic and pharmacodynamic data to better design new drugs for the treatment of Trypanosoma cruzi infection. New drugs to treat T. cruzi infection are urgently needed, however their design has been hampered by an incomplete understanding of complex host-parasite interactions, inadequate in vitro and in vivo tools to rigorously define activity during drug discovery, and a poor appreciation of concentration/effect relationships. This project aims to develop new and much needed in vitro methods to better define the kinetic and dynamic activity of new drug candidates, and will provide a rational basis for translating this information into lengthy animal models of T. cruzi infection. The outcome aims to be rationally designed drug candidates that are available in a shorter period of time and are suitable for further development.Read moreRead less
New drugs against parasitic nematodes of livestock animals. New drugs against parasitic nematodes of livestock animals. This project aims to develop an innovative technology platform to deliver novel anti-infectives as biotechnological outcomes, using postgenomics, computing and chemistry. Advanced molecular, computer and chemistry technologies provide unprecedented opportunities to design radically new interventions against socioeconomically important infectious diseases affecting billions of a ....New drugs against parasitic nematodes of livestock animals. New drugs against parasitic nematodes of livestock animals. This project aims to develop an innovative technology platform to deliver novel anti-infectives as biotechnological outcomes, using postgenomics, computing and chemistry. Advanced molecular, computer and chemistry technologies provide unprecedented opportunities to design radically new interventions against socioeconomically important infectious diseases affecting billions of animals worldwide. Anticipated outcomes are the design of radically new chemotherapies to control parasitic diseases, the translation of fundamental research into biotechnological outcomes, international visibility of Australian science, and a solid skills- and knowledge-base in veterinary drug development.Read moreRead less
A pan-genome reverse vaccinology approach to disease prevention in farmed fish. Evolution of new pathogen strains causes major problems in vaccinated animals because these variants can reinfect and cause severe disease in previously protected animals. This project will use state-of-the-art genomics to find new targets that are essential to all strain variants, enabling development of broadly cross-protective vaccines for farmed animals.
Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management proto ....Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management protocols for tick-borne disease in Australia.Read moreRead less
Insect age: an ecological genomics approach to understanding host-parasite interactions. The importance of insect age (or the age structure of a population of insects) in understanding relationships between insects and their abiotic and biotic environment has been stressed in many theoretical studies but seldom directly tested. This is because few tools exist that can accurately measure the age of a wild-caught insect with any accuracy. In this proposal we plan to use a genomics approach to deve ....Insect age: an ecological genomics approach to understanding host-parasite interactions. The importance of insect age (or the age structure of a population of insects) in understanding relationships between insects and their abiotic and biotic environment has been stressed in many theoretical studies but seldom directly tested. This is because few tools exist that can accurately measure the age of a wild-caught insect with any accuracy. In this proposal we plan to use a genomics approach to develop tools that can be used to efficiently determine the age of an insect and then apply these tools to better understand the relationship between insect age and the ability of an insect to transmit pathogens to humans, livestock or plants. These tools will also have future applicability in developing new approaches to control insect transmitted disease as well as provide methodology to determine the effectiveness of current control programs that seek to kill pest insect populations of agricultural or public health significance.Read moreRead less
Emergence of a virulent strain of West Nile virus causing fatal equine encephalitis in south-eastern Australia. In 2011 a large outbreak of encephalitis in horses occurred in south-eastern Australia that was caused by a new virus that is transmitted by mosquitoes and is related to West Nile virus, known to cause severe disease in humans and horses. This project will study this new virus and develop improved methods for diagnosis and control of this disease.