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Age and Gender Related Changes in Motor Control of the Upper Airway Muscle Genioglossus During Sleep. Obstructive Sleep Apnoea (OSA) is the repetitive obstruction of the airway during sleep. Obstructions occur because muscles of the upper airway fail to keep the airway open during inspiration. The disorder is associated with cardiovascular disease and cognitive and behavioural impairment. The prevalence of the disorder increases in older adults, contributing to age-related health and behavioural ....Age and Gender Related Changes in Motor Control of the Upper Airway Muscle Genioglossus During Sleep. Obstructive Sleep Apnoea (OSA) is the repetitive obstruction of the airway during sleep. Obstructions occur because muscles of the upper airway fail to keep the airway open during inspiration. The disorder is associated with cardiovascular disease and cognitive and behavioural impairment. The prevalence of the disorder increases in older adults, contributing to age-related health and behavioural problems. However, age-related changes differ in men and women. We believe the high prevalence of OSA in older adults is due to age and gender related changes in the activity of muscles in the upper airway. We will study the behaviour of the upper airway muscle genioglossus during sleep in young, middle-aged and older men and women.Read moreRead less
The use of social marketing strategies and adult education principles to improve asthma self management in older people. Asthma is estimated to affect up to 10 per cent of people aged 65+ some of whom experience the condition for the first time later in life. Mortality rates from asthma in Australia are highest in the older population and statistics show that older people are most likely to be admitted to hospital following attendance at an Emergency Department for asthma. Older people lack aw ....The use of social marketing strategies and adult education principles to improve asthma self management in older people. Asthma is estimated to affect up to 10 per cent of people aged 65+ some of whom experience the condition for the first time later in life. Mortality rates from asthma in Australia are highest in the older population and statistics show that older people are most likely to be admitted to hospital following attendance at an Emergency Department for asthma. Older people lack awareness about asthma, often manage it poorly, and their health related quality of life is impacted by asthma. There is disparity in asthma information, management and service provision targeted specifically to the needs of the elderly. This project will provide much-needed evidence on the effectiveness of carefully researched and targeted programs for older asthmatics.Read moreRead less
Novel human tryptases: their potential role in inflammatory diseases of the young and old. We have discovered a number of novel human tryptases, and while other members of this enzyme family have been implicated in the development of inflammatory diseases (including rheumatoid arthritis), little is known about these new molecules. We aim to characterise these new enzymes by determining what part of the body they are produced in, whether they are associated with specific inflammatory diseases, an ....Novel human tryptases: their potential role in inflammatory diseases of the young and old. We have discovered a number of novel human tryptases, and while other members of this enzyme family have been implicated in the development of inflammatory diseases (including rheumatoid arthritis), little is known about these new molecules. We aim to characterise these new enzymes by determining what part of the body they are produced in, whether they are associated with specific inflammatory diseases, and what target molecules they act on. A better understanding of these factors will increase the chances of finding cures and developing better treatments for important inflammatory diseases of the ageing population.Read moreRead less