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Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100022
Funder
Australian Research Council
Funding Amount
$4,787,259.00
Summary
ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop pr ....ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop protection. An expert multidisciplinary team uniting science, commercial and social licence pathways ensures industry and consumer uptake advancing $60B Australian Agriculture. The Hub translates to increased productivity, market access and enhanced environmental credentials of Australian food.
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Personalised Learning for Per-pixel Prediction Tasks in Image Analysis. AI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored ....Personalised Learning for Per-pixel Prediction Tasks in Image Analysis. AI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored to individual characteristics. The success of this project could significantly advance the fundamental research in image analysis. Expected outcomes include new knowledge and algorithms for image analysis, which could benefit fields like biology and archaeology, where labeled images are hard to attain and scarce.Read moreRead less
Combating myrtle rust, a new disease threatening Australia’s unique flora. This project aims to reduce the impact of myrtle rust, an invasive plant disease. Myrtle rust is a globally significant biodiversity threat that is rapidly spreading to new regions. It affects many iconic native species as well as impacting commercial industries. The expected project outcomes are; a comprehensive understanding of the host genes involved in successful plant defence, and of the pathogen genes involved in th ....Combating myrtle rust, a new disease threatening Australia’s unique flora. This project aims to reduce the impact of myrtle rust, an invasive plant disease. Myrtle rust is a globally significant biodiversity threat that is rapidly spreading to new regions. It affects many iconic native species as well as impacting commercial industries. The expected project outcomes are; a comprehensive understanding of the host genes involved in successful plant defence, and of the pathogen genes involved in the establishment of parasitism. The project will employ new approaches that enhance the application of biotechnology to Australian biosecurity. Key expected benefits are; gene-specific tools for plant breeders and conservation land managers, and improved preparedness for the threat posed by new rust strains.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100027
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Plant Biosecurity. The ARC Training Centre in Plant Biosecurity aims to deliver a solution for Australia’s increasing biosecurity risk through generational change in its workforce coupled with breakthrough technologies. It will launch an innovative training program for future leaders who will build relationships with end users and engage meaningfully with communities for effective implementation strategies. Expected outcomes include a cohort of highly skilled graduates tha ....ARC Training Centre in Plant Biosecurity. The ARC Training Centre in Plant Biosecurity aims to deliver a solution for Australia’s increasing biosecurity risk through generational change in its workforce coupled with breakthrough technologies. It will launch an innovative training program for future leaders who will build relationships with end users and engage meaningfully with communities for effective implementation strategies. Expected outcomes include a cohort of highly skilled graduates that will innovate novel diagnostic technologies, enable data-driven decision platforms and address barriers to biosecurity adoption. This suite of graduates and technologies will transform the plant biosecurity sector to protect Australia’s $5.7 trillion natural and productive ecosystems.Read moreRead less
Vulnerability of Australian bats to white-nose syndrome. Australia's unique wildlife is inherently at risk from invasive novel pathogens. White-nose syndrome is an emerging fungal disease that has decimated bat populations across North America. This fungal disease is likely to soon jump continents and also seriously threaten Australia's bat fauna. This project aims to quantify the risk of exposure to this fungus and understand the sensitivity of Australian bat populations to white-nose syndrome ....Vulnerability of Australian bats to white-nose syndrome. Australia's unique wildlife is inherently at risk from invasive novel pathogens. White-nose syndrome is an emerging fungal disease that has decimated bat populations across North America. This fungal disease is likely to soon jump continents and also seriously threaten Australia's bat fauna. This project aims to quantify the risk of exposure to this fungus and understand the sensitivity of Australian bat populations to white-nose syndrome mortality. Expected outcomes include spatially-explicit, species-specific models of vulnerability to white-nose syndrome for bat populations across south-eastern Australia, essential for directing actions to prevent, detect and mitigate the impacts of this potentially catastrophic wildlife disease.Read moreRead less
Understanding when biocontrol and enemy release affect plant populations. This project aims to determine when introduced species escape from their natural enemies, and when biocontrol efforts succeed. Enemy release and biocontrol are key to our understanding and management of invasions. However there has never been a broad quantitative assessment of the circumstances under which biocontrol and enemy release affect introduced populations. This project will use a combination of meta-analyses and i ....Understanding when biocontrol and enemy release affect plant populations. This project aims to determine when introduced species escape from their natural enemies, and when biocontrol efforts succeed. Enemy release and biocontrol are key to our understanding and management of invasions. However there has never been a broad quantitative assessment of the circumstances under which biocontrol and enemy release affect introduced populations. This project will use a combination of meta-analyses and international field studies to address this knowledge gap. Expected outcomes include a better understanding of the factors that facilitate biological invasions, and improved success of biocontrol agents.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC150100026
Funder
Australian Research Council
Funding Amount
$3,732,019.00
Summary
ARC Training Centre for Fruit Fly Biosecurity Innovation. ARC Training Centre for Fruit Fly Biosecurity Innovation. This training centre aims to transform the way that horticulture industries combat invasive fruit flies that threaten Australian crops, which are valued at $9 billion per year. For generations, Australia has relied on insecticides to protect crops. Owing to environmental damage and concerns for consumer health, the most effective insecticides have recently been banned for use on ma ....ARC Training Centre for Fruit Fly Biosecurity Innovation. ARC Training Centre for Fruit Fly Biosecurity Innovation. This training centre aims to transform the way that horticulture industries combat invasive fruit flies that threaten Australian crops, which are valued at $9 billion per year. For generations, Australia has relied on insecticides to protect crops. Owing to environmental damage and concerns for consumer health, the most effective insecticides have recently been banned for use on many crops leaving no equivalent replacements. Horticulture industries are unprepared for this change, and are in desperate need of new sustainable practices to combat fruit flies. New researchers who are trained in both scientific approach and practical application will be well placed to deliver these new tools.Read moreRead less
ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the d ....ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the design of peptides and proteins for targeted scientific, agricultural, biotechnology, animal health and pharmaceutical applications. CIPPS will assemble leading researchers from diverse disciplines to create a sustainable national entity that will drive new Australian industries and train next generation researchers.Read moreRead less
“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EA ....“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EAGLE-XL. MAGPI will deliver exquisite kinematics for hundreds of galaxies in the middle ages of the Universe, providing a view to the effect of dark matter on galaxies at this critical time, while EAGLE-XL represents the technological frontier in simulations and provides the best interpretative framework for MAGPI.Read moreRead less