Randomised Double-blind Controlled Trial Of Oxygen Versus Air To Palliate Intractable End-of-life Dyspnoea When Pa02 >55
Funder
National Health and Medical Research Council
Funding Amount
$463,318.00
Summary
Shortness of breath at the end-of-life is one of the most feared symptoms. Unlike most other symptoms, it worsens as death approaches. Despite the fact that more than 50,000 Australian will die an expected death in the next year, of whom the majority will have breathlessness toward the end-of-life, we know little about how best to treat this symptom. Oxygen is frequently introduced but we have not identified whether it is more effective than medical air, and, if it is more effective, which patie ....Shortness of breath at the end-of-life is one of the most feared symptoms. Unlike most other symptoms, it worsens as death approaches. Despite the fact that more than 50,000 Australian will die an expected death in the next year, of whom the majority will have breathlessness toward the end-of-life, we know little about how best to treat this symptom. Oxygen is frequently introduced but we have not identified whether it is more effective than medical air, and, if it is more effective, which patients would most benefit from it. Because of this lack of evidence, oxygen is only funded in Australia in community settings for people who have severely low oxygen levels in their blood. Palliative oxygen is provided on a compassionate basis at times but this is on an ad hoc basis and does not ensure equitable access for people at the end of life who experience shortness of breath. This multi-centre study will compare oxygen and air, with neither the participant nor caring clinicians knowing which treatment they will receive. After careful explanation, volunteers who agree to participate will be asked to use the oxygen machine for at least 15 hours each day for 7 days and fill out a diary twice each day. Five centres across Australia are planning to enroll 240 participants in this study. Outcomes will include whether the sensation of breathlessness has improved, the overall quality of life while being treated, the ability to perform activities of daily living and any side effects experienced. This study is eagerly awaited by clinicians and health planners not only in Australia but in North America and Europe. This study will provide data in a long-standing international debate about the role of oxygen in people with relatively normal levels of oxygen in their blood who suffer from shortness of breath at the end-of-life.Read moreRead less
Adapting for an uncertain future: farmer behaviour in water-stressed basins. Given the future risk of water scarcity, farmers will need to plan for greater farm-level adaptation. Drought and policy reform have inflicted significant economic, social and personal stress upon Murray-Darling Basin rural communities. This project aims to aid water managers and policy makers with a greater understanding of transformational farmer adaptation in order to plan for the economic, social and health impacts ....Adapting for an uncertain future: farmer behaviour in water-stressed basins. Given the future risk of water scarcity, farmers will need to plan for greater farm-level adaptation. Drought and policy reform have inflicted significant economic, social and personal stress upon Murray-Darling Basin rural communities. This project aims to aid water managers and policy makers with a greater understanding of transformational farmer adaptation in order to plan for the economic, social and health impacts of future water scarcity from climate change and water reform-related policies. The focus will be on the Murray-Darling Basin, as well as undertaking a comparative analysis with water stressed basins in the United States.Read moreRead less
Improving water market outcomes through a better understanding of market behaviour. The issue of water resources and their sustainable use is probably the most important issue facing the rural sector. The water reform process and its aim to secure water for the environment will cause economic and social pain and result in structural change within the irrigation sector. Properly functioning water markets will play an instrumental role in facilitating this process by providing water for the envir ....Improving water market outcomes through a better understanding of market behaviour. The issue of water resources and their sustainable use is probably the most important issue facing the rural sector. The water reform process and its aim to secure water for the environment will cause economic and social pain and result in structural change within the irrigation sector. Properly functioning water markets will play an instrumental role in facilitating this process by providing water for the environment and allowing water to move between competing resources. This study will enable policy makers and water managers to optimise the positive outcome of water markets and increase the likely success of programs to purchase environmental water.Read moreRead less
Groundwater flow age distributions: Understanding open pit mine hydrology. This project aims to improve the estimation of the age of groundwater. Understanding groundwater age is critical for sustainable management and environmental tracers are increasingly used for this purpose. However, groundwater samples are inevitably mixtures of water of different ages. Since for most tracers the relationship between tracer concentration and age is not linear, different tracers can produce different mean a ....Groundwater flow age distributions: Understanding open pit mine hydrology. This project aims to improve the estimation of the age of groundwater. Understanding groundwater age is critical for sustainable management and environmental tracers are increasingly used for this purpose. However, groundwater samples are inevitably mixtures of water of different ages. Since for most tracers the relationship between tracer concentration and age is not linear, different tracers can produce different mean ages for the sample. This project aims to determine whether it is possible to determine moments of the groundwater age distributions from measurements made with different environmental tracers. The project also aims to examine whether the degree of heterogeneity within the aquifer can be determined from the disparity between ages obtained with different tracers. This project aims to tackle the largest problem with using groundwater chemistry to estimate water age – that mixing processes in the subsurface are never known. Solving this problem will allow much more accurate estimates of groundwater velocity and aquifer recharge rates. The groundwater industry contributes an estimated $6.8 billion per annum to the Australian economy, and this project will contribute to the sustainable management of the groundwater resource.Read moreRead less
East Australian climate extremes through the Holocene. The project aims to document climate variability in eastern Australia over the Holocene, the last 11,500 years. It seeks to develop Australia’s two highest-resolution Holocene climate records using novel techniques to infer past rainfall, temperature and evaporation. The project will combine the expertise of international drought and climate specialists with novel techniques developed by the Australian investigators to derive an unparalleled ....East Australian climate extremes through the Holocene. The project aims to document climate variability in eastern Australia over the Holocene, the last 11,500 years. It seeks to develop Australia’s two highest-resolution Holocene climate records using novel techniques to infer past rainfall, temperature and evaporation. The project will combine the expertise of international drought and climate specialists with novel techniques developed by the Australian investigators to derive an unparalleled record of drought duration, frequency and intensity. In particular, the project aims to determine the frequency, duration and causes of mega-droughts in eastern Australia, of which little is known. Expected project outcomes include improved decision making capacity for natural resource management, and planning.Read moreRead less
Innovation in agricultural sector Green House Gas abatement in NSW. This project aims to develop a land sector greenhouse gas abatement, food production and environmental economics model for NSW. We expect to identify innovation in carbon payment policy and brokerage business models to achieve agricultural GHG abatement, while simultaneously improving sustainability. Expected outcomes include evaluation of the innovations of expert landholders, related businesses and governments to find ways to ....Innovation in agricultural sector Green House Gas abatement in NSW. This project aims to develop a land sector greenhouse gas abatement, food production and environmental economics model for NSW. We expect to identify innovation in carbon payment policy and brokerage business models to achieve agricultural GHG abatement, while simultaneously improving sustainability. Expected outcomes include evaluation of the innovations of expert landholders, related businesses and governments to find ways to influence land use decisions. This should provide significant benefits to landholders, governments involved in land management and the public through increased productivity, profitability, biodiversity and ecosystem health in the context of future climate, agricultural commodity and carbon market uncertainties.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100328
Funder
Australian Research Council
Funding Amount
$374,000.00
Summary
Minimising transaction costs in Murray-Darling Basin water reform. Transaction costs provide social, economic, environmental and political barriers to the effectiveness of water reallocation policy in Australia. These costs are often difficult to quantify, but potentially are subject to measurement. This project aims to develop a comprehensive transaction cost framework for the Murray-Darling Basin that can be used to capture and measure transaction costs related to water policy. Further, the sc ....Minimising transaction costs in Murray-Darling Basin water reform. Transaction costs provide social, economic, environmental and political barriers to the effectiveness of water reallocation policy in Australia. These costs are often difficult to quantify, but potentially are subject to measurement. This project aims to develop a comprehensive transaction cost framework for the Murray-Darling Basin that can be used to capture and measure transaction costs related to water policy. Further, the scope of the cost measurement will involve a variety of data collection approaches. Outcomes include better water policy and management from arrangements that will span the divide between the Basin Plan and its implementation.Read moreRead less
Accelerating Consolidation and Closure of Mine Tailings Storage Facilities. All mining operations involve the production of waste. Many regard such waste (tailings) and their environmentally acceptable storage as constituting the largest waste problem on Earth because of the enormous damage and loss-of-life that have resulted from failures of tailings storage facilities. This project focuses on a dewatering technology, electro-osmosis (EO), which has yet to be fully operationalised, for improvin ....Accelerating Consolidation and Closure of Mine Tailings Storage Facilities. All mining operations involve the production of waste. Many regard such waste (tailings) and their environmentally acceptable storage as constituting the largest waste problem on Earth because of the enormous damage and loss-of-life that have resulted from failures of tailings storage facilities. This project focuses on a dewatering technology, electro-osmosis (EO), which has yet to be fully operationalised, for improving the strength, stability and settlement characteristics of the tailings. Sophisticated testing will be undertaken at three scales (lab, meso and, most importantly, field), as well as the development of generic numerical models, to create practical guidelines to facilitate the implementation of EO in mines around the world.Read moreRead less
Transitioning to a water-secure future in the Basin. Increased water scarcity threatens the viability of the Murray-Darling Basin. There has been little analysis conducted of the consequences of water market impediments. The economic dimensions of trade impediments, water management, water market intervention and the net social benefits of water markets are at the core of this project. In particular, this project aims to explore: the impact of impediments and policy in water markets; how further ....Transitioning to a water-secure future in the Basin. Increased water scarcity threatens the viability of the Murray-Darling Basin. There has been little analysis conducted of the consequences of water market impediments. The economic dimensions of trade impediments, water management, water market intervention and the net social benefits of water markets are at the core of this project. In particular, this project aims to explore: the impact of impediments and policy in water markets; how further water market products may increase water market efficiency; and, the nature and sources of transactions costs in markets. Benefits from this project will enhance resilience and adaptation of irrigators to future climate change and water shortages, as well as providing future policy guidance.Read moreRead less
Special Research Initiatives - Grant ID: SR0354677
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable terrestrial and riverine systems through integrated assessment and modelling. Australia must take the lead internationally in sustainability assessment and management; it hosts both the problems and expertise, and is proactive in integrating research and management. This Initiative unites, for the first time, leading researchers from all relevant disciplines to advance our knowledge for achieving sustainable terrestrial and riverine systems (STARS). The intended network can produce a ....Sustainable terrestrial and riverine systems through integrated assessment and modelling. Australia must take the lead internationally in sustainability assessment and management; it hosts both the problems and expertise, and is proactive in integrating research and management. This Initiative unites, for the first time, leading researchers from all relevant disciplines to advance our knowledge for achieving sustainable terrestrial and riverine systems (STARS). The intended network can produce assessments, strategies and policy directions that are objective, adaptive and inclusive. It can evaluate trade-offs between sustainability strategies, integrating research and outcomes, making them accessible to managers. It will build a coordinated research capability that directly supports Australia's goal of ecologically sustainable development. Read moreRead less