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Genetic And Environmental Factors And Early Lung Problems Can Be Related To Allergy And Poor Lung Development In Preschool Age Children
Funder
National Health and Medical Research Council
Funding Amount
$122,032.00
Summary
This important new collaboration between the Murdoch ChildrenÍs Research Institute and Barwon Health explores the impact of early lung development on longer term respiratory health. It utilises a newly validated, accurate and safe technique to measure lung function in young babies and children. Data on environmental factors and lung function will help us explore the risk factors for the development of allergy, asthma and lung infections in early life.
THE EFFECT OF LONG ACTING BRONCHODILATORS ON VENTILATION IN COPD
Funder
National Health and Medical Research Council
Funding Amount
$143,676.00
Summary
COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading ....COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading to more targeted therapeuticsRead moreRead less
First-in-human Evaluation Of A Novel Immunobiotic To Prevent Respiratory Infection
Funder
National Health and Medical Research Council
Funding Amount
$1,180,080.00
Summary
Respiratory infections are a leading cause of death and illness throughout the world. We have discovered a 'friendly' bacteria that can be applied up the nose to prevent ear infections and the 'flu in mice. We will now test this novel therapy in humans to check it is safe and that it stimulates the human immune system in the same way that it does in mice. This will provide essential information to conduct clinical trials, with the aim to produce a medicine that prevents respiratory infections.
Improving Pleural Procedures: Image Analysis And Training.
Funder
National Health and Medical Research Council
Funding Amount
$94,468.00
Summary
Currently, there is little evidence to guide the treatment of pleural disease, with common mismanagement and frequent adverse events. This project will develop image analysis tools, a clinical pathway and training to assist and guide clinicians in managing pleural disease, improving the diagnostic yield of pleural procedures, while reducing complication rates. It will offer a novel contribution to this young but blossoming field of respiratory medicine, ultimately leading to improved care for pe ....Currently, there is little evidence to guide the treatment of pleural disease, with common mismanagement and frequent adverse events. This project will develop image analysis tools, a clinical pathway and training to assist and guide clinicians in managing pleural disease, improving the diagnostic yield of pleural procedures, while reducing complication rates. It will offer a novel contribution to this young but blossoming field of respiratory medicine, ultimately leading to improved care for people with pleural disease.Read moreRead less
Regulation Of Pulmonary Responsiveness By Chronic Mechanical Strain And Its Role In Obstructive Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
The pressures required to breathe place a continuous but varying mechanical strain on airway passages and lung tissue. This mechanical strain may protect the airway from collapsing, however, this protection is deficient in lung diseases such as asthma. This project considers the possibility that abnormal mechanical strain occurring in lung disease predisposes the individual to debilitating and potentially life-threatening airflow obstruction.
Improving Lung Health Of Indigenous Children, Through Identifying Interventional Targets From Long Term Follow-up Studies And Preventive Strategies
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Long term consequences of respiratory disease among Indigenous children are a public health issue. Studies included in this research program will provide new data and broaden our understanding on clinical predictors that significantly impact on lung health in Indigenous children. The studies will also direct future interventions and management pathways. This research will also contribute to improved asthma management, prevent uptake of smoking contributing to an overall improvement in health.
Regulation Of Subcellular Localisation Of Respiratory Syncytial Virus M Protein: Implications For Pathology
Funder
National Health and Medical Research Council
Funding Amount
$580,195.00
Summary
Respiratory syncytial virus (RSV) is the major cause of viral pneumonia in infants and the elderly, causing more deaths in winter than influenza. We have observed RSV M protein in the nucleus of infected host cells where it inhibits host cell transcription. We propose to investigate the regulation of nuclear localisation of M by phosphorylation and binding to cellular factors and its importance to RSV pathogenesis. The results will relate strongly to future drug and vaccine development.
Neural Control Of Human Respiratory Muscles In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$450,132.00
Summary
This research examines how human inspiratory muscles that ‘pump’ air into the lungs are controlled in health and disease. We will study the interaction between automatic and voluntary control of breathing, about which very little is known. The control of breathing in patients who breathe against an inspiratory load (eg. asthma) and mechanically ventilated patients will be a focus of this research. Outcomes include better understanding of the control of breathing and improved patient care.
Increasing the utility of tetanus toxins by protein engineering. There are a variety of common diseases that are the result of muscular defects. Some of these may be able to be treated with an agent that increases muscle tone, thereby giving benefit to the patient in the alleviation of symptoms. This project aims to use some of the most potent substances known, bacterial toxins, and engineer them to be valuable agents for treatment of certain muscular disorders.