A Randomised Open-label Study Comparing The Safety And Efficacy Of Two Alternative Treatment Options In The Management Of HIV-1 Infected Participants Who Have Virologically Failed A Standard First-line Combination ART Regimen
Funder
National Health and Medical Research Council
Funding Amount
$457,676.00
Summary
For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.
Strenthening The Contribution Of Australian General Practice To The Control Of Pandemic Influenza
Funder
National Health and Medical Research Council
Funding Amount
$110,257.00
Summary
Most primary and preventive care in Australia occurs in general practice. Australian general practice will therefore have a critical role to play in control efforts during an influenza pandemic, and also in sustaining other primary health care activities. After an initial surge in attendances, there may be a decline in attendance, as Australians become more reluctant to congregate in a place where they may become ill. This study seeks to complement the Australian Pandemic Influenza Management Pl ....Most primary and preventive care in Australia occurs in general practice. Australian general practice will therefore have a critical role to play in control efforts during an influenza pandemic, and also in sustaining other primary health care activities. After an initial surge in attendances, there may be a decline in attendance, as Australians become more reluctant to congregate in a place where they may become ill. This study seeks to complement the Australian Pandemic Influenza Management Plan by developing a range of action plans for use by general practitioners and public health authorities to support essential primary health care functions through a pandemic, and maximize general practice's contribution to control efforts. A range of methods will be used, including systematic review of existing literature, economic modeling of the Medicare costs and savings of different models of health care, interviews with key informants who have helped develop disaster response plans for general practice, or who are in positions of leadership. The project will culminate in the development of a simulation exercise to be used as a self-assessment tool for general practitioners, and a summit of general practice stakeholders who will help to finalise agreed action plans for the general practice response to pandemic influenza.Read moreRead less
The renewal of my Practitioner Fellowship will continue to facilitate an expanding program of epidemiological and clinical research in viral hepatitis, with a primary focus on hepatitis C. New directions will include development of international clinical cohort and trials networks, particularly to characterise the natural history of early hepatitis C infection and evaluate hepatitis C therapuetic strategies for injecting drug users.
This Centre of Research Excellence will translate the best available evidence to improve cancer outcomes through better management of infections in cancer patients, a rapidly growing group. We will establish new research networks to detect emerging multi resistant infections, develop guidelines on how to manage them, implement locally successful programs that have been shown to save lives nationally and validate new practice changing immune, bioinformatics and diagnostic technologies.
Australian Partnership (for) Preparedness Research On InfectiouS (disease) Emergencies (APPRISE)
Funder
National Health and Medical Research Council
Funding Amount
$4,996,416.00
Summary
We have assembled national experts in clinical, laboratory and public health research to ensure Australia is equipped for a coordinated, effective and evidence based response to infectious diseases. This multidisciplinary team will create and share new knowledge to detect, prevent and manage emerging infection threats. We will train a robust cross-sectoral work force and develop sustainable research capacity integrated within the health system to ensure national and regional health security.
Improving Outcomes In Patients With Community-acquired Severe Sepsis: The Role Of Pre-hospital Antibiotics.
Funder
National Health and Medical Research Council
Funding Amount
$265,138.00
Summary
Severe sepsis occurs when infection causes organ dysfunction. If not treated early, outcomes remain poor. Foremost in effectively treating this condition is the initiation of broad-spectrum antibiotics. This Fellowship will assess the feasibility, efficacy, and safety of pre-hospital antibiotics administered by paramedics to patients with suspected community-acquired severe-sepsis, as a means to improve patient outcomes in this highly vulnerable group.
Optimising Patient Outcomes Following Surgery: Bridging The Fields Of Antimicrobial Stewardship, Microbiology And Infection Prevention
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Over 2.4 million surgeries are performed yearly in Australia. Up to 15% of procedures are complicated by infection leading to patient suffering. These infections are also implicated in the emergence of antibiotic resistance. My research will help us understand how infections develop, how to prevent these infections and how to incorporate best-practice into patient care. My research will bridge these key areas to help improve outcomes for patients undergoing surgical procedures.
The Primary HIV Combined United Database (PCUD) is the largest database of patients with primary HIV infection in Australia. Dating back to 1983, it collects data from people with HIV seroconversion. Primary HIV infection, or seroconversion provides a unique opportunity to study HIV throughout its natural history. This study aims to link data on long term health outcomes such as AIDS, cancer and cardiovascular disease in this cohort, which can then be used to understand the determinants of progr ....The Primary HIV Combined United Database (PCUD) is the largest database of patients with primary HIV infection in Australia. Dating back to 1983, it collects data from people with HIV seroconversion. Primary HIV infection, or seroconversion provides a unique opportunity to study HIV throughout its natural history. This study aims to link data on long term health outcomes such as AIDS, cancer and cardiovascular disease in this cohort, which can then be used to understand the determinants of progression and complications of HIV infection.Read moreRead less