A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Longitudinal Characterization Of Respiratory And Immune Development From Birth To Adulthood In The Perth Respiratory Birth Cohort
Funder
National Health and Medical Research Council
Funding Amount
$528,885.00
Summary
The Perth Respiratory Birth Cohort Study began in 1987 and has assessed 253 children before birth and at follow-up at 1, 6 & 12 months, and 6, 11 & 18 years of age. The study has resulted in 63 publications and achieved consistent international prominence. The proposed study of the cohort at 24 yrs aims to determine the respiratory and immunological status of the cohort as young adults. This follow-up is essential to determine how early risk factors affect respiratory outcome in young adults.
Low Dose Computed Tomography (LDCT) To Diagnose Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$3,032,884.00
Summary
This study aims to examine strategies for improving the effectiveness of lung cancer screening for reducing lung cancer deaths, and reducing the burden of the disease in the community. We will test the use of CT screening combined with a package of diagnostic measures, including the US NLST criteria, to determine if lung cancer nodules can be reliably detected at an earlier stage. Our aim in early detection is to also improve the potential for effective treatment approaches and health outcomes.
Developing Lung Function Reference Ranges In Aboriginal Australians
Funder
National Health and Medical Research Council
Funding Amount
$875,382.00
Summary
Lung function in Aboriginal Australians may be up to 30% lower than that of the Caucasian population. Comparing a patient’s lung function result to normal is critical to help diagnose and manage lung diseases. There are no lung function normal ranges for Aboriginal Australians. Our study will measure lung function in healthy Aboriginal children and adults and develop Aboriginal specific reference values and thus help ensure the highest level of clinical care for Aboriginal patients.
Towards Reducing The Susceptibility Of “high Risk” Infants To Allergic Asthma By Therapeutic Modulation Of Immunoregulatory Functions In The Pregnant Mother.
Funder
National Health and Medical Research Council
Funding Amount
$445,681.00
Summary
This project will deliver information in relation to the potential use and underlying modes of action of a therapeutic agent fed to pregnant mothers at high risk for atopic children, to protect against allergic asthma development in their offspring. Furthermore, the project will address the benefits of this therapeutic agent in relation to protection against inflammation induced preterm birth.
Evaluation Of The Effectiveness Of The 13-valent Pneumococcal Conjugate Vaccine On Pneumococcal Serotypes Causing Pneumonia In Children
Funder
National Health and Medical Research Council
Funding Amount
$1,137,532.00
Summary
Streptococcus pneumonia (Pneumococcus) is a bug that is a leading cause of childhood morbidity and mortality world-wide. Vaccinations have been recently brought onto the national immunisation program to try and combat this. This study aims to assess the new 13 valent Pneumococcal vaccine by studying its effectiveness in preventing childhood pneumonia in Australia by analysing the strains of Pneumococus in the blood and the fluid surrounding the lining the lung in complicated pneumonia using sens ....Streptococcus pneumonia (Pneumococcus) is a bug that is a leading cause of childhood morbidity and mortality world-wide. Vaccinations have been recently brought onto the national immunisation program to try and combat this. This study aims to assess the new 13 valent Pneumococcal vaccine by studying its effectiveness in preventing childhood pneumonia in Australia by analysing the strains of Pneumococus in the blood and the fluid surrounding the lining the lung in complicated pneumonia using sensitive molecular techniques.Read moreRead less
Vitamin D Supplementation To Prevent Respiratory Infections Among Indigenous Children In The Northern Territory: A Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$3,164,379.00
Summary
Acute respiratory infections remain unacceptably common among Indigenous children in the Northern Territory. Most Indigenous infants are born with suboptimal vitamin D levels and this is associated with an increased risk of ARI. We propose to conduct a clinical trial to determine whether daily vitamin D supplementation, during the third trimester of pregnancy and early infancy, can reduce the risk of infant ARI during the first 12 months of life.
Prevalence, Phenotype And Genotype Of Common Sleep Disorders
Funder
National Health and Medical Research Council
Funding Amount
$1,465,164.00
Summary
There is a critical need for more information on the prevalence and genetic basis of sleep disorders. The proposed study will leverage off data already collected from participants of the WA (Raine) pregnancy cohort, an internationally unique longitudinal study of 2,868 individuals followed over the last 23 yrs with comprehensive assessments starting in utero, continuing through childhood and into early adulthood.The study will replicate this battery of tests in the parents of these young adults.
Nasal Highflow For Paediatric Acute Hypoxic Respiratory Failure
Funder
National Health and Medical Research Council
Funding Amount
$2,627,819.00
Summary
The burden of respiratory disease in children requiring intensive care admission is increasing despite better quality care in hospitals. This study investigates a new method, called nasal high flow, to support the breathing of children, that can be provided in regular children's wards in regional and metropolitan hospitals. The study anticipates to demonstrate that early intervention with nasal high flow reduces the need for intensive care admission.
Novel Inhalation Formulation Of Colistin And Combination Therapy Against Gram-negative 'superbugs'
Funder
National Health and Medical Research Council
Funding Amount
$513,896.00
Summary
Respiratory infections caused by multidrug-resistant Gram-negative bacteria are major health problems for Australians. Colistin is the last-resort defense in most cases. However, parenteral administration of colistin will cause serious side effects. This proposal applies an interdisciplinary approach using aerosol particle engineering, functional lung imaging and antimicrobial pharmacology to develop and characterise novel inhaled powder formulations of colistin and its rational combinations.